scholarly journals Early‐stage endometrial cancer, CTNNB1 mutations, and the relation between lymphovascular space invasion and recurrence

2019 ◽  
Vol 99 (2) ◽  
pp. 196-203
Author(s):  
Sara Imboden ◽  
Coya Tapia ◽  
Nadja Scheiwiller ◽  
Vida Kocbek ◽  
Hans J. Altermatt ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Early Stage Endometrial Cancer ◽  
Lymphovascular Space Invasion

scholarly journals Adjuvant therapy for early stage, endometrial cancer with lymphovascular space invasion: Is there a role for chemotherapy?

2020 ◽  
Vol 156 (3) ◽  
pp. 568-574 ◽  
Author(s):  
Anna L. Beavis ◽  
Ting-Tai Yen ◽  
Rebecca L. Stone ◽  
Stephanie L. Wethington ◽  
Caitlin Carr ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Adjuvant Therapy ◽  
Early Stage ◽  
Early Stage Endometrial Cancer ◽  
Lymphovascular Space Invasion

Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer

2013 ◽  
Vol 123 (2) ◽  
pp. 142-145 ◽  
Author(s):  
Joel Laufer ◽  
Santiago Scasso ◽  
Andrea Papadia ◽  
Claudio Sosa ◽  
Federico Cirillo ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Tumor Diameter ◽  
Early Stage Endometrial Cancer ◽  
Lymphovascular Space Invasion

Lymphovascular Space Invasion for Endometrial Cancer: Undertreatment and Overtreatment Risks

2017 ◽  
Vol 27 (6) ◽  
pp. 1191-1199 ◽  
Author(s):  
Mikel Gorostidi Pulgar ◽  
Begoña Diaz de la Noval ◽  
Blanca Gil-Ibañez ◽  
Victor Lago Leal ◽  
Ibon Jaunarena Marin ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Knowledge Based ◽  
Gynecology And Obstetrics ◽  
Gynecology Oncology ◽  
The Impact ◽  
Early Stage Endometrial Cancer ◽  
Lymphovascular Space Invasion

ObjectiveThe purpose of this study is to asses the impact of lymphovascular space invasion (LVSI) present in early-stage endometrial cancer, regarding its therapeutic management and prognosis knowledge, based on a survey among Spanish oncologic gynecologist.Methods/MaterialsBetween October and November 2014, the Young Spanish Onco-gynecologist Group carried out a survey to perform a cross-sectional study about the management of LVSI. All active members in the oncology field of the Spanish Society of Gynecology and Obstetrics were invited to participate in the survey.ResultsMost respondents consider LVSI a bad prognosis factor for endometrial cancer (66%) and also consider that it should be included in the International Federation of Gynecology and Obstetrics classification (56%). Seventy-five percent of all gynecologists did not modify their surgical treatment. Regarding follow-up, 38% of the respondents do not change their surveillance, 28% modify it, and 31% reported any change only with additional factors. Forty-seven percent of respondents advise systemic treatment with chemotherapy.Data were dichotomized between less than or equal to 20 versus greater than 20 years of OB-GYN specialist and less than or equal to 5 versus greater than 5 years of main dedication to gynecology oncology, but it was not possible to show any significant differences among the groups. The response rate (34 individuals) was too low to expect any significant differences.ConclusionsResults suggest that LVSI remains a controversial issue in the management of patients with endometrial cancer. Acquiring a deeper knowledge and uniform criteria could avoid the risk of undertreatment and overtreatment in this group of patients with early-stage endometrial cancer. The identification of vascular pseudoinvasion is recommended, although the clinical and prognostic implications still need to be determined.

Prognostic Significance of Lymphovascular Space Invasion in the Absence of Lymph Node Metastases in Early-Stage Endometrial Cancer

2018 ◽  
Vol 28 (5) ◽  
pp. 890-894 ◽  
Author(s):  
Ellen Cusano ◽  
Victoria Myers ◽  
Rajiv Samant ◽  
Talia Sudai ◽  
Allison Keller ◽  
...  
Keyword(s):  
Overall Survival ◽  
Endometrial Cancer ◽  
Prognostic Factor ◽  
Early Stage ◽  
Prognostic Significance ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Node Negative ◽  
Early Stage Endometrial Cancer ◽  
Lymphovascular Space Invasion

ObjectiveLymphovascular space invasion (LVSI) has been defined as a significant adverse prognostic factor in early-stage endometrial cancer, primarily because of its high association with nodal metastases. This study aimed to determine if LVSI provides any prognostic significance in pathologic node-negative surgically staged (T1N0) endometrial cancer patients.Methods/MaterialsThis retrospective cohort study included all patients with pathologic stage T1N0 endometrial carcinoma treated at The Ottawa Hospital Cancer Centre from 1998 to 2007. Patient demographics, pathologic findings, treatment, and outcome data were collected. Univariate and multivariate cox regression modeling was used to assess significance and adjust for demographic and histopathologic covariates. Kaplan-Meier curves were used to estimate the 5-year overall and recurrence-free survival.ResultsOur study included 400 pathologic stage T1N0 patients who received an initial total hysterectomy and bilateral salpingo-oophorectomy with lymphadenectomy. The median age at diagnosis was 62 years, and the median follow-up was 66 months. Fifty-four patients (13.5%) had a positive LVSI status, and 346 (86.5%) had a negative LVSI status. The 5-year overall survival was 97.3% in patients without LVSI and 90.9% in those with LVSI (P < 0.001). The 5-year recurrence-free survival was 95.2% in patients without LVSI and 85.9% in those with LVSI (P = 0.006). Univariate analysis identified grade, stage, and LVSI as the covariates significantly associated with time to recurrence, and identified age, grade, stage, and LVSI to be significantly associated with overall survival. There were no significant covariates for recurrence-free survival by multivariate analysis, and only age and LVSI were significant for overall survival.ConclusionsLymphovascular space invasion is an overall poor prognostic factor in T1N0 endometrial cancer. After adjusting for other factors, LVSI remains an independent risk factor for worse overall survival. Therefore, estimation of overall survival in patients with early-stage, node-negative endometrial cancer should take into account LVSI status.

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