Chronological changes of skin eruptions toward cold abscess formation in hyper‐immunoglobulin E syndrome

Background: The presence of immunoglobulin E (IgE), which cross-reacts with allergen components, such as profilins, polcalcins, and cross-reacting carbohydrate determinants (CCD), creates a problem when selecting patients for allergen immunotherapy by using conventional methods. The aim of this study was to evaluate the prevalence of sensitization to profilins, polcalcins, and CCDs in patients with seasonal pollen allergic rhinitis. Methods: The study was performed on a group of 112 patients with seasonal pollen allergic rhinitis, ages 14 to 55 years, with sensitization to at least one seasonal allergen (IgE > 0.7 kUA/L). The presence of IgE sensitization to recombinant (r) Bet v 2, rPhl p 12, rBet v 4, rPhl p 7, and CCDs, in addition to rBet v 1, rPhl p 1, rPhl p 5, was evaluated by using a multiparameter immunoblot. Results: Among the studied patients, 64.3, 80.4, and 41.1% were sensitized to birch, timothy grass, and mugwort pollen, respectively. Sensitization to profilins rBet v 2/Phl p 12 was demonstrated in 28.6%, to polcalcins Bet v 4/Phl p 7 in 8.9%, and to CCDs in 25%. In 29.3%, serum IgE reactivity to any of the cross-reactive components could be demonstrated. Serum IgE reactivity to rBet v 2 was always accompanied by IgE reactivity to rPhl p 12, and IgE reactivity to rBet v 4 was always accompanied by IgE reactivity to rPhl p 7. Among the patients with pollinosis co-sensitized to at least two allergen sources according to extract-based diagnosis, possible false-positive results due to sensitization to cross-reactive components were detected in 17.9%. Conclusion: Evaluation of sensitization to cross-reacting components may be useful in evaluation of patients with pollen allergy who are being assessed for allergen immunotherapy to optimize the constitution of their immunotherapy vaccines.

Download Full-text

Prevention of food allergy

Allergy and Asthma Proceedings ◽

10.2500/aap.2019.40.4269 ◽

2019 ◽

Vol 40 (6) ◽

pp. 450-452 ◽

Cited By ~ 1

Author(s):

Ashley L. Devonshire ◽

Rachel Glick Robison

Keyword(s):

Food Allergy ◽

Peanut Allergy ◽

Immunoglobulin E ◽

Skin Prick Testing ◽

Clinical Manifestations ◽

Conclusive Evidence ◽

Severe Atopic Dermatitis ◽

Early Introduction ◽

Infant Diet ◽

Specific Immunoglobulin E

Primary prevention and secondary prevention in the context of food allergy refer to prevention of the development of sensitization (i.e., the presence of food-specific immunoglobulin E (IgE) as measured by skin-prick testing and/or laboratory testing) and sensitization plus the clinical manifestations of food allergy, respectively. Until recently, interventions that target the prevention of food allergy have been limited. Although exclusive breast-feeding for the first 6 months of life has been a long-standing recommendation due to associated health benefits, recommendations regarding complementary feeding in infancy have significantly changed over the past 20 years. There now is evidence to support early introduction of peanut into the diet of infants with egg allergy, severe atopic dermatitis, or both diagnoses, defined as high risk for peanut allergy, to try to prevent development of peanut allergy. Although guideline-based recommendations are not available for early introduction of additional allergenic foods, this topic is being actively studied. There is no evidence to support additional dietary modification of the maternal or infant diet for the prevention of food allergy. Similarly, there is no conclusive evidence to support maternal avoidance diets for the prevention of food allergy.

Download Full-text

Hubungan Antara Jenis Kelamin dan Riwayat Asma dengan Rinitis Alergi pada Pelajar SMP Muhammadiyah 3 Palembang

MEDICA ARTERIANA (Med-Art) ◽

10.26714/medart.2.1.2020.17-20 ◽

2020 ◽

Vol 2 (1) ◽

pp. 17

Author(s):

Meilina Wardhani ◽

Ressy Irma Juwita ◽

Mitayani Purwoko

Keyword(s):

Immunoglobulin E ◽

Cross Sectional ◽

Interleukin 5

Latar Belakang: Rinitis alergi adalah suatu penyakit pada hidung yang ditimbulkan oleh reaksi inflamasi mpada mukosa hidung dengan perantara immunoglobulin E. Prevalensi rinitis alergi di dunia telah meningkat termasuk di Indonesia yang kini telah mencapai 1,5-12.4% dan cenderung mengalami peningkatan setiap tahunnya. Penelitian ini bertujuan untuk mencari prevalensi rinitis alergi dan hubungan antara jenis kelamin dan riwayat asma dengan kejadian rinitis alergi pada siswa sekolah di Palembang. Metode: Penelitian ini adalah penelitian analitik observasional dengan desain cross sectional. Penelitian dilakukan di SMP Muhammadiyah 3 Palembang pada tahun 2018. Data primer diperoleh dengan cara meminta subjek penelitian untuk mengisi kuesioner ISAAC. Kriteria inklusi penelitian ini adalah siswa-siswi berusia 13-14 tahun. Besar sampel yang digunakan sebanyak 80 responden, diambil teknik total sampling.Hasil: Pada penelitian ini didapatkan prevalensi rinitis alergi sebesar 51,2% dan jenis kelamin (p=0,014) dan riwayat asma (p=0,019) sebagai faktor risiko terjadinya rinitis alergi. Perempuan lebih banyak menderita rinitis alergi dibanding laki-laki kemungkinan disebabkan perempuan lebih sering terpapar allergen berupa debu akibat sering melakukan pekerjaan rumah tangga seperti menyapu. Adanya paparan alergen terhadap mukosa hidung akan meningkatkan konsentrasi berbagai faktor yang terkait asma seperti eosinophil, interleukin-5 dan sel CD34 di darah perifer. Kesimpulan: Jenis kelamin dan riwayat asma merupakan faktor risiko terjadinya rinitis alergi pada anak.

Download Full-text