Indocyanine green plasma disappearance rate as dynamic liver function test in critically ill patients

2014 ◽  
Vol 58 (10) ◽  
pp. 1214-1219 ◽  
Author(s):  
B. M. HALLE ◽  
T. D. POULSEN ◽  
H. P. PEDERSEN
Keyword(s):  
Liver Function ◽  
Indocyanine Green ◽  
Liver Function Test ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Disappearance Rate ◽  
Plasma Disappearance Rate ◽  
Function Test

Prognostic Value of the Indocyanine Green Plasma Disappearance Rate in Critically Ill Patients

CHEST Journal ◽  
2002 ◽  
Vol 122 (5) ◽  
pp. 1715-1720 ◽  
Author(s):  
Samir G. Sakka ◽  
Konrad Reinhart ◽  
Andreas Meier-Hellmann
Keyword(s):  
Indocyanine Green ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Prognostic Value ◽  
Disappearance Rate ◽  
Plasma Disappearance Rate

Evaluation of a transcutaneous method to assess canine liver function by indocyanine green plasma disappearance rate in healthy adult Beagle dogs

2016 ◽  
Vol 209 ◽  
pp. 169-173 ◽  
Author(s):  
A.P. Grobelna ◽  
J. Honkavaara ◽  
F. Restitutti ◽  
V. Huuskonen ◽  
S.G. Sakka ◽  
...  
Keyword(s):  
Liver Function ◽  
Indocyanine Green ◽  
Healthy Adult ◽  
Disappearance Rate ◽  
Beagle Dogs ◽  
Plasma Disappearance Rate

scholarly journals Indocyanine green plasma disappearance rate for assessment of liver function: re-evaluation of normal ranges and impact of biometric data

Critical Care ◽  
2013 ◽  
Vol 17 (S2) ◽  
Author(s):  
W Huber ◽  
M Kranzmayr ◽  
C Schultheiss ◽  
W Reindl ◽  
A Krug ◽  
...  
Keyword(s):  
Liver Function ◽  
Indocyanine Green ◽  
Disappearance Rate ◽  
Plasma Disappearance Rate ◽  
Biometric Data ◽  
Normal Ranges

scholarly journals Plasma Disappearance Rate of Indocyanine Green for Determination of Liver Function in Three Different Models of Shock

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 108 ◽  
Author(s):  
Alexander Mathes ◽  
Christopher Plata ◽  
Hauke Rensing ◽  
Sascha Kreuer ◽  
Tobias Fink ◽  
...  
Keyword(s):  
Liver Function ◽  
Indocyanine Green ◽  
Hemorrhagic Shock ◽  
Pharmacokinetic Models ◽  
Disappearance Rate ◽  
Sprague Dawley ◽  
Plasma Disappearance Rate ◽  
Compartment Models ◽  
Log Likelihood ◽  
Icg Clearance

The measurement of the liver function via the plasma disappearance rate of indocyanine green (PDRICG) is a sensitive bed-side tool in critical care. Yet, recent evidence has questioned the value of this method for hyperdynamic conditions. To evaluate this technique in different hemodynamic settings, we analyzed the PDRICG and corresponding pharmacokinetic models after endotoxemia or hemorrhagic shock in rats. Male anesthetized Sprague-Dawley rats underwent hemorrhage (mean arterial pressure 35 ± 5 mmHg, 90 min) and 2 h of reperfusion, or lipopolysaccharide (LPS) induced moderate or severe (1.0 vs. 10 mg/kg) endotoxemia for 6 h (each n = 6). Afterwards, PDRICG was measured, and pharmacokinetic models were analyzed using nonlinear mixed effects modeling (NONMEM®). Hemorrhagic shock resulted in a significant decrease of PDRICG, compared with sham controls, and a corresponding attenuation of the calculated ICG clearance in 1- and 2-compartment models, with the same log-likelihood. The induction of severe, but not moderate endotoxemia, led to a significant reduction of PDRICG. The calculated ICG blood clearance was reduced in 1-compartment models for both septic conditions. 2-compartment models performed with a significantly better log likelihood, and the calculated clearance of ICG did not correspond well with PDRICG in both LPS groups. 3-compartment models did not improve the log likelihood in any experiment. These results demonstrate that PDRICG correlates well with ICG clearance in 1- and 2-compartment models after hemorrhage. In endotoxemia, best described by a 2-compartment model, PDRICG may not truly reflect the ICG clearance.

scholarly journals Liver function assessment using indocyanine green plasma disappearance rate in a young male with icteric leptospirosis: a case report

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Alicja J. Kunikowska ◽  
Monika Wildgruber ◽  
Ewert Schulte-Frohlinde ◽  
Tobias Lahmer ◽  
Roland M. Schmid ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Function ◽  
Indocyanine Green ◽  
Young Male ◽  
Disappearance Rate ◽  
Plasma Disappearance Rate ◽  
Function Assessment
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