How Well Did You Locate Me? Effective Evaluation of Twitter User Geolocation

Translational medicine requires facile experimental systems to replicate the dynamic biological systems of diseases. Drug approval continues to lag, partly due to incongruencies in the research pipeline that traditionally involve 2D models, which could be improved with 3D models. The bone marrow (BM) poses challenges to harvest as an intact organ, making it difficult to study disease processes such as breast cancer (BC) survival in BM, and to effective evaluation of drug response in BM. Furthermore, it is a challenge to develop 3D BM structures due to its weak physical properties, and complex hierarchical structure and cellular landscape. To address this, we leveraged 3D bioprinting to create a BM structure with varied methylcellulose (M): alginate (A) ratios. We selected hydrogels containing 4% (w/v) M and 2% (w/v) A, which recapitulates rheological and ultrastructural features of the BM while maintaining stability in culture. This hydrogel sustained the culture of two key primary BM microenvironmental cells found at the perivascular region, mesenchymal stem cells and endothelial cells. More importantly, the scaffold showed evidence of cell autonomous dedifferentiation of BC cells to cancer stem cell properties. This scaffold could be the platform to create BM models for various diseases and also for drug screening.

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Cost-Effective Evaluation and Management of Cranial Neuropathy

Cost-Effective Evaluation and Management of Cranial Neuropathy ◽

10.1055/b-0040-174399 ◽

2020 ◽

Keyword(s):

Cost Effective ◽

Cranial Neuropathy ◽

Effective Evaluation

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A cost-effective evaluation of biomass district heating in rural communities

Applied Energy ◽

10.1016/j.apenergy.2015.10.106 ◽

2016 ◽

Vol 162 ◽

pp. 561-569 ◽

Cited By ~ 35

Author(s):

Aaron M. Hendricks ◽

John E. Wagner ◽

Timothy A. Volk ◽

David H. Newman ◽

Tristan R. Brown

Keyword(s):

Rural Communities ◽

District Heating ◽

Cost Effective ◽

Effective Evaluation

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Three Novel Time and Cost Effective Evaluation Coverage Drive Test of Mobile Networks by Regulatory

Wireless Personal Communications ◽

10.1007/s11277-014-1738-7 ◽

2014 ◽

Vol 78 (1) ◽

pp. 107-118

Author(s):

Jahangir Dadkhah Chimeh

Keyword(s):

Mobile Networks ◽

Cost Effective ◽

Effective Evaluation

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Experimental Investigations on Ultimate Behavior of Fabricated Mobile Scaffolds

Metals ◽

10.3390/met11060851 ◽

2021 ◽

Vol 11 (6) ◽

pp. 851

Author(s):

Heesoo Kim ◽

Jeonghyeon Lim ◽

Jeonghwa Lee ◽

Young Jong Kang ◽

Seungjun Kim

Keyword(s):

Evaluation Methods ◽

System Level ◽

Structural Safety ◽

Structural Performance ◽

Experimental Investigations ◽

Rigorous Evaluation ◽

Effective Evaluation ◽

Test Models ◽

Behavior Characteristics ◽

Structural Behaviors

A fabricated mobile scaffold has various components, including vertical members, horizontal members, braces, work plates, and castor wheels. In Korea, the structural performance of each member must be validated based on member-level structural safety criteria; this means that rigorous evaluation methods are required to secure the system-level structural safety of the fabricated mobile scaffold. To suggest rational system-level structural safety criteria and effective evaluation methods, the characteristics of the structural behaviors of the assembled structure must be investigated first. Unlike other temporary equipment, it is a product that requires convenience of use and ease of movement. Therefore, to secure the safety and usability of the structure, it is necessary to evaluate the ultimate behavior of a mobile scaffold fabricated with various material and structural types. In an experimental study, the ultimate mode and load-bearing capacity were investigated, and the appropriateness of the required performance of the mobile scaffold was reviewed. Three types of experimental test models with different materials (steel and aluminum) and stories (single-story and three-story erection) were selected and examined for vertical loads. Based on the experimental results, the ultimate behavior characteristics of the fabricated mobile scaffold were analyzed, and the ultimate load was identified.

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