Performance of prenatal screening using maternal serum and ultrasound markers for Down syndrome in Chinese women: a systematic review and meta-analysis

Objective: There is a high prevalence of obstructive sleep apnea (OSA) in pediatric and adult Down Syndrome (DS) patients that is refractory to adenotonsillectomy and continuous positive airway pressure. Newer treatment modalities have emerged with improved outcomes. The objective is to provide an updated systematic review and meta-analysis to analyze the clinical outcomes of OSA in pediatric and adult DS patients with hypoglossal nerve stimulation using Inspire, midline posterior glossectomy plus lingual tonsillectomy (MPG + LT), and combined genioglossus advancement plus radiofrequency (GGS + RF). Methods: A comprehensive literature search of PubMed and Google Scholar was performed followed by a meta-analysis. Studies with preoperative and post-operative Apnea Hypopnea Index (AHI) values were included with patients serving as their own control. Results: Across 5 studies, 56 patients were analyzed. The mean reduction in AHI was statistically significant before vs. after procedure ( P < .001 for hypoglossal nerve stimulation using Inspire with a paired 2-tailed t-test and P = .031 for MPG + LT). Although individual patient AHI values were unavailable in the GGS + RF study, the standard difference in mean AHI was also significant for GGS + RF with P = .001. Device malfunction was the most common complication for Inspire while postoperative bleeding was observed for MPG + LT and nasopharyngeal obstruction and retropalatal collapse were observed for GGS + RF. Conclusion: This review reveals significant improvement in AHI with Inspire, MPG + LT, and GGS + RF for DS patients with refractory OSA. Further investigation is needed for comparison between these 3 therapies.

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Prevalence of metabolic syndrome in Chinese women and men: a systematic review and meta-analysis of data from 734 511 individuals

The Lancet ◽

10.1016/s0140-6736(18)32643-6 ◽

2018 ◽

Vol 392 ◽

pp. S14

Author(s):

Junjie Huang ◽

Jason LW Huang ◽

Mellissa Withers ◽

Kuo-Liong Chien ◽

Indang Trihandini ◽

...

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Chinese Women ◽

Meta Analysis

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A prospective trial of prenatal screening for Down syndrome by means of maternal serum α-fetoprotein, human chorionic gonadotropin, and unconjugated estriol

American Journal of Obstetrics and Gynecology ◽

10.1016/0002-9378(93)90613-n ◽

1993 ◽

Vol 169 (3) ◽

pp. 526-530 ◽

Cited By ~ 50

Author(s):

Barbara K. Burton ◽

Gail S. Prins ◽

Marion S. Verp

Keyword(s):

Down Syndrome ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Prenatal Screening ◽

Prospective Trial ◽

Maternal Serum ◽

Unconjugated Estriol

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Heart rate variability in individuals with Down syndrome – A systematic review and meta-analysis

Autonomic Neuroscience ◽

10.1016/j.autneu.2018.05.006 ◽

2018 ◽

Vol 213 ◽

pp. 23-33 ◽

Cited By ~ 9

Author(s):

Tatiana Dias de Carvalho ◽

Thais Massetti ◽

Talita Dias da Silva ◽

Tânia Brusque Crocetta ◽

Regiani Guarnieri ◽

...

Keyword(s):

Systematic Review ◽

Heart Rate ◽

Heart Rate Variability ◽

Down Syndrome ◽

Meta Analysis

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Maternal serum irisin levels in normotensive and preeclamptic pregnancies: a systematic review and meta-analysis

Gynecological Endocrinology ◽

10.1080/09513590.2021.2025217 ◽

2022 ◽

pp. 1-8

Author(s):

Kumar Vivek ◽

Balachandar Thangappazham ◽

Alekya Vykunta ◽

Paresh P. Kulkarni ◽

Faustino R. Pérez-López ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Maternal Serum

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Association between abnormal maternal serum levels of vitamin B12 and preeclampsia: a systematic review and meta-analysis

Nutrition Reviews ◽

10.1093/nutrit/nuaa096 ◽

2020 ◽

Author(s):

Farzaneh Mardali ◽

Somaye Fatahi ◽

Maryam Alinaghizadeh ◽

Hamed Kord Varkaneh ◽

Mohammad Hassan Sohouli ◽

...

Keyword(s):

Systematic Review ◽

Vitamin B12 ◽

Pregnant Women ◽

Data Extraction ◽

Meta Analysis ◽

Serum Vitamin ◽

Serum Levels ◽

Folic Acid Supplementation ◽

Maternal Serum ◽

Study Selection

Abstract Context Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear. Objective The aim of this systematic review was to compare serum vitamin B12 levels in women with preeclampsia with those in normotensive pregnant women. Data Sources The PubMed/MEDLINE, Scopus, and Web of Science databases were searched up to August 2019, along with the reference lists of included articles. Study Selection The literature was searched for observational studies that investigated vitamin B12 levels in women with preeclampsia. Data Extraction Data were extracted independently by 2 authors. Data were pooled using a random-effects model. Results Vitamin B12 levels in women with preeclampsia were significantly lower than those in healthy women (mean, −15.24 pg/mL; 95%CI, −27.52 to −2.954; P < 0.015), but heterogeneity between studies was high (I2 = 97.8%; P = 0.0103). Subgroup analyses based on folic acid supplementation, homocysteine concentrations, and gestational age at the time of sampling for vitamin B12 assessment did not identify the sources of heterogeneity. Conclusions Women with preeclampsia had significantly lower vitamin B12 concentrations than normotensive pregnant women.

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