Dimension reduction is an important issue to understand microarray data. In this study, we proposed a efficient approach for dimensionality reduction of microarray data. Our method allows to apply the manifold learning algorithm to analyses dimensionality reduction of microarray data. The intra-/inter-category distances were used as the criteria to quantitatively evaluate the effects of data dimensionality reduction. Colon cancer and leukaemia gene expression datasets are selected for our investigation. When the neighborhood parameter was effectivly set, all the intrinsic dimension numbers of data sets were low. Therefore, manifold learning is used to study microarray data in the low-dimensional projection space. Our results indicate that Manifold learning method possesses better effects than the linear methods in analysis of microarray data, which is suitable for clinical diagnosis and other medical applications.
Scaled PCA: A New Approach to Dimension Reduction