scholarly journals Therapist and computer‐based brief interventions for drug use within a randomized controlled trial: effects on parallel trajectories of alcohol use, cannabis use and anxiety symptoms

Addiction ◽  
2019 ◽  
Vol 115 (1) ◽  
pp. 158-169
Author(s):  
Laura E. Drislane ◽  
Rebecca Waller ◽  
Meghan E. Martz ◽  
Erin E. Bonar ◽  
Maureen A. Walton ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Alcohol Use ◽  
Drug Use ◽  
Controlled Trial ◽  
Anxiety Symptoms ◽  
Brief Interventions ◽  
Cannabis Use ◽  
Randomized Controlled ◽  
Computer Based

scholarly journals CANreduce 2.0 – the effects of adherence-focused guidance for Internet self-help among cannabis misusers: results of a three-arm randomized controlled trial (Preprint)

2021 ◽  
Author(s):  
Christian Baumgartner ◽  
Michael Patrick Schaub ◽  
Andreas Wenger ◽  
Doris Malischnig ◽  
Mareike Augsburger ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Anxiety Symptoms ◽  
Cannabis Use ◽  
Cannabis Use Disorder ◽  
General Anxiety ◽  
Cannabis Dependence ◽  
Randomized Controlled ◽  
Self Help ◽  
Significant Difference

BACKGROUND Despite increasing demand for treatment among cannabis misusers in many countries, most misusers are not in treatment. Internet-based self-help offers an alternative for those hesitant to seek face-to-face therapy, though low-effectiveness and adherence issues often arise. Through adherence-focused guidance enhancement (AFGE), we aimed to increase adherence to, and the effectiveness of Internet-based self-help among cannabis misusers. OBJECTIVE A three-arm randomized controlled trial was conducted comparing the effectiveness of (1) an AFGE Internet-based self-help intervention with social presence (AFGE-SP), (2) a similar intervention with an impersonal service team (AFGE-ST), and (3) Internet access as usual (IAU, controls). METHODS From July 2016—May 2019, 575 cannabis misusers (70.6% males, mean age=28.3) not otherwise in treatment were recruited from the general population. The primary outcome was cannabis-use days over the preceding 30 days. Secondary outcomes included cannabis-dependence severity, changes in cannabis misuse disorder (CMD) symptoms, and intervention adherence. RESULTS All groups exhibited reduced cannabis-use days after 3 months (AFGE-SP: -8.2; AFGE-ST: -9.8; IAU: -4.2). AFGE-ST participants reported significantly fewer cannabis-use days than IAU controls (P = .01, d = .60); a similar reduction in the AFGE-SP (d=.40) group failed to achieve significance (P =.07). There was no significant difference between the two intervention groups. AFGE-ST patients also exhibited superior improvements in cannabis-use disorder, cannabis-dependence severity, and general anxiety symptoms after three months. CONCLUSIONS Adding an impersonal service team to the AFGE Internet-based self-help intervention significantly reduced cannabis use, cannabis use disorder, dependence severity, and general anxiety symptoms. CLINICALTRIAL http://www.isrctn.com/ISRCTN11086185

A randomized controlled trial of brief interventions to reduce drug use among adults in a low-income urban emergency department: the Healthi ER You study

Addiction ◽  
2017 ◽  
Vol 112 (8) ◽  
pp. 1395-1405 ◽  
Author(s):  
Frederic C. Blow ◽  
Maureen A. Walton ◽  
Amy S. B. Bohnert ◽  
Rosalinda V. Ignacio ◽  
Stephen Chermack ◽  
...  
Keyword(s):  
Emergency Department ◽  
Randomized Controlled Trial ◽  
Drug Use ◽  
Low Income ◽  
Controlled Trial ◽  
Brief Interventions ◽  
Randomized Controlled ◽  
Urban Emergency Department

scholarly journals Alcohol use severity and age moderate the effects of brief interventions in an emergency department randomized controlled trial

2019 ◽  
Vol 194 ◽  
pp. 386-394 ◽  
Author(s):  
Anne C. Fernandez ◽  
Rebecca Waller ◽  
Maureen A. Walton ◽  
Erin E. Bonar ◽  
Rosalinda V. Ignacio ◽  
...  
Keyword(s):  
Emergency Department ◽  
Randomized Controlled Trial ◽  
Alcohol Use ◽  
Controlled Trial ◽  
Brief Interventions ◽  
Randomized Controlled

scholarly journals Computer-based alcohol reduction intervention for alcohol-using HIV/HCV co-infected Russian women in clinical care: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ralph J. DiClemente ◽  
Jennifer L. Brown ◽  
Ariadna Capasso ◽  
Natalia Revzina ◽  
Jessica M. Sales ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Controlled Trial ◽  
Clinical Care ◽  
Standard Of Care ◽  
Randomized Controlled ◽  
Intervention Efficacy ◽  
Computer Based ◽  
Alcohol Reduction

Abstract Background Russia has a high prevalence of human immunodeficiency virus (HIV) infections. In 2018, over one million persons were living with HIV (PLWH); over a third were women. A high proportion of HIV-infected women are co-infected with hepatitis C virus (HCV), and many consume alcohol, which adversely affects HIV and HCV treatment and prognosis. Despite the triple epidemics of alcohol use, HIV and HCV, and the need for interventions to reduce alcohol use among HIV/HCV co-infected women, evidence-based alcohol reduction interventions for this vulnerable population are limited. To address this gap, we developed a clinical trial to evaluate the efficacy of a computer-based intervention to reduce alcohol consumption among HIV/HCV co-infected women in clinical care. Methods In this two-arm parallel randomized controlled trial, we propose to evaluate the efficacy of a culturally adapted alcohol reduction intervention delivered via a computer for HIV/HCV co-infected Russian women. The study population consists of women 21–45 years old with confirmed HIV/HCV co-infection who currently use alcohol. Intervention efficacy is assessed by a novel alcohol biomarker, ethyl glucuronide (EtG), and biomarkers of HIV and HCV disease progression. Women are randomized to trial conditions in a 1:1 allocation ratio, using a computer-generated algorithm to develop the assignment sequence and concealment of allocation techniques to minimize assignment bias. Women are randomized to either (1) the computer-based alcohol reduction intervention or (2) the standard-of-care control condition. We will use an intent-to-treat analysis and logistic and linear generalized estimating equations to evaluate intervention efficacy, relative to the standard of care, in enhancing the proportion of women with a laboratory-confirmed negative EtG at each research study visit over the 9-month follow-up period. Additional analyses will evaluate intervention effects on HIV (viral load and CD4+ levels) and HCV markers of disease progression (FibroScan). Discussion The proposed trial design and analysis provides an appropriate conceptual and methodological framework to assess the efficacy of the computer-based intervention. We propose to recruit 200 participants. The intervention, if efficacious, may be an efficient and cost-effective alcohol reduction strategy that is scalable and can be readily disseminated and integrated into clinical care in Russia to reduce women’s alcohol consumption and enhance HIV/HCV prognosis. Trial registration ClinicalTrials.gov NCT03362476. Registered on 5 December 2017

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