Anxiety disorders comorbidity in pediatric bipolar disorder: a meta‐analysis and meta‐regression study

2020 ◽  
Vol 141 (4) ◽  
pp. 327-339 ◽  
Author(s):  
H. Yapıcı Eser ◽  
A. S. Taşkıran ◽  
B. Ertınmaz ◽  
T. Mutluer ◽  
Ö. Kılıç ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anxiety Disorders ◽  
Meta Analysis ◽  
Pediatric Bipolar Disorder ◽  
Meta Regression

Emotion regulation in pediatric bipolar disorder: A meta-analysis of published studies

2021 ◽  
Vol 285 ◽  
pp. 86-96
Author(s):  
Tatiana Cohab Khafif ◽  
Luisa de Siqueira Rotenberg ◽  
Camila Nascimento ◽  
Gabriel Henrique Beraldi ◽  
Beny Lafer
Keyword(s):  
Bipolar Disorder ◽  
Emotion Regulation ◽  
Meta Analysis ◽  
Pediatric Bipolar Disorder

scholarly journals ‘Pediatric Bipolar Disorder’ Rates are Still Lower than Claimed – A Re-examination of Eight Epidemiological Surveys used by an Updated Meta-analysis

2020 ◽  
Author(s):  
Peter Parry ◽  
Stephen Allison ◽  
Tarun Bastiampillai
Keyword(s):  
Bipolar Disorder ◽  
Narrative Analysis ◽  
Meta Analysis ◽  
Pediatric Bipolar Disorder ◽  
Bipolar Spectrum ◽  
Community Surveys ◽  
Bipolar Spectrum Disorder ◽  
Epidemiological Surveys ◽  
Highly Cited

Abstract Background: ‘Pediatric bipolar disorder’ (PBD) is a controversial diagnosis with varying rates of clinical diagnosis. A highly cited meta-analysis (Van Meter et al. 2011) of a dozen epidemiological surveys suggested a global community prevalence of 1.8%. This was further updated to 3.9% with eight additional surveys (Van Meter et al. 2019a). A narrative analysis (Parry et al. 2018) of the original 12 surveys concluded rates of PBD were substantially lower than 1.8% and led to a nine-article debate on the validity, overdiagnosis and iatrogenic aspects of the PBD diagnosis (e.g. Carlson and Dubicka 2019). This article extends the narrative analysis to include the eight newer community surveys.Methods: In terms of the Cochrane Handbook for Systematic Reviews of Interventions, the heterogenous community surveys were arguably unsuitable for statistical meta-analysis and warranted a narrative analysis.Results: Across all twenty surveys there was significant variation in methodologies and reported prevalence rates. Of the eight newer surveys, five (two Brazilian, one English, one Turkish, one United States) provided information of pre-adolescent rates of bipolar spectrum disorder. These pre-adolescent rates were zero or close to zero. Rates of adolescent hypomania/mania were higher, but follow-up data suggested most hypomania did not progress to adult bipolar disorder.Limitations: Methods in the original surveys vary and criteria used for various bipolar diagnoses were not always fully described. This limitation applies to a narrative analysis but also to a statistical meta-analysis.Conclusion: Bipolar disorder is very rare in childhood and rare in adolescence. PBD as a diagnostic construct fails to correlate with adult bipolar disorder and the term should be abandoned. Hypomanic syndromes in adolescence may not progress to adult bipolar disorder. Early diagnosis of bipolar disorder is important, but over-diagnosis risks adverse iatrogenic consequences.

Meta-Analysis of Epidemiologic Studies of Pediatric Bipolar Disorder

2011 ◽  
Vol 72 (09) ◽  
pp. 1250-1256 ◽  
Author(s):  
Anna R. Van Meter ◽  
Ana Lúcia R. Moreira ◽  
Eric A. Youngstrom
Keyword(s):  
Bipolar Disorder ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Pediatric Bipolar Disorder

Pharmacologic Treatments for Pediatric Bipolar Disorder: A Review and Meta-Analysis

2011 ◽  
Vol 50 (8) ◽  
pp. 749-762.e39 ◽  
Author(s):  
Howard Y. Liu ◽  
Mona P. Potter ◽  
K. Yvonne Woodworth ◽  
Dayna M. Yorks ◽  
Carter R. Petty ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Meta Analysis ◽  
Pediatric Bipolar Disorder ◽  
Pharmacologic Treatments

scholarly journals Prevalence and Associated Features of Anxiety Disorder Comorbidity in Bipolar Disorder: A Meta-Analysis and Meta-Regression Study

2018 ◽  
Vol 9 ◽  
Author(s):  
Hale Yapici Eser ◽  
Anil S. Kacar ◽  
Can M. Kilciksiz ◽  
Merve Yalçinay-Inan ◽  
Dost Ongur
Keyword(s):  
Bipolar Disorder ◽  
Anxiety Disorder ◽  
Meta Analysis ◽  
Meta Regression

scholarly journals Self-help treatment of anxiety disorders: A meta-analysis and meta-regression of effects and potential moderators

2012 ◽  
Vol 32 (5) ◽  
pp. 425-445 ◽  
Author(s):  
Thomas Haug ◽  
Tine Nordgreen ◽  
Lars Göran Öst ◽  
Odd E. Havik
Keyword(s):  
Anxiety Disorders ◽  
Meta Analysis ◽  
Self Help ◽  
Meta Regression

Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis

2016 ◽  
Vol 47 (6) ◽  
pp. 1107-1115 ◽  
Author(s):  
B. Pavlova ◽  
R. H. Perlis ◽  
O. Mantere ◽  
C. M. Sellgren ◽  
E. Isometsä ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Diagnostic Criteria ◽  
Meta Analysis ◽  
Fold Increase ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Increase Risk

BackgroundAnxiety disorders are highly prevalent in people with bipolar disorder, but it is not clear how many have anxiety disorders even at times when they are free of major mood episodes. We aimed to establish what proportion of euthymic individuals with bipolar disorder meet diagnostic criteria for anxiety disorders.MethodWe performed a random-effects meta-analysis of prevalence rates of current DSM-III- and DSM-IV-defined anxiety disorders (panic disorder, agoraphobia, social anxiety disorder, generalized anxiety disorder, specific phobia, obsessive–compulsive disorder, post-traumatic stress disorder, and anxiety disorder not otherwise specified) in euthymic adults with bipolar disorder in studies published by 31 December 2015.ResultsAcross 10 samples with 2120 individuals with bipolar disorder, 34.7% met diagnostic criteria for one or more anxiety disorders during euthymia [95% confidence interval (CI) 23.9–45.5%]. Direct comparison of 189 euthymic individuals with bipolar disorder and 17 109 population controls across three studies showed a 4.6-fold increase (risk ratio 4.60, 95% CI 2.37–8.92, p < 0.001) in prevalence of anxiety disorders in those with bipolar disorder.ConclusionsThese findings suggest that anxiety disorders are common in people with bipolar disorder even when their mood is adequately controlled. Euthymic people with bipolar disorder should be routinely assessed for anxiety disorders and anxiety-focused treatment should be initiated if indicated.

scholarly journals ‘Pediatric Bipolar Disorder’ rates are still lower than claimed: a re-examination of eight epidemiological surveys used by an updated meta-analysis

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Peter Parry ◽  
Stephen Allison ◽  
Tarun Bastiampillai
Keyword(s):  
Bipolar Disorder ◽  
Narrative Analysis ◽  
Meta Analysis ◽  
Pediatric Bipolar Disorder ◽  
Prevalence Rates ◽  
Community Surveys ◽  
Bipolar Spectrum Disorder ◽  
Epidemiological Surveys ◽  
Highly Cited

Abstract Background ‘Pediatric bipolar disorder’ (PBD) is a controversial diagnosis with varying rates of clinical diagnosis. A highly cited meta-analysis (Van Meter et al. 2011) of a dozen epidemiological surveys suggested a global community prevalence of PBD of 1.8%. This was updated to 3.9% with eight additional surveys (Van Meter et al. 2019a). In terms of the Cochrane Handbook for Systematic Reviews of Interventions, the heterogenous community surveys were arguably unsuitable for statistical meta-analysis and warranted a narrative analysis. A narrative analysis (Parry et al. 2018) of the original 12 surveys concluded rates of PBD were substantially lower than 1.8% and led to a nine-article debate on the validity, arguable overdiagnosis and iatrogenic aspects of the PBD diagnosis (e.g. Carlson and Dubicka Child Adolesc Mental Health 21:86–87, 2019). This article extends the narrative analysis to include the eight newer community surveys. Methods A narrative analysis of the methodologies and the prevalence rates reported by the epidemiological surveys. Results Across all twenty surveys there was significant variation in methodologies and reported prevalence rates. Of the eight newer surveys, five (two Brazilian, one English, one Turkish, one United States) provided information of pre-adolescent prevalence rates of bipolar spectrum disorder. These pre-adolescent rates were zero or close to zero. Rates of adolescent hypomania and mania were higher, but follow-up data in two studies suggested hypomania might sometimes achieve prolonged remission or not lead to adult bipolar disorder. Limitations Methods in the original surveys vary and criteria used for various bipolar diagnoses were not always fully described. This limitation applies to a narrative analysis but also to a statistical meta-analysis. Conclusion Bipolar disorder is very rare in childhood and rare in adolescence. PBD as a diagnostic construct fails to correlate with adult bipolar disorder and the term should be abandoned. Hypomanic syndromes in adolescence may not always progress to adult bipolar disorder. Early diagnosis of bipolar disorder is important, but over-diagnosis risks adverse iatrogenic consequences.

Sign in / Sign up

Export Citation Format

Share Document