scholarly journals Late‐onset hypogonadism: Reductio ad absurdum of the cardiovascular risk‐benefit of testosterone replacement therapy

Andrology ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 1614-1627 ◽  
Author(s):  
Franz Sesti ◽  
Riccardo Pofi ◽  
Marianna Minnetti ◽  
Marta Tenuta ◽  
Daniele Gianfrilli ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Replacement Therapy ◽  
Late Onset ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy ◽  
Reductio Ad Absurdum ◽  
Late Onset Hypogonadism

scholarly journals Benefits and Consequences of Testosterone Replacement Therapy: A Review

2010 ◽  
Vol 9 (1) ◽  
pp. 59
Author(s):  
Polackwich AS ◽  
Tadros NN ◽  
Ostrowski KA ◽  
◽  
◽  
...  
Keyword(s):  
Mental Health ◽  
Cardiovascular Risk ◽  
Adverse Effects ◽  
Replacement Therapy ◽  
Bone Health ◽  
Late Onset ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy ◽  
Late Onset Hypogonadism

Late onset hypogonadism (LOH) is an issue of increasing concern. Studies have shown the importance of testosterone in the maintenance of homeostasis, especially with respect to bone health, sexual function, diabetes, cardiovascular risk, mental health and cognition. Much of the dysfunction in hypogonadism can be reversed or improved with testosterone replacement therapy (TRT). Physicians worry about the possible consequences of TRT, especially regarding the prostate. By reviewing the literature, we have found there are significant benefits to TRT, and fears of adverse effects on the prostate are largely unfounded, though there is a great need for larger studies with longer periods of follow-up, especially to evaluate adverse events.

scholarly journals Short term testosterone replacement therapy improves libido and body composition

2009 ◽  
Vol 53 (8) ◽  
pp. 996-1004 ◽  
Author(s):  
Edésio Seara de Andrade Júnior ◽  
Ruth Clapauch ◽  
Salo Buksman
Keyword(s):  
Body Composition ◽  
Waist Circumference ◽  
Replacement Therapy ◽  
Late Onset ◽  
Testosterone Replacement ◽  
Testosterone Replacement Therapy ◽  
Efficacy And Safety ◽  
Short Term ◽  
Sf 36 ◽  
Late Onset Hypogonadism

OBJECTIVE: To assess the efficacy and safety of testosterone replacement in males with late-onset hypogonadism compared to hypogonadal men without replacement, and controls, during six months. METHODS: We assessed, through ADAM, AMS, IIEF-5 and SF-36 questionnaires, and through clinical and laboratorial examinations, 62 patients divided into three groups: 17 hypogonadal males (HR) used intramuscular testosterone every three weeks; 14 hypogonadal males (HV) and 31 non-hypogonadal males (CV) used oral vitamins daily. RESULTS: When compared to others, HR group obtained libido improvement assessed by ADAM 1 (p = 0.004), and borderline sexual potency improvement assessed by IIEF-5 (p = 0.053), besides a decrease in waist circumference after eight weeks (p = 0.018). The remaining parameters did not differ between the groups. PSA and hematocrit remained stable in those using testosterone. CONCLUSION: Six months of testosterone replacement improved sexuality and body composition, with prostatic and hematological safety.

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