scholarly journals Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats

2018 ◽  
Vol 42 (2) ◽  
pp. 338-351 ◽  
Author(s):  
Kristin Feltmann ◽  
Dasiel Oscar Borroto-Escuela ◽  
Joëlle Rüegg ◽  
Luca Pinton ◽  
Thatiane de Oliveira Sergio ◽  
...  
Endocrine ◽  
2001 ◽  
Vol 14 (3) ◽  
pp. 329-336 ◽  
Author(s):  
Lucia Stefaneanu ◽  
Kalman Kovacs ◽  
Eva Horvath ◽  
Michael Buchfelder ◽  
Rudolf Fahlbusch ◽  
...  

1994 ◽  
Vol 18 (4) ◽  
pp. 1029-1031 ◽  
Author(s):  
E. K. G. Syvalahti ◽  
T. Pohjalainen ◽  
E. R. Korpi ◽  
E.-P. Palvimaki ◽  
T. Ovaska ◽  
...  

1991 ◽  
Vol 7 (2) ◽  
pp. 131-136 ◽  
Author(s):  
J. M. Johnston ◽  
D. F. Wood ◽  
E. A. Bolaji ◽  
D. G. Johnston

ABSTRACT Some pituitary tumours respond to dopamine by decreasing the release of prolactin and/or GH and by inhibition of tumour growth. Certain tumours are unresponsive. Dopamine D2 receptor high-affinity binding is impaired in these tumours, and the rat GH3 cell line behaves in a similar way. The hypothesis that the dopamine-binding defect results from impaired D2 receptor gene expression has been tested in the present study. On Northern blots, D2 receptor mRNA was present in both normal rat pituitary cells and in GH3 cells. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis identified a putative D2 receptor protein in normal and GH3 cell membranes. The lack of effect of dopamine in GH3 cells does not reflect the absence of D2 receptor gene expression.


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