Multiple-sensor micro-system for pulmonary function diagnostics for COPD and asthma patients

BACKGROUND AND OBJECTIVE:The reported effects of asthma on gastroesophageal reflux (GER), effects of GER on asthma and the effects of antireflux therapy on asthma are conflicting. The purpose of this paper is to review the evidence for a relationship between the two conditions.DESIGN:A search of the MEDLINE 1966 to 1999 database, combining the terms GER and asthma, was used to identify studies of the effects of acid perfusion of the esophagus, the physiological equivalent of GER and the effects of both medical and surgical antireflux therapy on asthma. Bibliographies of the identified papers were also reviewed.MAIN RESULTS:The collected evidence suggests that GER causes asthma symptoms but has minimal effects on pulmonary function. Both medical and surgical antireflux therapy can improve asthma symptoms and asthma medication requirements without improving pulmonary function. The paradox of GER causing symptoms without affecting pulmonary function may be because of the retrosternal discomfort that accompanies GER increases minute ventilation and respiratory sensation.CONCLUSIONS:Despite an extensive body of literature, many questions remain about the relationship between GER and asthma. A review of the data suggests a strong association between the two conditions, and that GER worsens asthma symptoms without affecting pulmonary function. Asymptomatic GER does not worsen asthma. Antireflux therapy may have a role in asthma patients with symptomatic GER, possibly being most beneficial for those with reflux-associated respiratory symptoms. Unfortunately, many studies contain flaws such as a lack of controls and small sample sizes. Further properly designed controlled trials, including ones that measure the effects of GER and antireflux therapy on quality of life, are needed to understand better the role of GER in asthma.

Download Full-text

Erosive Esophagitis Worsens Reflux Signs and Symptoms in Asthma Patients Without Affecting Pulmonary Function Tests

Journal of Asthma ◽

10.3109/02770903.2010.519077 ◽

2010 ◽

Vol 47 (10) ◽

pp. 1101-1105 ◽

Cited By ~ 3

Author(s):

Gulfidan Aras ◽

Kursat Yelken ◽

Dilek Kanmaz ◽

Omer Develioglu ◽

Osman Mavis ◽

...

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Tests ◽

Erosive Esophagitis ◽

Signs And Symptoms ◽

Function Tests ◽

Asthma Patients

Download Full-text

Effect of Asian dust on pulmonary function in adult asthma patients in western Japan: A panel study

Allergology International ◽

10.1016/j.alit.2015.10.002 ◽

2016 ◽

Vol 65 (2) ◽

pp. 147-152 ◽

Cited By ~ 12

Author(s):

Masanari Watanabe ◽

Hisashi Noma ◽

Jun Kurai ◽

Hiroyuki Sano ◽

Masaaki Mikami ◽

...

Keyword(s):

Pulmonary Function ◽

Panel Study ◽

Asian Dust ◽

Adult Asthma ◽

Asthma Patients ◽

Western Japan

Download Full-text

Variable expressed methylation sites of aging-related genes in asthma

10.21203/rs.3.rs-84789/v1 ◽

2020 ◽

Author(s):

Yu Yang ◽

Lin Yuan ◽

Ming Yang ◽

Xizi Du ◽

Ling Qin ◽

...

Keyword(s):

Pulmonary Function ◽

Mrna Expression ◽

Roc Curve ◽

Peripheral Blood ◽

Principal Component ◽

Mrna Levels ◽

Related Gene ◽

Cpg Sites ◽

Asthma Patients ◽

Dnam Level

Abstract Background: Asthma is a complex pulmonary inflammatory disease which is common in the elderly. Aging-related alterations have also been found in the structural cells and immune cells of asthma patients although the pathological mechanism of the differential aging-related gene in the development of asthma is still obscure. Of note, DNA methylation (DNAm) have been proven to play an important role in the regulation of aging-related genes. However, the methylation levels of aging-related genes in asthma patients are largely unclear.Methods: First, the mRNA levels and DNAm level of the previous screened 9 aging-related genes in peripheral blood of 51 healthy controls (HCs) and 55 asthmatic patients were detected by multiple targeted bisulfite enrichment sequencing (MethTarget) and qPCR. Secondly, the correlation between the DNAm level of specific altered CpG sites and the pulmonary function indicators of asthma patients was evaluated. Lastly, the Receiver Operator Characteristic (ROC) curve and Principal Component Analysis (PCA) were used to identify the feasibility of the candidate CpG sites as asthma markers.Results: The mRNA expression of the 9 aging-related gene in peripheral blood of asthma patients was significantly different from those of HCs. Besides, the methylation level of the 9 aging-related genes also altered in asthma patients, and a total of 68 CpG sites were related to the severity of asthma. Notably, 10 of the 68 CpG sites had a significant relationship with pulmonary function parameters. Moreover, ROC curve and PCA analysis showed that the candidate differential methylation sites (DMSs) can be used as potential biomarkers for asthma.Conclusions: In summary, this study confirmed the changes in the mRNA expression and DNAm level of aging-related genes in asthma patients. The differential DMSs are associated with the clinical evaluation indicators of asthma, which may indicate the involvement of aging-related genes in the pathogenesis of asthma and provide some new possible biomarker of asthma.

Download Full-text