Effectiveness of peroral endoscopic myotomy in the treatment of achalasia: A pilot trial in Chinese Han population with a minimum of one-year follow-up

2014 ◽  
Vol 15 (7) ◽  
pp. 352-358 ◽  
Author(s):  
Ting Sheng Ling ◽  
Hui Min Guo ◽  
Tian Yang ◽  
Chun Yan Peng ◽  
Xiao Ping Zou ◽  
...  
Keyword(s):  
Pilot Trial ◽  
Peroral Endoscopic Myotomy ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Endoscopic Myotomy ◽  
One Year

scholarly journals Single-session endoscopic fundoplication after peroral endoscopic myotomy (POEM+F) for prevention of post gastroesophageal reflux – 1-year follow-up study

Endoscopy ◽  
2020 ◽  
Author(s):  
Amol Bapaye ◽  
Parag Dashatwar ◽  
Siddharth Dharamsi ◽  
Rajendra Pujari ◽  
Harshal P Gadhikar
Keyword(s):  
Gastroesophageal Reflux ◽  
Peroral Endoscopic Myotomy ◽  
P Value ◽  
Prior Therapy ◽  
Eckardt Score ◽  
Single Center Study ◽  
Endoscopic Myotomy ◽  
Endoscopic Fundoplication ◽  
One Year

Background and Aim Peroral endoscopic myotomy (POEM) is an established treatment for achalasia cardia (AC), however post-POEM gastroesophageal reflux (GER) remains a significant problem. Concomitant endoscopic fundoplication following POEM (POEM+F) was recently described to reduce post-POEM GER. This single-center study reports medium-term outcomes of POEM+F. Patients and Methods Retrospective analysis of prospectively maintained database of patients undergoing POEM+F. Abstracted data – demographics, achalasia type, pre-POEM Eckardt score (ES), prior therapy, follow-up. Follow-up was 3-monthly for one-year. Follow-up assessments included post-POEM ES, GerdQ score, EGD – wrap integrity and esophagitis, and pH studies. GER was defined according to Lyon consensus. Data was recorded as mean (SD) or median (IQR), P-value < 0.05 was considered statistically significant. Results 25 patients underwent POEM+F, mean age (SD) – 40.13 (13.66) years, 12 females. POEM+F was technically successful in 23/25 (92%). Significant dysphagia improvement was seen in all 25 (mean [SD] pre- and post-POEM ES 8.21 [1.08] and 0.1 [0.3] respectively, p < 0.05). Mean total procedure and fundoplication time (SD) – 115.6 (27.2) and 46.7 (12.4) minutes respectively. Time reduced significantly after initial 5 cases. Median follow-up was 12-months (IQR 9 – 13). Intact wrap was seen in 19/23 (82.6%). GER (abnormal EAET) was seen in 2/18 (11.1%); one reported GerdQ > 8. Borderline GER (asymptomatic grade A esophagitis, normal EAET) was identified in 4/22 (18.1%). Two (8%) minor delayed adverse events required no intervention. Conclusions POEM+F is safe and reproducible. At 12-months follow-up, incidence of post-POEM+F GER was low and acceptable.

scholarly journals Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

2020 ◽  
Author(s):  
Jigao Feng ◽  
Yibin Ouyang ◽  
Dedong Xu ◽  
Qinglong He ◽  
Dayuan Liu ◽  
...  
Keyword(s):  
Progression Free Survival ◽  
Chinese Han Population ◽  
Migration And Invasion ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Kaplan Meier ◽  
Hazard Ratios

Abstract BackgroundlncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear.MethodsIn the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan–Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs.ResultsWe found that rs7318578 (OR = 2.25, p = 3.18x10-5) was significantly associated with glioma susceptibility in the overall participants. In the subgroup with age < 40 years, rs17735387 (OR = 1.53, p = 9.05x10-3) and rs7336610 (OR = 1.35, p = 0.016) were related to the higher glioma susceptibility. More importantly, rs17735387 (HR = 0.82, log-rank p = 0.026) were associated with the longer survival of glioma patients. The GA genotype of rs17735387 had a better overall survival (HR = 0.75, log-rank p = 0.013) and progression free survival (HR = 0.73, log-rank p = 0.032) in patients with Ⅰ-Ⅱ glioma. We also found that rs72640334 was related to the poor prognosis (HR = 1.49, Log-rank p = 0.035) in female patients. In the subgroup of patients with age ≥ 40 years, rs17735387 was associated with a better prognosis (HR = 0.036, Log-rank p = 0.002).ConclusionOur study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis. In subsequent studies, we will continue to collect samples and follow up to further validate our findings and further explore the function of these MIR17HG SNPs in glioma in a larger sample size.

scholarly journals One year comprehensive prospective follow-up of achalasia patients after peroral endoscopic myotomy

2021 ◽  
Vol 53 (1) ◽  
pp. 2225-2233
Author(s):  
Helge Evensen ◽  
Milada Cvancarova Småstuen ◽  
Anselm Schulz ◽  
Vendel Kristensen ◽  
Lene Larssen ◽  
...  
Keyword(s):  
Peroral Endoscopic Myotomy ◽  
Endoscopic Myotomy ◽  
One Year

scholarly journals Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jigao Feng ◽  
Yibin Ouyang ◽  
Dedong Xu ◽  
Qinglong He ◽  
Dayuan Liu ◽  
...  
Keyword(s):  
Progression Free Survival ◽  
Chinese Han Population ◽  
Migration And Invasion ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Kaplan Meier ◽  
Hazard Ratios

Abstract Background lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear. Methods In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan–Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs. Results We found that rs7318578 (OR = 2.25, p = 3.18 × 10− 5) was significantly associated with glioma susceptibility in the overall participants. In the subgroup with age <  40 years, rs17735387 (OR = 1.53, p = 9.05 × 10− 3) and rs7336610 (OR = 1.35, p = 0.016) were related to the higher glioma susceptibility. More importantly, rs17735387 (HR = 0.82, log-rank p = 0.026) were associated with the longer survival of glioma patients. The GA genotype of rs17735387 had a better overall survival (HR = 0.75, log-rank p = 0.013) and progression free survival (HR = 0.73, log-rank p = 0.032) in patients with I-II glioma. We also found that rs72640334 was related to the poor prognosis (HR = 1.49, Log-rank p = 0.035) in female patients. In the subgroup of patients with age ≥ 40 years, rs17735387 was associated with a better prognosis (HR = 0.036, Log-rank p = 0.002). Conclusion Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis. In subsequent studies, we will continue to collect samples and follow up to further validate our findings and further explore the function of these MIR17HG SNPs in glioma in a larger sample size.

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