Hyperoxic Condition Promotes an Inflammatory Response During Cardiopulmonary Bypass in a Rat Model

2013 ◽  
Vol 37 (12) ◽  
pp. 1034-1040 ◽  
Author(s):  
Yutaka Fujii ◽  
Mikiyasu Shirai ◽  
Hirotsugu Tsuchimochi ◽  
James T. Pearson ◽  
Yoshiaki Takewa ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Rat Model ◽  
Hyperoxic Condition

Insufflation of Hydrogen Gas Restrains the Inflammatory Response of Cardiopulmonary Bypass in a Rat Model

2012 ◽  
Vol 37 (2) ◽  
pp. 136-141 ◽  
Author(s):  
Yutaka Fujii ◽  
Mikiyasu Shirai ◽  
Shuji Inamori ◽  
Akito Shimouchi ◽  
Takashi Sonobe ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Rat Model ◽  
Hydrogen Gas

PHOSPHODIESTERASE TYPE 4 INHIBITOR ATTENUATES SYSTEMIC INFLAMMATORY RESPONSE INDUCED BY CARDIOPULMONARY BYPASS IN A RAT MODEL

ASAIO Journal ◽  
2004 ◽  
Vol 50 (2) ◽  
pp. 118
Author(s):  
M. Hamamoto ◽  
M. Suga ◽  
Y. Takahashi ◽  
Y. Sato ◽  
S. Inamori ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Rat Model ◽  
Systemic Inflammatory Response ◽  
Phosphodiesterase Type

Changes in mesenteric vascular reactivity and inflammatory response after cardiopulmonary bypass in a rat model

2004 ◽  
Vol 77 (6) ◽  
pp. 2130-2137 ◽  
Author(s):  
Fabien Doguet ◽  
Pierre-Yves Litzler ◽  
Fabienne Tamion ◽  
Vincent Richard ◽  
Marie-France Hellot ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Rat Model ◽  
Vascular Reactivity

Effect of Hydroxyethyl Starch Priming on the Systemic Inflammatory Response and Lung Edema after Cardiopulmonary Bypass in a Rat Model

ASAIO Journal ◽  
2017 ◽  
Vol 63 (5) ◽  
pp. 618-623 ◽  
Author(s):  
Yutaka Fujii ◽  
Takayuki Tanabe ◽  
Tsubasa Yamashiro ◽  
Mikiyasu Shirai ◽  
Yoshiaki Takewa ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Hydroxyethyl Starch ◽  
Rat Model ◽  
Systemic Inflammatory Response ◽  
Lung Edema

A novel rat model of cardiopulmonary bypass (CPB) with cardiac arrest and precise hemodynamic assessment by conductance catheter technique

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
R Guenzinger ◽  
SM Wildhirt ◽  
H Schad ◽  
W Heimisch ◽  
N Mendler ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Bypass ◽  
Rat Model ◽  
Conductance Catheter ◽  
Catheter Technique ◽  
Hemodynamic Assessment

Modulation of the inflammatory response to cardiopulmonary bypass by dopexamine and epidural anesthesia

2002 ◽  
Vol 46 (10) ◽  
pp. 1227-1235 ◽  
Author(s):  
F. Bach ◽  
U. Grundmann ◽  
M. Bauer ◽  
H. Buchinger ◽  
S. Soltész ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Epidural Anesthesia

scholarly journals Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Thiago Augusto Azevedo Maranhão Cardoso ◽  
Gudrun Kunst ◽  
Caetano Nigro Neto ◽  
José de Ribamar Costa Júnior ◽  
Carlos Gustavo Santos Silva ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Controlled Trial ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Volatile Anesthetic ◽  
Serum Levels ◽  
Randomized Controlled

Abstract Background Recent experimental evidence shows that sevoflurane can reduce the inflammatory response during cardiac surgery with cardiopulmonary bypass. However, this observation so far has not been assessed in an adequately powered randomized controlled trial. Methods We plan to include one hundred patients undergoing elective coronary artery bypass graft with cardiopulmonary bypass who will be randomized to receive either volatile anesthetics during cardiopulmonary bypass or total intravenous anesthesia. The primary endpoint of the study is to assess the inflammatory response during cardiopulmonary bypass by measuring PMN-elastase serum levels. Secondary endpoints include serum levels of other pro-inflammatory markers (IL-1β, IL-6, IL-8, TNFα), anti-inflammatory cytokines (TGFβ and IL-10), and microRNA expression in peripheral blood to achieve possible epigenetic mechanisms in this process. In addition clinical endpoints such as presence of major complications in the postoperative period and length of hospital and intensive care unit stay will be assessed. Discussion The trial may determine whether adding volatile anesthetic during cardiopulmonary bypass will attenuate the inflammatory response. Trial registration ClinicalTrials.gov NCT02672345. Registered on February 2016 and updated on June 2020.

Microarray analysis reveals a local inflammatory response induced by cardiopulmonary bypass in rat kidney

2011 ◽  
Vol 28 ◽  
pp. 66
Author(s):  
H. R. Bouma ◽  
I. V. Samarska ◽  
M. M.R.F. Struys ◽  
R. H. Henning ◽  
A. H. Epema
Keyword(s):  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Microarray Analysis ◽  
Rat Kidney ◽  
Local Inflammatory Response

Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model

2010 ◽  
Vol 10 (2) ◽  
pp. 252-258 ◽  
Author(s):  
Ya-juan Wang ◽  
Ya-li Jiang ◽  
Hui-fang Tang ◽  
Chun-zhen Zhao ◽  
Ji-qiang Chen
Keyword(s):  
Inflammatory Response ◽  
Rat Model ◽  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitor
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