Cavernous artery intima‐media thickness predicts the response to sildenafil in erectile dysfunction patients as a morphological parameter

Andrologia ◽  
2021 ◽  
Author(s):  
Yuyang Zhang ◽  
Wang Zhou ◽  
Xu Wu ◽  
Guodong Liu ◽  
Yutian Dai ◽  
...  

Andrologia ◽  
2021 ◽  
Author(s):  
Khaled Fawzy El Mulla ◽  
Amr El Abd ◽  
Hanaa Mahmoud Donia ◽  
Reham Magdy Hussein ◽  
Amira Abulfotooh Eid


2009 ◽  
Vol 6 (4) ◽  
pp. 1117-1126 ◽  
Author(s):  
Nicola Caretta ◽  
Pierfrancesco Palego ◽  
Mirko Schipilliti ◽  
Alberto Ferlin ◽  
Antonella Di Mambro ◽  
...  


2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Bryan D Vo ◽  
Ehimen Aneni ◽  
Ebenezer Oni ◽  
Wazim Maziak ◽  
Theodore Feldman ◽  
...  

Introduction: A recent meta-analysis showed that erectile dysfunction (ED) was associated with elevated cardiovascular disease (CVD) mortality. However, findings from studies examining the relationship between ED and sub-clinical CVD have been conflicting. This study summarizes the current evidence related to the association of ED and vascular disease as measured by flow mediated dilation (FMD) of the endothelium and carotid intima media thickness (CIMT). Methods: We searched multiple internet databases for published literature on studies assessing the association of ED and FMD, and CIMT between 1964 and 2014. A total of 11 studies met the inclusion criteria for examining the association between ED and FMD, while 7 studies met criteria for assessing the association with CIMT. Fixed-effect and random-effect models were used to assess and compare the standardized mean difference (SMD) of FMD and CIMT between persons with and without ED. Results: From a total of 795 individual participant data (590 with and 205 without ED), persons with ED had a 0.66mm (0.49, 0.83) increase in CIMT by fixed effects model or 0.67mm (0.44, 0.90) by random effects model compared to those without ED. Similarly, from 1055 individual participant data (536 with and 419 without ED), ED was associated with a significant reduction in FMD by both fixed effect (-1.10% (95% CI: -2.10, -0.95)) and random effect models (-1.53% (95% CI: -2.10, -0.95)). There was significant heterogeneity among studies assessing the relationship between ED and FMD (I2 = 93.2%, p<0.001) but not among those comparing CIMT among persons with ED (I2 = 43.5% p=0.09). Conclusion: This study confirms that ED is associated with both worsening endothelial function and increased CIMT. Thus, worsening vascular function may be a pathogenic mechanism for increased CVD morbidity and mortality in persons with ED. A diagnosis of ED should prompt a thorough CV work-up and aggressive preventive management.





2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Cevdet Serkan Gökkaya ◽  
Binhan Kagan Aktas ◽  
Ugur Toprak ◽  
Sedat Yahsi ◽  
Suleyman Bulut ◽  
...  


Medicina ◽  
2020 ◽  
Vol 56 (10) ◽  
pp. 500 ◽  
Author(s):  
Radojica V. Stolic ◽  
Zoran Bukumiric ◽  
Branislav Belic ◽  
Bozidar Odalovic ◽  
Goran Relic ◽  
...  

Background and objectives: In patients on hemodialysis, erectile dysfunction is an independent mortality factor. This study aimed to determine the risk factors that affect the survival of hemodialysis patients with erectile dysfunction. Materials and Methods: During a seven-year period, erectile dysfunction was identified among the fatalities reported in patients receiving chronic hemodialysis, on the basis of the International Index of Erectile Function questionnaire. The study covered 70 patients of mean age 57 ± 6.7 years. During the examined period, 42 (60%) patients died at the mean age 57 ± 6.8 years. The study was completed by 28 (40%) patients, aged 57 ± 6.55 years. Laboratory, demographic, anthropometric, and clinical characteristics were recorded using standard methods. Results: Statistically significant differences between the two groups of respondents were found concerning dialysis duration (p < 0.001), number of leukocytes (p = 0.003), adequacy of hemodialysis (p = 0.004), intima media thickness of the carotid artery (p < 0.001), presence of cardiovascular disease (p = 0.03), residual diuresis (p = 0.04), and hemodiafiltration (p < 0.001). Hemodialysis adequacy (B = −9.634; p = 0.017), intima media thickness (B = 0.022; p = 0.003), residual diuresis (B = −0.060; p = 0.007), and lower rates of cardiovascular disease (B = 0.176; p = 0.034) were significant survival predictors among our patients with erectile dysfunction. Conclusions: Risk factors that are associated with improved survival of patients on hemodialysis with erectile dysfunction in our study are: preserved diuresis, high-quality hemodialysis, lower incidence of cardiovascular disease, and less thickening of the intima media of the carotid arteries.



2013 ◽  
Vol 7 (3-4) ◽  
pp. 116
Author(s):  
A. Angelis ◽  
N. Ioakimidis ◽  
K. Aznaourides ◽  
A. Agelakas ◽  
A. Samentzas ◽  
...  




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