A novel decentralized adaptive integral sliding mode control law is proposed for a class of nonlinear uncertain large-scale systems subject to quantization mismatch between quantizer sensitivity parameters. Firstly, by applying linear matrix inequality techniques, integral-type sliding surface functions are derived for ensuring the stability of the whole sliding mode dynamics and obtaining the prescribed boundedL2gain performance. Secondly, the decentralized adaptive sliding mode control law is developed to ensure the reachability of the sliding manifolds in the presence of quantization mismatch, interconnected model uncertainties, and external disturbances. Finally, an example is shown to verify the validity of theoretical results.