Partial Volume Correction of Small Animal PET Cardiac Dynamic Images Using Iterative Reconstruction: Effects on Glucose Metabolic Rate Measurement

Abstract In dynamic cardiac PET FDG studies the assessment of myocardial metabolic rate of glucose (MMRG) requires the knowledge of the blood input function (IF). IF can be obtained by manual or automatic blood sampling and cross calibrated with PET. These procedures are cumbersome, invasive and generate uncertainties. The IF is contaminated by spillover of radioactivity from the adjacent myocardium and this could cause important error in the estimated MMRG. In this study, we show that the IF can be extracted from the images in a rat heart study with 18F-fluorodeoxyglucose (18F-FDG) by means of Independent Component Analysis (ICA) based on Bayesian theory and Markov Chain Monte Carlo (MCMC) sampling method (BICA). Images of the heart from rats were acquired with the Sherbrooke small animal PET scanner. A region of interest (ROI) was drawn around the rat image and decomposed into blood and tissue using BICA. The Statistical study showed that there is a significant difference (p < 0.05) between MMRG obtained with IF extracted by BICA with respect to IF extracted from measured images corrupted with spillover.

Download Full-text

Effect of surrounding materials on iterative reconstruction-based line-source response function, and annihilations outside the source assessed by a small animal PET scanner

Annals of Nuclear Medicine ◽

10.1007/s12149-014-0841-x ◽

2014 ◽

Vol 28 (6) ◽

pp. 512-522 ◽

Cited By ~ 1

Author(s):

Yoshiharu Miyazaki ◽

Masato Kobayashi ◽

Ryoko Komatsu ◽

Akiko Hayashi ◽

Shoko Yonezawa ◽

...

Keyword(s):

Response Function ◽

Iterative Reconstruction ◽

Line Source ◽

Small Animal ◽

Small Animal Pet ◽

Animal Pet

Download Full-text

18F, 11C and 68Ga in small animal PET imaging

Nuklearmedizin ◽

10.3413/nukmed-0578-13-04 ◽

2013 ◽

Vol 52 (06) ◽

pp. 250-261 ◽

Cited By ~ 4

Author(s):

J. Muellauer ◽

R. Willimayer ◽

A. L. Goertzen ◽

T. Wanek ◽

O. Langer ◽

...

Keyword(s):

Rat Brain ◽

Brain Region ◽

Small Animal ◽

Small Animal Pet ◽

Strong Increase ◽

Time Activity ◽

Partial Volume ◽

Animal Pet ◽

Brain Data

Summary Aim: The partial volume effect (PVE) significantly affects quantitative accuracy in PET. In this study we used a micro-hollow sphere phantom filled with 18F, 11C or 68Ga to evaluate different partial volume correction methods (PVC). Additionally, phantom data were applied on rat brain scans to evaluate PVC methods on in vivo datasets. Methods: The four spheres (7.81, 6.17, 5.02, 3.90 mm inner diameter) and the background region were filled to give sphere-to-background (sph/bg) activity ratios of 20 : 1, 10 : 1, 5 : 1 and 2 : 1. Two different acquisition and reconstruction protocols and three radionuclides were evaluated using a small animal PET scanner. From the obtained images the recovery coefficients (RC) and contrast recovery coefficients (CRC) for the different sph/bg ratios were calculated. Three methods for PVC were evaluated: a RC based, a CRC based and a volume of interest (VOI) based method. The most suitable PVC methods were applied to in vivo rat brain data. Results: RCs were shown to be dependent on the radionuclide used, with the highest values for 18F, followed by 11C and 68Ga. The calculated mean CRCs were generally lower than the corresponding mean RCs. Application of the different PVC methods to rat brain data led to a strong increase in time-activity curves for the smallest brain region (entorhinal cortex), whereas the lowest increase was obtained for the largest brain region (cerebellum). Conclusion: This study was able to show the importance and impact of PVE and the limitations of several PVC methods when performing quantitative measurements in small structures.

Download Full-text