Indo-Asian Collision: Transition from Compression to Lateral Escape Tectonics

2013 ◽  
Vol 87 (s1) ◽  
pp. 112-184 ◽  
Author(s):  
Zhiqin XU ◽  
Jean-Pierre BURG ◽  
Qin WANG ◽  
Haibing LI
Keyword(s):  
Escape Tectonics ◽  
Lateral Escape

scholarly journals A SUÍTE CÓRREGO TAQUARI NO ANTICLINAL DE ITACAMBIRA, BACIA DO RIO MACAÚBAS (MG): MAGMATISMO BÁSICO TARDI-EDIACARANO (CA. 560 MA) NO DOMÍNIO EXTERNO DO ORÓGENO ARAÇUAÍ

2013 ◽  
Author(s):  
Maximiliano Martins ◽  
Marly Babinsk ◽  
Carlos Maurício Noce ◽  
Gláucia Nascimento Queiroga ◽  
Antônio Carlos Pedrosa-Soares ◽  
...  
Keyword(s):  
Small Population ◽  
Mafic Magmatism ◽  
Fold And Thrust Belt ◽  
Minas Gerais State ◽  
Facies Metamorphism ◽  
Escape Tectonics ◽  
Lateral Escape ◽  
Araçuaí Orogen ◽  
Method Show ◽  
Greenschist Facies Metamorphism

No setor central do cinturão de dobramentos e empurrões da Serra do Espinhaço, domínio externo ocidental do Orógeno Araçuaí, situa-se o Anticlinal de Itacambira onde foi identificado um conjunto de diques gabróicos, pouco deformados e metamorfisados na fácies xisto verde. Um desses diques, englobados na Suíte Metaígnea Córrego do Taquari, tem assinatura litoquímica de toleíito intraplaca, idade-modelo Sm-Nd (TDM) em torno de 1,8 Ga e épsilon Nd negativo. Deste dique extraiu-se grãos de zircão para datação pelo método U-Pb (SHRIMP). Alguns destes grãos são herdados e evidenciam assimilação de cristais de zircão do Paleoproterozóico e Mesoproterozóico. A maior parte dos grãos são cristais euédricos, magmáticos, e suas análises U-Pb resultaram na idade de 560 ± 6 Ma para a cristalização magmática da Suíte Córrego Taquari. Esta suíte registra um sítio transtensivo formado e preenchido pelo magma máfico no limiar dos estágios sincolisional e tardi-colisional do Orógeno Araçuaí, provavelmente relacionado ao início dos fenômenos de escape lateral que afetaram este orógeno.Palavras-chave: diques máficos, Ediacarano, Orógeno AraçuaíABSTRACT: THE CÓRREGO TAQUARI SUITE IN THE ITACAMBIRA ANTICLINE, MACAÚBAS RIVER BASIN, MINAS GERAIS STATE: LATE EDIACARAN (CA. 560 MA) MAFIC MAGMATISM IN THE EXTERNAL TECTONIC DOMAIN OF THE ARAÇUAÍ OROGEN. In the central sector of the Serra do Espinhaço fold-and-thrust belt, western tectonic domain of the Neoproterozoic Araçuaí orogen, occurs the Itacambira anticline where a swarm of Late Ediacaran metamafic bodies were recently discovered, the Córrego Taquari meta-igneous suite. Most of these bodies occur as dykes cutting across units of the Espinhaço Supergroup and Macaúbas Group, and show incipient deformation and low greenschist facies metamorphism. The lithochemical and Sm-Nd isotopic data (negative epsilon Nd and TDM model age around 1.8 Ga) point to a tholeiitic intraplate signature. Twenty two zircon grains, extracted from a sample of a gabbroic dyke and analysed by the U-Pb (SHRIMP) method, show a small population of Paleoproterozoic and Mesoproterozoic inherited grains, and a major population of magmatic euhedral crystals. The less discordant, euhedral zircon crystals yielded the U-Pb (SHRIMP) age of 560 ± 6 Ma for the magmatic crystallization age of the Córrego Taquari Suite. This mafic magmatism records a Late Ediacaran extensional episode, probably related to the beginning of the lateral escape tectonics that took place in the late collisional stage of the Araçuaí orogen.Keywords: mafic dykes, Ediacaran, Araçuaí Orogen

scholarly journals Late Ediacaran lateral-escape tectonics as recorded by the Patos shear zone (Borborema Province, NE Brazil)

2021 ◽  
Vol 51 (2) ◽  
Author(s):  
Carlos José Archanjo ◽  
Maria Helena Bezerra Maia de Hollanda ◽  
Luis Gustavo Ferreira Viegas
Keyword(s):  
Shear Zone ◽  
Borborema Province ◽  
Escape Tectonics ◽  
Lateral Escape

PRE- AND SYN-KINEMATIC P-T CONSTRAINTS ACROSS A ZONE OF TRANSPRESSION, VERTICAL EXTRUSION, AND LATERAL ESCAPE IN THE SOUTHERN NEW ENGLAND APPALACHIANS

2017 ◽  
Author(s):  
Matthew A. Massey ◽  
◽  
Christopher A. Berg ◽  
David P. Moecher
Keyword(s):  
New England ◽  
Southern New England ◽  
Lateral Escape

Contrasting styles of convergence in the Arabia-Eurasia collision: Why escape tectonics does not occur in Iran

2006 ◽  
Author(s):  
Mark B. Allen ◽  
Eric J.-P. Blanc ◽  
Richard Walker ◽  
James Jackson ◽  
Morteza Talebian ◽  
...  
Keyword(s):  
Escape Tectonics

The Novel BCR-ABL1 V304D Mutation Induces Pan-Tyrosine Kinase Inhibitor Resistance by a Unique Kinase Lateral Escape Mechanism and Is Associated with Very Poor Prognosis In Patients (PTS) with Chronic Myeloid Leukemia (CML).

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3402-3402
Author(s):  
Sabrina Pricl ◽  
Don L Gibbons ◽  
Paola Posocco ◽  
Erik Laurini ◽  
Maurizio Fermeglia ◽  
...  
Keyword(s):  
Binding Site ◽  
Research Funding ◽  
Poor Prognosis ◽  
Binding Pocket ◽  
Activation Loop ◽  
Wild Type ◽  
Tki Resistance ◽  
Ic50 Values ◽  
Lateral Escape ◽  
Free Energy Of Binding

Abstract Abstract 3402 We discovered a novel BCR-ABL1 mutation (V304D) in pts with CML failing imatinib by DNA expansion of specific clones followed by DNA sequencing of ≥10 clones. BCR-ABL1V304D was detected in a median of 37% (range, 20% to 80%) resistant clones from 13 (18%) of 70 imatinib-resistant pts with CML in chronic phase (CP). Pts received imatinib for a median of 35 months (range 2 to 66) at doses ≥600 mg/d. No pt achieved a cytogenetic response. Four received nilotinib: 3 had hematologic resistance and 1 progressed to blast phase (BP). All pts died with negligible response to second-line TKIs: 8/12 pts on dasatinib had disease progression and 4 responded (2 hematologic and 2 transient minor cytogenetic responses). BCR-ABL1V304D failed to induce cytokine-independence or activate Stat5 in Ba/F3 cells. Phosphorylation of CrkL and specific BCR-ABL1 substrates were detectable but diminished compared to unmutated BCR-ABL1-transduced cells. BCR-ABL1V304D failed to catalyze autophosphorylation and the catalytic domain of ABL1V304D demonstrated deficient kinase activity. Enforced expression of BCR-ABL1V304Din CML cells induced quiescence and protection from imatinib-induced apoptosis. In vitro analyses of cells from a pt in CP expressing BCR-ABL1V304D in 50% of clones failed to detect CrKL phosphorylation in the presence of normal BCR-ABL1 protein levels, suggesting that BCR-ABL1V304D encodes a kinase-deficient protein and is associated with remarkable TKI resistance and extremely poor prognosis. To determine the mechanism of resistance imposed by BCR-ABL1V304D, we modeled this mutation in water and counterions and compared it to unmutated and mutant BCR-ABL1 isoforms. We first correlated the free energy of binding (DGbind) to the corresponding IC50 (DGbind = -RT lnIC50) and calculated the difference in free energy of binding between wild-type and mutant kinases (DDGbind = DGbind(WT) – DGbind(MUT)). DGbind <0 indicates a tighter binding to a TKI of the unmutated kinase relative to the mutant kinase. A negative increase of 1.4 kcal/mol in DGbind corresponds to a decrease by a factor of 10 in the IC50 value. The DGbind (IC50) values of imatinib for wild-type, Y253H, and T315I kinases were -10.47kcal/mol (21nM), -7.45 kcal/mol (3.4mM), and -6.38 kcal/mol (21mM), similar to published experimental data (25nM, 1.8–3.9mM, and >10mM, respectively), thus validating our modeling. DGbind and IC50 values for imatinib and dasatinib against V304D are -9.86kcal/mol (59nM) and -12.27 kcal/mol (1.02nM), respectively. 3D images generated from an equilibrated frame of 10 ns molecular dynamics (MD) simulations demonstrated that the 304 position is not in direct contact with imatinib, nor does it directly alter imatinib binding. Rather, V304D disturbs the position of the regulatory αC helix (Figure1). Longer standard molecular dynamics simulations coupled with steered MD recipes indicate that V304D induces a rearrangement of the ATP/drug binding pocket and water-mediated disruption of some fundamental hydrogen bonds regulating the transition of the activation loop to a “semi-open” conformation and the apt overall conformation of the SH3-binding segment of the TK (residues K294-F311). Furthermore, a decrease in the number of total interactions causes unidirectional drug translation toward the binding site exit. Iterative simulations revealed significant ATP/inhibitor diversion with subsequent complete imatinib expulsion. Thus, the V304D-induced semi-opened conformation of the activation loop favors 1) the lateral escape of imatinib, thus increasing the rate of TKI dissociating from the kinase and 2) does not allow the passage of ATP to reach deep into the binding pocket, thus hampering tyrosine phosphorylation. A similar phenomenon is observed in the activation loop in the active conformation of the V304D kinase bound to dasatinib, which results in greater exposure to water solvent of a part of the binding site and almost complete loss of hydrophobic contacts in the opposite end of the binding site. Fig. 1 MD snapshots of Imatinib (colored sticks) bound to (top) and “escaped” from (bottom) SCTABLIV304D. The mutant residue D304 is highlighted in yellow. Note the rearrangement of the activation loop, the SH3 binding region, and the helix C, colored blue, spring green, and orange in the lower panel. Some waters and counterions are shown as colored spheres. Fig. 1. MD snapshots of Imatinib (colored sticks) bound to (top) and “escaped” from (bottom) SCTABLIV304D. The mutant residue D304 is highlighted in yellow. Note the rearrangement of the activation loop, the SH3 binding region, and the helix C, colored blue, spring green, and orange in the lower panel. Some waters and counterions are shown as colored spheres. In summary, BCR-ABL1V304D results in kinase inactivation, pan-TKI resistance mediated by a novel mechanism of lateral escape at the kinase domain, less control of protein autoinhibition via perturbation of the SH3 binding domain and very poor prognosis. Complete modeling data against a panel of novel TKIs and potential modes of overcoming this novel mechanism of resistance will be presented. Disclosures: Kantarjian: Bristol Myers Squibb: Research Funding; ARIAD: Research Funding; Nerviano: Research Funding. Cortes:Bristol Myers Squibb: Research Funding; ARIAD: Research Funding; Nerviano: Research Funding.

Northwestern Overthrusting and Related Lateral Escape During the Brasiliano Orogeny North of the Patos Lineament, Borborema Province, Northeast Brazil

1997 ◽  
Vol 39 (7) ◽  
pp. 609-620 ◽  
Author(s):  
Peter Christian Hackspacher ◽  
Elton Luiz Dantas ◽  
Benjamin Bley Brito Neves ◽  
Jean Michel Legrand
Keyword(s):  
Northeast Brazil ◽  
Borborema Province ◽  
Brasiliano Orogeny ◽  
Lateral Escape

Himalayan-type escape tectonics along the Superior Boundary Zone in Manitoba, Canada

2011 ◽  
Vol 187 (3-4) ◽  
pp. 248-262 ◽  
Author(s):  
Yvette D. Kuiper ◽  
Shoufa Lin ◽  
Christian O. Böhm
Keyword(s):  
Boundary Zone ◽  
Escape Tectonics

scholarly journals Major shear zones of southern Brazil and Uruguay: escape tectonics in the eastern border of Rio de La plata and Paranapanema cratons during the Western Gondwana amalgamation

2010 ◽  
Vol 100 (2-3) ◽  
pp. 391-414 ◽  
Author(s):  
C. R. Passarelli ◽  
M. A. S. Basei ◽  
K. Wemmer ◽  
O. Siga ◽  
P. Oyhantçabal
Keyword(s):  
Shear Zones ◽  
Rio De La Plata ◽  
Southern Brazil ◽  
Río De La Plata ◽  
La Plata ◽  
Eastern Border ◽  
Escape Tectonics
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