Performance characterization of a whole body PET system designed for dynamic cardiac imaging

2002 ◽  
Author(s):  
D.C. Ficke ◽  
D.E. Beecher ◽  
S.R. Bergmann ◽  
G.R. Hoffman ◽  
J.T. Hood ◽  
...  
Keyword(s):  
Cardiac Imaging ◽  
Whole Body ◽  
Performance Characterization ◽  
Pet System

scholarly journals Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Philippe Thuillier ◽  
David Bourhis ◽  
Jean Philippe Metges ◽  
Romain Le Pennec ◽  
Karim Amrane ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Linear Relation ◽  
Whole Body ◽  
Pet Ct ◽  
Non Linear ◽  
Well Differentiated ◽  
Analog Systems ◽  
Pet System ◽  
Dynamic Acquisition ◽  
Linear Regressions

AbstractTo present the feasibility of a dynamic whole-body (DWB) 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB 68Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively included. The acquisition consisted in single-bed dynamic acquisition centered on the heart, followed by the DWB and static acquisitions. For liver, spleen and tumor (1–5/patient), Ki values (in ml/min/100 ml) were calculated according to Patlak's analysis and tumor-to-liver (TLR-Ki) and tumor-to-spleen ratios (TSR-Ki) were recorded. Ki-based parameters were compared to static parameters (SUVmax/SUVmean, TLR/TSRmean, according to liver/spleen SUVmean), in the whole-cohort and according to the PET system (analog/digital). A correlation analysis between SUVmean/Ki was performed using linear and non-linear regressions. Ki-liver was not influenced by the PET system used, unlike SUVmax/SUVmean. The regression analysis showed a non-linear relation between Ki/SUVmean (R2 = 0.55,0.68 and 0.71 for liver, spleen and tumor uptake, respectively) and a linear relation between TLRmean/TLR-Ki (R2 = 0.75). These results were not affected by the PET system, on the contrary of the relation between TSRmean/TSR-Ki (R2 = 0.94 and 0.73 using linear and non-linear regressions in digital and analog systems, respectively). Our study is the first showing the feasibility of a DWB 68Ga-DOTATOC-PET/CT acquisition in WD-NETs.

scholarly journals Performance Characterization of Composite Powders for 3D Printing

2021 ◽  
Vol 714 (3) ◽  
pp. 032070
Author(s):  
Xiangjun Bi ◽  
Hongjie Zhao ◽  
Yuanxun Gong ◽  
Xinghong Zhou
Keyword(s):  
3D Printing ◽  
Composite Powders ◽  
Performance Characterization

scholarly journals Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vidya Chandrasekaran ◽  
Giada Carta ◽  
Daniel da Costa Pereira ◽  
Rajinder Gupta ◽  
Cormac Murphy ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Retinoic Acid Receptor ◽  
Renal Proximal Tubule ◽  
Whole Body ◽  
Proper Function ◽  
Genome Wide ◽  
Glomerular Filtrate ◽  
Proximal Tubular ◽  
Induced Pluripotent

AbstractThe renal proximal tubule is responsible for re-absorption of the majority of the glomerular filtrate and its proper function is necessary for whole-body homeostasis. Aging, certain diseases and chemical-induced toxicity are factors that contribute to proximal tubule injury and chronic kidney disease progression. To better understand these processes, it would be advantageous to generate renal tissues from human induced pluripotent stem cells (iPSC). Here, we report the differentiation and characterization of iPSC lines into proximal tubular-like cells (PTL). The protocol is a step wise exposure of small molecules and growth factors, including the GSK3 inhibitor (CHIR99021), the retinoic acid receptor activator (TTNPB), FGF9 and EGF, to drive iPSC to PTL via cell stages representing characteristics of early stages of renal development. Genome-wide RNA sequencing showed that PTL clustered within a kidney phenotype. PTL expressed proximal tubular-specific markers, including megalin (LRP2), showed a polarized phenotype, and were responsive to parathyroid hormone. PTL could take up albumin and exhibited ABCB1 transport activity. The phenotype was stable for up to 7 days and was maintained after passaging. This protocol will form the basis of an optimized strategy for molecular investigations using iPSC derived PTL.

Design, Installation, and Performance Characterization of a Laboratory-Scale Solar Thermal System for Experiments in Solar Energy Utilization

2012 ◽  
Author(s):  
Stephanie Drozek ◽  
Christopher Damm ◽  
Ryan Enot ◽  
Andrew Hjortland ◽  
Brandon Jackson ◽  
...  
Keyword(s):  
Renewable Energy ◽  
Solar Energy ◽  
Laboratory Scale ◽  
Energy Utilization ◽  
Solar Thermal ◽  
Thermal System ◽  
Performance Characterization ◽  
And Performance ◽  
Solar Thermal System

The purpose of this paper is to describe the implementation of a laboratory-scale solar thermal system for the Renewable Energy Systems Laboratory at the Milwaukee School of Engineering (MSOE). The system development began as a student senior design project where students designed and fabricated a laboratory-scale solar thermal system to complement an existing commercial solar energy system on campus. The solar thermal system is designed specifically for educating engineers. This laboratory equipment, including a solar light simulator, allows for variation of operating parameters to investigate their impact on system performance. The equipment will be utilized in two courses: Applied Thermodynamics, and Renewable Energy Utilization. During the solar thermal laboratories performed in these courses, students conduct experiments based on the American Society of Heating, Refrigeration and Air-Conditioning Engineers (ASHRAE) 93-2010 standard for testing and performance characterization of solar thermal systems. Their measurements are then used to quantify energy output, efficiency and losses of the system and subsystem components.

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