Improved three-dimensional remote aggregations of magnetotactic bacteria for tumor targeting

2016 ◽  
Author(s):  
Dumitru Loghin ◽  
Charles Tremblay ◽  
Sylvain Martel
Keyword(s):  
Tumor Targeting ◽  
Three Dimensional ◽  
Magnetotactic Bacteria

Three-dimensional remote aggregation and steering of magnetotactic bacteria microrobots for drug delivery applications

2013 ◽  
Vol 33 (3) ◽  
pp. 359-374 ◽  
Author(s):  
Dominic de Lanauze ◽  
Ouajdi Felfoul ◽  
Jean-Philippe Turcot ◽  
Mahmood Mohammadi ◽  
Sylvain Martel
Keyword(s):  
Drug Delivery ◽  
Three Dimensional ◽  
Magnetotactic Bacteria ◽  
Drug Delivery Applications

scholarly journals Photoacoustic in vivo 3D imaging of tumor using a highly tumor-targeting probe under high-threshold conditions

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hisatsugu Yamada ◽  
Natsuki Matsumoto ◽  
Takanori Komaki ◽  
Hiroaki Konishi ◽  
Yu Kimura ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Tumor Targeting ◽  
3D Imaging ◽  
Near Infrared ◽  
Three Dimensional ◽  
Cyanine Dye ◽  
High Threshold ◽  
Threshold Conditions

Abstract Three-dimensional (3D) representation of a tumor with respect to its size, shape, location, and boundaries is still a challenge in photoacoustic (PA) imaging using artificial contrast agents as probes. We carried out PA imaging of tumors in mice using 800RS-PMPC, which was obtained by coupling of 800RS, a near-infrared cyanine dye, with PMPC, a highly selective tumor-targeting methacrylate polymer having phosphorylcholine side chains, as a probe. The conjugate 800RS-PMPC forms compact nanoparticles (dDLS = 14.3 nm), retains the biocompatibility of the parent polymer (PMPC) and exhibits unprecedented PA performance. When applied to mice bearing a 6 × 3 × 3 mm3 tumor buried 6 mm beneath the skin, the probe 800RS-PMPC selectively accumulates in the tumor and emits PA signals that are strong enough to be unambiguously distinguished from noise signals of endogenous blood/hemoglobin. The PA image thus obtained under high-threshold conditions allows 3D characterization of the tumor in terms of its size, shape, location, and boundaries.

Polyhedral Boron Compounds as Potential Linkers for Attachment of Radiohalogens to Targeting Proteins and Peptides. A Review

2002 ◽  
Vol 67 (7) ◽  
pp. 913-935 ◽  
Author(s):  
Vladimir Tolmachev ◽  
Stefan Sjöberg
Keyword(s):  
Tumor Targeting ◽  
Three Dimensional ◽  
Boron Compounds ◽  
Boron Clusters ◽  
Aromatic Systems ◽  
Proteins And Peptides

Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.

The orbit of Pluto over a long interval of time

1966 ◽  
Vol 25 ◽  
pp. 227-229 ◽  
Author(s):  
D. Brouwer
Keyword(s):  
Periodic Orbit ◽  
Numerical Integration ◽  
Restricted Problem ◽  
Three Dimensional ◽  
The Third ◽  
Circular Restricted Problem ◽  
Resonance Relation

The paper presents a summary of the results obtained by C. J. Cohen and E. C. Hubbard, who established by numerical integration that a resonance relation exists between the orbits of Neptune and Pluto. The problem may be explored further by approximating the motion of Pluto by that of a particle with negligible mass in the three-dimensional (circular) restricted problem. The mass of Pluto and the eccentricity of Neptune's orbit are ignored in this approximation. Significant features of the problem appear to be the presence of two critical arguments and the possibility that the orbit may be related to a periodic orbit of the third kind.

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