Relying on the Acquired Immune Deficiency Syndrome (AIDS) prevention and control system of project areas and existing health information network, according to the requirements of prevention and treatment of AIDS, and the "National Norms of Basic Public Health Services" as well as the "Community Comprehensive Prevention and Control of Major Contagious Diseases Programs and Procedures" and other regulatory requirements, this project, based on the residents' health records, using B/Sstructure, SSHframe, MVCmodel, ORACLE 10.0 database, is to develop residents' health records information management platform for the comprehensive prevention and control of AIDS, and make the existing AIDS epidemic system, the hospital information management system, residents' health records and health information system interconnected. It contributes to the participation of the administrative department of health, centers for disease control and prevention, hospital and community, and easily promotes organizations to provide technical support for the prevention and control system of AIDS. The platform has been successfully run in five project regions in Henan province, and has established 2, 365, 802 residents' health records about HIV/AIDS prevention and control, produced a good social and economic benefits. Its outlook is promising.