The preparation and full NMR (H1,C13 and P31)
characterisation of three R3PAu
(2mba)
complexes, Where R = Et, Ph and Cy, and 2mba is the anion derived from 2-mercaptobenzoic acid
is reported. An interesting solvent dependence in the 1H spectra is rationalised in terms of
competing intra- and inter-molecular hydrogen bonding. An X-ray analysis of the [Ph3PAu(2mba)]
species reveals a linear P—Au—S arrangement and association in the lattice via the familar carboxylic acid dimer motif. The in Vitro cytotoxicity against seven human tumout lines is also
described. The complexes display moderate to very high activity. Particularly noteworthy is their greater activity against the H226 cell line (non-small cell lung cancer) compared with that displayed
by a range of cytotoxic drugs.
A novel machine learning‐based analytical framework for automatic detection of
COVID
‐19 using chest
X‐ray
images
