scholarly journals Hysterectomy after uterus transplantation and detailed analyses of graft failures

2021 ◽  
Author(s):  
Camilla C. Karlsson ◽  
Pernilla Dahm‐Kähler ◽  
Niclas Kvarnström ◽  
Johan Mölne ◽  
Verena Broecker ◽  
...  
Keyword(s):  
Uterus Transplantation

Research outcomes following uterus transplantation at Royal Prince Alfred Hospital

2020 ◽  
Vol 29 (3) ◽  
Author(s):  
Dana Georgevsky ◽  
Ying Li ◽  
Kate Wyburn ◽  
Selvan Pather ◽  
Trevor TejadaBerges ◽  
...  
Keyword(s):  
Uterus Transplantation ◽  
Royal Prince Alfred Hospital ◽  
Research Outcomes ◽  
Alfred Hospital

scholarly journals Preimplantation genetic testing for aneuploidy in uterus transplant patients

2021 ◽  
Vol 15 ◽  
pp. 263349412110098
Author(s):  
Rhea Chattopadhyay ◽  
Elliott Richards ◽  
Valerie Libby ◽  
Rebecca Flyckt
Keyword(s):  
Genetic Testing ◽  
In Vitro Fertilization ◽  
Immunosuppressive Agents ◽  
Live Birth Rate ◽  
Preimplantation Genetic Testing ◽  
Vitro Fertilization ◽  
Uterus Transplantation ◽  
Advantages And Disadvantages ◽  
Dilation And Curettage

Uterus transplantation is an emerging treatment for uterine factor infertility. In vitro fertilization with cryopreservation of embryos prior is required before a patient can be listed for transplant. Whether or not to perform universal preimplantation genetic testing for aneuploidy should be addressed by centers considering a uterus transplant program. The advantages and disadvantages of preimplantation genetic testing for aneuploidy in this unique population are presented. The available literature is reviewed to determine the utility of preimplantation genetic testing for aneuploidy in uterus transplantation protocols. Theoretical benefits of preimplantation genetic testing for aneuploidy include decreased time to pregnancy in a population that benefits from minimization of exposure to immunosuppressive agents and decreased chance of spontaneous abortion requiring a dilation and curettage. Drawbacks include increased cost per in vitro fertilization cycle, increased number of required in vitro fertilization cycles to achieve a suitable number of embryos prior to listing for transplant, and a questionable benefit to live birth rate in younger patients. Thoughtful consideration of whether or not to use preimplantation genetic testing for aneuploidy is necessary in uterus transplant trials. Age is likely a primary factor that can be useful in determining which uterus transplant recipients benefit from preimplantation genetic testing for aneuploidy.

scholarly journals May I have your uterus? The contribution of considering complexities preceding live uterus transplantation

2021 ◽  
pp. medhum-2020-011864
Author(s):  
Lisa Guntram
Keyword(s):  
Medical Humanities ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
In Vitro Fertilisation ◽  
Medical Innovation ◽  
Uterus Transplantation ◽  
Ethical Debate ◽  
Care And Support ◽  
Different Dimensions

Uterus transplantation combined with in vitro fertilisation (IVF) (henceforth called UTx-IVF) as a treatment for infertility caused by an absence or malfunction of the uterus is advancing. About 50 transplantations have been conducted worldwide and at least 14 children have been born—9 of them by women taking part in a Swedish research project on UTx-IVF. The Swedish research protocol initially stated that the potential recipient must ‘have her own donor’ who is preferably related to the recipient. But what does it mean to ask someone for a uterus? What challenges does this question instigate? And what norms may it enact? In this article, I explore how 10 women—who have considered, and sometimes pursued, UTx-IVF—describe their experiences of searching for a donor. I aim to show how an analysis of such accounts can help us unpack some of the specific relational and gendered dimensions of UTx-IVF and by doing so enrich discussions of risks, benefits, care and support in UTx-IVF. Drawing on research in social sciences and medical humanities that has demonstrated how assisted reproductive technologies and organ donation can provoke social and familial conundrums, with respect to such topics as embodiment and identity, I present three patterns that describe different dimensions of the interviewees’ quest for a uterus donor. I discuss the negotiations that took place, how expectations unfolded and how entanglements were managed as the interviewees considered asking someone for a donation. Such an examination, I suggest, contributes to make care and support more attuned to the experiences and entanglements that UTx-IVF entails for those pursuing it. This will become increasingly important if (or when) UTx-IVF becomes part of general healthcare. To conclude, I problematise responsibilities and relational challenges in medical innovation, and in this way provide insights into how the ethical debate over UTx-IVF can broaden its scope.

Pregnancy after CMV infection following uterus transplantation: A case report from the Dallas Uterus Transplant Study

2021 ◽  
Author(s):  
Matthew Rosenzweig ◽  
Anji Wall ◽  
Cedric W. Spak ◽  
Giuliano Testa ◽  
Liza Johannesson
Keyword(s):  
Case Report ◽  
Cmv Infection ◽  
Uterus Transplantation

Uterus transplantation

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Stefan G. Tullius
Keyword(s):  
Uterus Transplantation

Reproductive, Obstetrical and Long-Term Health Outcome after Uterus Transplantation: Results of the First Clinical Trial

2021 ◽  
Author(s):  
Mats Brannstrom ◽  
Pernilla Dahm-Kähler ◽  
Niclas Kvarnström ◽  
Anders Enskog ◽  
Jan Ingemar Olofsson ◽  
...  
Keyword(s):  
Health Outcome ◽  
Clinical Trial ◽  
Uterus Transplantation

scholarly journals Ethical and policy issues raised by uterus transplants

2019 ◽  
Vol 131 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Laura O’Donovan ◽  
Nicola Jane Williams ◽  
Stephen Wilkinson
Keyword(s):  
Deceased Donor ◽  
Access To Treatment ◽  
Policy Issues ◽  
Uterus Transplantation ◽  
Academic Literature ◽  
International Registry ◽  
Uterine Transplantation ◽  
Key Issues ◽  
Surgical Teams ◽  
Definition Of

Abstract Introduction In 2014, Brännström and colleagues reported the first human live birth following uterine transplantation (UTx). Research into this treatment for absolute uterine factor infertility has since grown with clinical trials currently taking place across centers in at least thirteen countries worldwide. Sources of data This review summarizes and critiques the academic literature on ethical and policy issues raised by UTx. Areas of agreement There is general agreement on the importance of risk reduction and, in principle, to the sharing and maintenance of patient data on an international registry. Areas of controversy There are numerous areas of controversy ranging from whether it is ethically justified to carry out uterus transplants at all (considering the associated health risks) to how deceased donor organs for transplant should be allocated. This review focuses on three key issues: the choice between deceased and living donors, ensuring valid consent to the procedure and access to treatment. Growing points UTx is presently a novel and rare procedure but is likely to become more commonplace in the foreseeable future, given the large number of surgical teams working on it worldwide. Areas timely for developing research Uterus transplantation requires us to re-examine fundamental questions about the ethical and social value of gestation. If eventually extended to transgender women or even to men, it may also require us to reconceptualize what it is to be a ‘father’ or to be a ‘mother’, and the definition of these terms in law.

Uterus transplantation from a deceased donor

The Lancet ◽  
2018 ◽  
Vol 392 (10165) ◽  
pp. 2657-2658 ◽  
Author(s):  
Cesar Diaz-Garcia ◽  
Antonio Pellicer
Keyword(s):  
Deceased Donor ◽  
Uterus Transplantation

Short Term Follow Up Results of the First Human Uterus Transplantation from Cadaver

2012 ◽  
Vol 19 (6) ◽  
pp. S83 ◽  
Author(s):  
M. Erman Akar ◽  
O. Ozkan ◽  
O. Ozkan ◽  
O. Erdogan ◽  
M. Cincik ◽  
...  
Keyword(s):  
Human Uterus ◽  
Short Term ◽  
Uterus Transplantation
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