Accurate Modeling of Multi Knife-edge Slit Collimator System Response for MeV Prompt Gamma Photons in Proton Therapy Monitoring

2018 ◽  
Author(s):  
Debin Zhang ◽  
Peng Fan ◽  
Wenzhuo Lu ◽  
Shi Wang ◽  
Yan Xia ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Therapy Monitoring ◽  
System Response ◽  
Prompt Gamma ◽  
Knife Edge ◽  
Slit Collimator ◽  
Edge Slit

scholarly journals Correction of Geometrical Effects of a Knife-Edge Slit Camera for Prompt Gamma-Based Range Verification in Proton Therapy

Instruments ◽  
2018 ◽  
Vol 2 (4) ◽  
pp. 25 ◽  
Author(s):  
Johannes Petzoldt ◽  
Guillaume Janssens ◽  
Lena Nenoff ◽  
Christian Richter ◽  
Julien Smeets
Keyword(s):  
Proton Therapy ◽  
Patient Treatment ◽  
Prompt Gamma ◽  
Knife Edge ◽  
Correction Model ◽  
System A ◽  
Safety Margins ◽  
Geometrical Effects ◽  
Edge Slit ◽  
Range Verification

Prompt gamma (PG) based range verification can potentially reduce the safety margins in proton therapy. A knife-edge slit camera has been developed in this context using analytical PG simulations as reference for absolute range verification during patient treatment. Geometrical deviations between measurement and simulation could be observed and have to be corrected for in order to improve the range retrieval of the system. A geometrical correction model is derived from Monte Carlo simulations in water. The influence of different parameters is tested and the model is validated in a dedicated benchmark experiment. We found that the geometrical correction improves the agreement between measured and simulated PG profiles resulting in an improved range retrieval and higher accuracy for absolute range verification. An intrinsic offset of 1.4 mm between measurement and simulation is observed in the experimental data and corrected in the PG simulation. In summary, the absolute range verification capabilities of a PG camera have been improved by applying a geometrical correction model.

scholarly journals Assessment of Geant4 Prompt-Gamma Emission Yields in the Context of Proton Therapy Monitoring

2016 ◽  
Vol 6 ◽  
Author(s):  
Marco Pinto ◽  
Denis Dauvergne ◽  
Nicolas Freud ◽  
Jochen Krimmer ◽  
Jean M. Létang ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Therapy Monitoring ◽  
Prompt Gamma ◽  
Gamma Emission
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