The initial investigation of electromagnetics radiation for the right hemisphere stroke patient

Lateropulsion (pusher syndrome) is an important barrier to standing and gait after stroke. Although several studies have attempted to elucidate the relationship between brain lesions and lateropulsion, the effects of specific brain lesions on the development of lateropulsion remain unclear. Thus, the present study investigated the effects of stroke lesion location and size on lateropulsion in right hemisphere stroke patients. The present retrospective cross-sectional observational study assessed 50 right hemisphere stroke patients. Lateropulsion was diagnosed and evaluated using the Scale for Contraversive Pushing (SCP). Voxel-based lesion symptom mapping (VLSM) analysis with 3T-MRI was used to identify the culprit lesion for SCP. We also performed VLSM controlling for lesion volume as a nuisance covariate, in a multivariate model that also controlled for other factors contributing to pusher behavior. VLSM, combined with statistical non-parametric mapping (SnPM), identified the specific region with SCP. Lesion size was associated with lateropulsion. The precentral gyrus, postcentral gyrus, inferior frontal gyrus, insula and subgyral parietal lobe of the right hemisphere seemed to be associated with the lateropulsion; however, after adjusting for lesion volume as a nuisance covariate, no lesion areas were associated with the SCP scores. The size of the right hemisphere lesion was the only factor most strongly associated with lateropulsion in patients with stroke. These results may be useful for planning rehabilitation strategies of restoring vertical posture and understanding the pathophysiology of lateropulsion in stroke patients.

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Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study

Stroke ◽

10.1161/strokeaha.121.035733 ◽

2021 ◽

Author(s):

Olga Boukrina ◽

Mateusz Kowalczyk ◽

Yury Koush ◽

Yekyung Kong ◽

A.M. Barrett

Keyword(s):

Right Hemisphere ◽

Functional Neuroimaging ◽

Brain Network ◽

Spatial Neglect ◽

Stroke Recovery ◽

Network Activity ◽

Brain Disorder ◽

Fmri Study ◽

The Right ◽

Right Hemisphere Stroke

Background and Purpose: Delirium, an acute reduction in cognitive functioning, hinders stroke recovery and contributes to cognitive decline. Right-hemisphere stroke is linked with higher delirium incidence, likely, due to the prevalence of spatial neglect (SN), a right-brain disorder of spatial processing. This study tested if symptoms of delirium and SN after right-hemisphere stroke are associated with abnormal function of the right-dominant neural networks specialized for maintaining attention, orientation, and arousal. Methods: Twenty-nine participants with right-hemisphere ischemic stroke undergoing acute rehabilitation completed delirium and SN assessments and functional neuroimaging scans. Whole-brain functional connectivity of 4 right-hemisphere seed regions in the cortical-subcortical arousal and attention networks was assessed for its relationship to validated SN and delirium severity measures. Results: Of 29 patients, 6 (21%) met the diagnostic criteria for delirium and 16 (55%) for SN. Decreased connectivity of the right basal forebrain to brain stem and basal ganglia predicted more severe SN. Increased connectivity of the arousal and attention network regions with the parietal, frontal, and temporal structures in the unaffected hemisphere was also found in more severe delirium and SN. Conclusions: Delirium and SN are associated with decreased arousal network activity and an imbalance of cortico-subcortical hemispheric connectivity. Better understanding of neural correlates of poststroke delirium and SN will lead to improved neuroscience-based treatment development for these disorders.

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Studies on semantic priming effects in right hemisphere stroke: A systematic review

Dementia & Neuropsychologia ◽

10.1590/s1980-57642013dn70200004 ◽

2013 ◽

Vol 7 (2) ◽

pp. 155-163

Author(s):

Juliana de Lima Müller ◽

Jerusa Fumagalli de Salles

Keyword(s):

Systematic Review ◽

Semantic Priming ◽

Cerebral Hemisphere ◽

Semantic Processing ◽

Right Hemisphere ◽

Priming Effects ◽

Right Cerebral Hemisphere ◽

The Right ◽

Right Hemisphere Stroke

ABSTRACT The role of the right cerebral hemisphere (RH) associated with semantic priming effects (SPEs) must be better understood, since the consequences of RH damage on SPE are not yet well established. Objective: The aim of this article was to investigate studies analyzing SPEs in patients affected by stroke in the RH through a systematic review, verifying whether there are deficits in SPEs, and whether performance varies depending on the type of semantic processing evaluated or stimulus in the task. Methods: A search was conducted on the LILACS, PUBMED and PSYCINFO databases. Results: Out of the initial 27 studies identified, 11 remained in the review. Difficulties in SPEs were shown in five studies. Performance does not seem to vary depending on the type of processing, but on the type of stimulus used. Conclusion: This ability should be evaluated in individuals that have suffered a stroke in the RH in order to provide treatments that will contribute to their recovery.

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FV15 Revisiting the concept of apraxia in the right hemisphere: Evidence from 139 acute right hemisphere stroke patients

Clinical Neurophysiology ◽

10.1016/j.clinph.2019.12.105 ◽

2020 ◽

Vol 131 (4) ◽

pp. e230-e231

Author(s):

A. Dreßing ◽

L.A. Beume ◽

M. Martin ◽

D.Kümmerer ◽

H. Urbach ◽

...

Keyword(s):

Right Hemisphere ◽

Stroke Patients ◽

The Right ◽

Right Hemisphere Stroke

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Motor Extinction in Distinct Reference Frames: A Double Dissociation

Behavioural Neurology ◽

10.1155/2013/181903 ◽

2013 ◽

Vol 26 (1-2) ◽

pp. 111-119 ◽

Cited By ~ 1

Author(s):

Jennifer Heidler-Gary ◽

Mikolaj Pawlak ◽

Edward H. Herskovits ◽

Melissa Newhart ◽

Cameron Davis ◽

...

Keyword(s):

White Matter ◽

Reference Frames ◽

Right Hemisphere ◽

Hand Movements ◽

Lesion Site ◽

Left Hand ◽

Double Dissociation ◽

Ischemic Tissue ◽

The Right ◽

Right Hemisphere Stroke

Objective:Test the hypothesis that right hemisphere stroke can cause extinction of left hand movements or movements of either hand held in left space, when both are used simultaneously, possibly depending on lesion site.Methods:93 non-hemiplegic patients with acute right hemisphere stroke were tested for motor extinction by pressing a counter rapidly for one minute with the right hand, left hand, or both simultaneously with their hands held at their sides, or crossed over midline.Results:We identified two distinct types of motor extinction in separate patients; 20 patients extinguished left hand movements held in left or right space (left canonical body extinction); the most significantly associated voxel cluster of ischemic tissue was in the right temporal white matter. Seven patients extinguished either hand held in left space (left space extinction), and the most significantly associated voxel cluster of ischemic tissue was in right parietal white matter.Conclusions:There was a double dissociation between left canonical body extinction and left space motor extinction. Left canonical body extinction seems to be associated with more dorsal (parietal) ischemia, and left canonical body extinction seems to be associated with more ventral (temporal) ischemia.

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Impaired Recognition of Emotional Faces after Stroke Involving Right Amygdala or Insula

Seminars in Speech and Language ◽

10.1055/s-0037-1608859 ◽

2018 ◽

Vol 39 (01) ◽

pp. 087-100 ◽

Cited By ~ 7

Author(s):

Brittany Godin ◽

Kumiko Oishi ◽

Kenichi Oishi ◽

Cameron Davis ◽

Yessenia Gomez ◽

...

Keyword(s):

Facial Expressions ◽

Right Hemisphere ◽

Anterior Insula ◽

Human Anatomy ◽

Lesion Volume ◽

Stroke Patients ◽

Emotional Faces ◽

The Right ◽

Right Hemisphere Stroke

AbstractDespite its basic and translational importance, the neural circuitry supporting the perception of emotional faces remains incompletely understood. Functional imaging studies and chronic lesion studies indicate distinct roles of the amygdala and insula in recognition of fear and disgust in facial expressions, whereas intracranial encephalography studies, which are not encumbered by variations in human anatomy, indicate a somewhat different role of these structures. In this article, we leveraged lesion-mapping techniques in individuals with acute right hemisphere stroke to investigate lesions associated with impaired recognition of prototypic emotional faces before significant neural reorganization can occur during recovery from stroke. Right hemisphere stroke patients were significantly less accurate than controls on a test of emotional facial recognition for both positive and negative emotions. Patients with right amygdala or anterior insula lesions had significantly lower scores than other right hemisphere stroke patients on recognition of angry and happy faces. Lesion volume within several regions, including the right amygdala and anterior insula, each independently contributed to the error rate in recognition of individual emotions. Results provide additional support for a necessary role of the right amygdala and anterior insula within a network of regions underlying recognition of facial expressions, particularly those that have biological importance or motivational relevance and have implications for clinical practice.

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Welcoming back my arm: Affective touch increases body ownership following right hemisphere stroke

10.1101/851055 ◽

2019 ◽

Cited By ~ 1

Author(s):

Paul M. Jenkinson ◽

Cristina Papadaki ◽

Sahba Besharati ◽

Valentina Moro ◽

Valeria Gobbetto ◽

...

Keyword(s):

Right Hemisphere ◽

Experimental Studies ◽

Body Part ◽

Body Ownership ◽

Body Parts ◽

Unique Role ◽

Affective Touch ◽

Lesion Symptom Mapping ◽

The Right ◽

Right Hemisphere Stroke

AbstractRight hemisphere stroke can impair the ability to recognise one’s contralesional body parts as belonging to one’s self. The study of this so-called ‘disturbed sense of limb ownership’ (DSO) can provide unique insights into the neurocognitive mechanisms of body ownership. Here, we address a hypothesis built upon experimental studies on body ownership in healthy volunteers. These studies have shown that affective (pleasant) touch, an interoceptive modality associated with unmyelinated, slow-conducting C tactile afferents, has a unique role in the sense of body ownership. Here we systematically investigated whether affective touch stimulation could increase body ownership in patients with DSO following right hemisphere stroke. An initial feasibility study in 16 adult, acute stroke patients enabled us to optimise and calibrate an affective touch protocol to be administered by the bedside. The main experiment, conducted with a different sample of 26 right hemisphere patients, assessed changes in limb ownership elicited following self-(patient) versus other-(experimenter) generated tactile stimulation, using a velocity known to optimally activate C-tactile fibres (i.e. 3cm/s), and a second velocity that is suboptimal for C-tactile activation (i.e. 18cm/s). We further examined the specificity and mechanism of observed changes in limb ownership in secondary analyses looking at (1) the influence of perceived intensity and pleasantness of touch, (2) touch laterality, and (3) level of DSO on ownership change, as well as (4) changes in unilateral neglect arising from touch. Findings indicated a significant increase in limb ownership following experimenter-administered, CT-optimal touch. Voxel-based Lesion-Symptom Mapping (VLSM) identified damage to the right insula and, more substantially, the right corpus callosum, associated with a failure to increase body ownership following experimenter-administered, affective touch. Our findings suggest that affective touch can increase the sense of body-part ownership following right hemisphere stroke, potentially due to its unique role in the multisensory integration processes that underlie the sense of body ownership.

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Welcoming back my arm: affective touch increases body ownership following right-hemisphere stroke

Brain Communications ◽

10.1093/braincomms/fcaa034 ◽

2020 ◽

Vol 2 (1) ◽

Cited By ~ 2

Author(s):

Paul M Jenkinson ◽

Cristina Papadaki ◽

Sahba Besharati ◽

Valentina Moro ◽

Valeria Gobbetto ◽

...

Keyword(s):

Right Hemisphere ◽

Experimental Studies ◽

Body Part ◽

Body Ownership ◽

Body Parts ◽

Unique Role ◽

Affective Touch ◽

Lesion Symptom Mapping ◽

The Right ◽

Right Hemisphere Stroke

Abstract Right-hemisphere stroke can impair the ability to recognize one’s contralesional body parts as belonging to one’s self. The study of this so-called ‘disturbed sense of limb ownership’ can provide unique insights into the neurocognitive mechanisms of body ownership. In this study, we address a hypothesis built upon experimental studies on body ownership in healthy volunteers. These studies have shown that affective (pleasant) touch, an interoceptive modality associated with unmyelinated, slow-conducting C-tactile afferents, has a unique role in the sense of body ownership. In this study, we systematically investigated whether affective touch stimulation could increase body ownership in patients with a disturbed sense of limb ownership following right-hemisphere stroke. An initial feasibility study in 16 adult patients with acute stroke enabled us to optimize and calibrate an affective touch protocol to be administered by the bedside. The main experiment, conducted with a different sample of 26 right hemisphere patients, assessed changes in limb ownership elicited following self- (patient) versus other- (experimenter) generated tactile stimulation, using a velocity known to optimally activate C-tactile fibres (i.e. 3 cm/s), and a second velocity that is suboptimal for C-tactile activation (i.e. 18 cm/s). We further examined the specificity and mechanism of observed changes in limb ownership in secondary analyses looking at (i) the influence of perceived intensity and pleasantness of touch, (ii) touch laterality and (iii) level of disturbed sense of limb ownership on ownership change and (iv) changes in unilateral neglect arising from touch. Findings indicated a significant increase in limb ownership following experimenter-administered, C-tactile-optimal touch. Voxel-based lesion-symptom mapping identified damage to the right insula and, more substantially, the right corpus callosum, associated with a failure to increase body ownership following experimenter-administered, affective touch. Our findings suggest that affective touch can increase the sense of body-part ownership following right-hemisphere stroke, potentially due to its unique role in the multisensory integration processes that underlie the sense of body ownership.

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