Brazilian Journal of Radiation Sciences
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Published By Sociedade Brasileira De Protecao Radiologica - Sbpr

2319-0612, 2319-0612

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Ana Carolina Bortoletto Dantas ◽  
Antonio Teixeira e Silva

The present study proposes a method for the execution of uncertainty and sensitivity analysis on TRANSURANUS code, adapted for the use of stainless steel AISI-348 as the cladding material for a PWR reactor fuel rod, thus allowing to determine which input data are more relevant to the TRANSURANUS models, as well as a confidence interval for the results. The analysis was made through Monte Carlo sampling, where input values related to the geometry and composition of the fuel rod were taken from a normal distribution truncated around fabrication tolerance values. The generated samples were used as TRANSURANUS input data, and after numerous executions of the code, the results pertaining to the fuel center line temperature, fuel rod inner pressure and cladding strains were used to obtain a confidence interval and to make a variance based sensitivity analysis, showing that the models used in TRANSURANUS are additive in nature, and input interactions are not relevant to the code.


2021 ◽  
Vol 9 (3) ◽  
Author(s):  
João Vitor do Carmo Barbosa ◽  
Rodrigo Modesto Gadelha Gontijo ◽  
Guilherme Cavalcante de Albuquerque Souza ◽  
Bruno Melo Mendes ◽  
Juliana Batista da Silva ◽  
...  

The small animal positron emission tomography (PET) scanner from Molecular Imaging Laboratory (LIM/CDTN) is dedicated to pre-clinical studies on new 18F and 11C-based radiopharmaceuticals and to development of novel applications for well-known radiopharmaceuticals. Thus, quality control tests recommended by the publication NEMA NU 4-2008 are routinely carried out to ensure the proper performance of PET scanner. The aim of this work was to evaluate the influence of image reconstruction protocols on the image quality, accuracy of attenuation and scatter corrections parameters for 18F and 11C PET images. PET images of the image quality phantom filed with 18F-FDG or 11C-PK1122 were acquired and then reconstructed using different reconstruction protocols. The reconstruction variables evaluated were the algorithms (FBP, MLEM-3D, OSEM-3D), the resolution mode (high/standard) and the number of iterations (10 to 150). Uniformity, spill-over ratio (SOR) and recovery coefficients (RC) tests were performed for each reconstructed image according NEMA NU 4-2008. PMOD software was used for image analysis. FBP based protocol generated noisier images compared to iterative algorithms (MLEM-3D or OSEM-3D) based protocols. The increase in the number of iterations resulted in higher standard deviation of the analyzed parameters for all reconstructed images. MLEM-3D and OSEM-3D based protocols generates similar results when number of iterations and resolution mode were identical. SOR and RC mean values remained stable when the number of iterations ranged from 40 to 150. This study allowed the evaluation of different image reconstruction protocols on important parameters of 18F and 11C PET image quality. Additionally, standard image reconstruction protocols to be adopted in LIM/CDTN laboratorial routine for 18F and 11C images reconstruction in preclinical studies were defined.


2021 ◽  
Vol 9 (3) ◽  
Author(s):  
André De Souza Bezerra ◽  
Carlos Alberto Zeituni ◽  
Maria Elisa Chuery Martins Rostelato

Observation and identification of predictive factors for results and morbidity are essential in the ideal selection of patients who can use brachytherapy as a treatment modality for prostate cancer. Thus, the objective of this research is to analyze the population of patients with prostate cancer treated at the General Public Hospital of Palmas in 2015, in the state of Tocantins. The method used was quantitative, with the characteristics of a retrospective, transversal and descriptive analysis. Held in the largest state health unit, the General Public Hospital of Palmas that, despite its large dimensions, lives with the main problems of the Unified Health System, such as overcrowding and shortages. It was found that most of the patients seen corresponded to the age of 70 to 79 years, making 45%, followed by patients aged between 60 and 69 years, with 33%. Most of the individuals attended were from the state of Tocantins, but some lived in an adjacent city in the state of Pará. Data related to the Gleason score showed that there was a predominance of levels 6 and 7 indicating intermediate grade tumors, considering that the most of the observed population was older. It was concluded that the analyzed patients had a predominant staging of CaP II and III, thus most of the individuals, 23 of the 35 analyzed, were not able to undergo brachytherapy due to the high degree of disease staging.


2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Kátia Pedrosa Silva ◽  
Maria Do Socorro Nogueira
Keyword(s):  

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Thiago De Medeiros Silveira Silva ◽  
Ana Carolina Lodi Lobato ◽  
Anne Karoline F. Mendonça ◽  
Ary Machado de Azevedo ◽  
Caio Cezar Pontes ◽  
...  

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Marcelo Vilela da Silva ◽  
Domingos D'Oliveira Cardoso ◽  
Sergio De Oliveira Vellozo

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Lillian Lettiere Bezerra Lemos Marques ◽  
Gabriela Leal Aguiar ◽  
Itamar Antonio Sousa Silva ◽  
Livia Teresa Moreira Rios

The concept of permanent education is materialized in the possibility of exchanging knowledge after initial training. This theme is of great importance to society and needs to be explored to provide a reflection on the reality of health services. This study presents permanent education for radiology services in accordance with current legislation and the project implemented at the University Hospital of the Federal University of Maranhão. The aim is to build a knowledge of continuing education in the health field, identifying the practice of this project and also contributing to the enrichment and theoretical dissemination aimed at diagnostic imaging services that make use of technologies with ionizing and non-ionizing radiation. Thus, improving the assistance and safety to radiology professionals and their users, through a gradual and appropriate knowledge.


2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Thiago De Medeiros Silveira Silva ◽  
Aneuri Souza de Amorim ◽  
Mario Cesar Viegas Balthar ◽  
Avelino dos Santos ◽  
Rodrigo Carneiro Curzio ◽  
...  

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Luiza Mascarenhas Balieiro ◽  
Henrique Barcellos de Oliveira ◽  
Luiz Felipe Teixeira Silva ◽  
Maria Helena Bellini ◽  
Margareth Mie Nakamura Matsuda ◽  
...  

Approximately 75% of breast cancer cells express estrogen receptor positive, being the second leading cause of cancer death among women worldwide with an incidence of 25% per year. 16α-[18F]-fluoro-17β-estradiol, FES-18F, is a radiopharmaceutical that binds to estrogen receptors enabling the acquisition of molecular images for non-invasive diagnosis of primary and metastatic breast cancer using PET-CT. The objective of this work was to study the synthesis of FES-18F in the GE TRACERlab® MXFDG module, using the chemical kit and the ABX® disposable cassette, and to determine the process yield and the analytical parameters to be used in the routine production of this radiopharmaceutical. Automated synthesis occurs in 75 minutes and includes percolation of [18F-] fluoride into an anion exchange cartridge, cartridge elution, 3-step azeotropic drying, labeling using precursor 3-methoxymethyl-16β,17β-epiestriol-O-cyclic sulfone (MMSE) and a hydrolysis step. Product purification is done in the module using solid phase extraction (SPE) cartridges. The radiochemical yield was reproductive, regardless of fluor-18 activity at entry into the module, and the results of quality control tests suggest that the radiopharmaceutical meets the criteria established for other fluor-18-labelled radiopharmaceuticals that have monographs in official compendiums. In vivo biodistribution studies in healthy animals and with a tumor model developed with MCF-7 cells, demonstrated radiopharmaceutical uptake in excretory organs and specificity for breast tumor cells.


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