An Integrated Design Method of New Product and the Production Process Based on Taguchi Robust Design

In this paper, we present robust concept exploration using a goal-oriented, inverse decision-based design method to carry out the integrated design of material, product and associated manufacturing processes by managing the uncertainty involved. The uncertainty in complex material and product systems is derived from many sources and we classify robust design based on these sources — uncertainty in noise factors (Type I robust design); uncertainty in design variables or control factors (Type II robust design); uncertainty in function relationship between control/noise and response (Type III robust design); and propagation and potential amplification of uncertainty in a process chain (Type I to III robust designs across process chains). In this paper, we introduce a variation to the existing goal-oriented inverse decision-based design method to bring in robustness for multiple conflicting goals from the stand-point of Type I to III robust design across process chains. The variation embodies the introduction of specific robust design goals and constraints anchored in the mathematical constructs of error margin indices and design capability indices to determine “satisficing robust design” specifications for given performance requirement ranges using the goal-oriented, inverse design method. The design of a hot rolling process chain for the production of a rod is used as an example.

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Fabrication of NiO/SiO2 nanocomposites using sol–gel method and optimization of gelation time using Taguchi robust design method

Colloids and Surfaces A Physicochemical and Engineering Aspects ◽

10.1016/j.colsurfa.2008.11.045 ◽

2009 ◽

Vol 336 (1-3) ◽

pp. 69-74 ◽

Cited By ~ 14

Author(s):

A. Kamyabi-Gol ◽

S.M. Zebarjad ◽

S.A. Sajjadi

Keyword(s):

Robust Design ◽

Design Method ◽

Sol Gel ◽

Gelation Time ◽

Gel Method ◽

Sol Gel Method ◽

Sio2 Nanocomposites ◽

Robust Design Method ◽

Taguchi Robust Design

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Development of ethosomes with taguchi robust design-based studies for transdermal delivery of alfuzosin hydrochloride

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i11.12063 ◽

2012 ◽

Vol 1 (11) ◽

pp. 370-375 ◽

Cited By ~ 5

Author(s):

D Prasanthi ◽

P K Lakshmi

Keyword(s):

Robust Design ◽

Transdermal Delivery ◽

Design Method ◽

Entrapment Efficiency ◽

Pharmaceutical Journal ◽

Dependent Variables ◽

Alfuzosin Hydrochloride ◽

Robust Design Method ◽

Taguchi Robust Design ◽

Drug Solution

In the present investigation efficiency of ethosomes as novel lipid carriers for transdermal delivery of Alfuzosin Hydrochloride (AH) has been evaluated. Taguchi robust design method was used for optimization of ethosomal formulations. Phospholipid type, concentration of phospholipid and concentration of ethanol was selected as independent variables and their effect on the dependent variables (entrapment efficiency and flux) was studied. Ethosomal formulation (EA8) with soya phosphatidylcholine (3%) and ethanol 20% were optimized. Vesicles were spherical, unilamellar with smooth surface. The optimized formulation exhibited vesicle size (6.85 ± 1.35µm), zeta potential (-8.14 ± 0.62mv), entrapment efficiency (91.86 ± 3.25%), flux (27.42 ± 0.04µg/cm2/hr), lag time (0.26±0.20hr) and skin deposition (298.01 ± 15.4µg/g). Transdermal flux was enhanced by 6.92 times over drug solution. Vesicle skin interaction studies showed fatty change in the dermis. The formulations were stable at 4°C for 120 days. Results suggested ethosomes as efficient carriers for AH transdermal delivery.DOI: http://dx.doi.org/10.3329/icpj.v1i11.12063 International Current Pharmaceutical Journal 2012, 1(11): 370-375

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