A Novel Approach of Human Hunger Detection especially for physically challenged people

Automobile is a comprehensive invention which became a basic need for every human. But some modifications were necessary in automobile design in case of differently abled person. The existing vehicle comprises with usual hand twist acceleration, hand lever braking and handlebar steer control. Conventionally, three wheeled rear axles are used by physically challenged person. If the physically challenged person is about to park his/her vehicle then he/she should get down for moving the vehicle. Hence a reverse drive feature is proposed for vehicle which can help them to move in reverse direction when they are in seating position. In our proposed vehicle, the acceleration can be controlled either by right hand twist accelerator in handlebar or by foot pedal. The acceleration switch determines the working of accelerators. For left hand impairment, they can switch to foot pedal acceleration. Here the rear braking is applied by left hand brake lever or foot brake pedal (to apply rear brake if they are left hand impaired).

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Prevention of unauthorized door access using face recognition built with Haar Cascade Classifier and Histogram of Oriented Gradients

10.14293/s2199-1006.1.sor-.pppvl0j.v1 ◽

2020 ◽

Author(s):

Arun Kumar Nadikattu ◽

Kundhan P ◽

John Shahid Sk ◽

Sunita Panda ◽

Kamalanathan Chandran

Keyword(s):

Face Recognition ◽

Remote Monitoring ◽

Cascade Classifier ◽

Security Systems ◽

Web Based ◽

Traditional System ◽

Novel Approach ◽

Haar Cascade ◽

Door Lock ◽

Physically Challenged

With the emergence of Internet of Things (IoT) along with its development of advanced authentication, both security and remote monitoring have become imperative as well as essential, and the need for smarter security systems has only been growing. The traditional system needs an individual to use a key or an identiﬁcation (ID) card or a password to access the security doors. However, they have many limitations such as keys can be forged, recreation of ID cards and passwords can be stolen. To overcome, the existing system issues, a novel approach is proposed with the design and development of face authenticated web-based smart door lock control system using facial recognition and remotely monitoring the door. In this proposed system OpenCVs self-trained Haar Cascade Classifier along with Histogram of Gradient is used for face Recognition. Door will be unlocked when users face is recognised else will remain closed. In case an unauthorised person is found, the time of intrusion and the intruders image will be captured and sent to a separate server on discord, so that the user or the admin can view them at their convenience. The main usage of this system is to assist users for improvement of the door security of sensitive locations by using face recognition and is also designed by considering the physically challenged persons also.

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Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

Biochemical Journal ◽

10.1042/bcj20190591 ◽

2019 ◽

Vol 476 (24) ◽

pp. 3705-3719 ◽

Cited By ~ 2

Author(s):

Avani Vyas ◽

Umamaheswar Duvvuri ◽

Kirill Kiselyov

Keyword(s):

Oxidative Stress ◽

Head And Neck ◽

Transcriptional Activation ◽

Platinum Resistance ◽

Mrna Levels ◽

Strong Positive Correlation ◽

Platinum Compounds ◽

Copper Chelation ◽

Novel Approach ◽

Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

Language Speech and Hearing Services in Schools ◽

10.1044/2020_lshss-19-00050 ◽

2020 ◽

Vol 51 (3) ◽

pp. 544-560 ◽

Cited By ~ 3

Author(s):

Kimberly A. Murphy ◽

Emily A. Diehm

Keyword(s):

Written Language ◽

Morphological Knowledge ◽

English Orthography ◽

Word Level ◽

Novel Approach ◽

Language Pathology ◽

The One ◽

Critical Intervention ◽

Reading And Spelling ◽

Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

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