Extracorporeal life support during and after bilateral sequential lung transplantation in patients with pulmonary artery hypertension

2020 ◽  
Vol 44 (6) ◽  
pp. 628-637 ◽  
Author(s):  
Andrea Dell’Amore ◽  
Alessio Campisi ◽  
Stefano Congiu ◽  
Sara Mazzarra ◽  
Saverio Pastore ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Lung Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Pulmonary Artery Hypertension

scholarly journals The role of extracorporeal life support in the management with severe idiopathic pulmonary artery hypertension undergoing lung transplantation: are those patients referred too late?

2019 ◽  
Vol 11 (S6) ◽  
pp. S929-S937
Author(s):  
Anton Sabashnikov ◽  
Prashant N. Mohite ◽  
Mohamed Zeriouh ◽  
Bartlomiej Zych ◽  
Diana García-Sáez ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Lung Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Pulmonary Artery Hypertension

Modified Pulmonary Artery to Left Atrium Bypass as Bridge to Lung Transplantation in Pulmonary Artery Hypertension

2015 ◽  
Vol 63 (S 01) ◽  
Author(s):  
N. Patil ◽  
A. Weymann ◽  
A. Sabashnikov ◽  
A.-F. Popov ◽  
A. Simon
Keyword(s):  
Pulmonary Artery ◽  
Lung Transplantation ◽  
Left Atrium ◽  
Pulmonary Artery Hypertension

Lung transplantation in pulmonary arterial hypertension

ESC CardioMed ◽  
2018 ◽  
pp. 2520-2524
Author(s):  
Laurent Savale
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Lung Transplantation ◽  
Medical Management ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Right Heart Failure ◽  
Optimal Timing ◽  
Optimal Medical Management ◽  
Pulmonary Arterial

Despite recent advances in medical management, lung and heart–lung transplantation remains an established treatment option in patients with end-stage pulmonary arterial hypertension (PAH) despite optimal medical therapy. The optimal timing of referral and listing patients for transplantation must take into consideration the co-morbidities, the aetiology of PAH, and the regular risk assessment based on a multidimensional approach. With the exception of PAH due to complex congenital heart disease, double-lung transplantation is the preferred option over combined heart–lung transplantation as cardiac function recovers after transplantation in most cases. The use of extracorporeal life support as a bridge to urgent transplantation may be considered in expert centres in selected patients with refractory right heart failure despite optimal medical management in an intensive care unit. With a survival rate at 5 years varying from 50% to 75%, transplantation in PAH can be considered as a life-saving procedure for patients with severe symptoms.

scholarly journals Twenty-year experience with extracorporeal life support as bridge to lung transplantation

2019 ◽  
Vol 157 (6) ◽  
pp. 2515-2525.e10 ◽  
Author(s):  
Alberto Benazzo ◽  
Stefan Schwarz ◽  
Florian Frommlet ◽  
Thomas Schweiger ◽  
Peter Jaksch ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support

scholarly journals WS8.3 Extracorporeal life support as a bridge to lung transplantation: outcome in cystic fibrosis recipients

2014 ◽  
Vol 13 ◽  
pp. S17
Author(s):  
I. Inci ◽  
U. Bürgi ◽  
C. Benden ◽  
L.C. Huber ◽  
P. Kestenholz ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support

Extracorporeal Life Support as a Bridge to Lung Transplantation: A Single-Center Experience With an Emphasis on Health-Related Quality of Life

2017 ◽  
Vol 62 (5) ◽  
pp. 588-594 ◽  
Author(s):  
Annemieke Oude Lansink-Hartgring ◽  
Wim van der Bij ◽  
Erik A Verschuuren ◽  
Michiel E Erasmus ◽  
Adrianus J de Vries ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Transplantation ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Health Related Quality ◽  
Single Center ◽  
Single Center Experience ◽  
Related Quality ◽  
Health Related

scholarly journals Trans-Aortic or Pulmonary Artery-Based Drainage for Left Ventricular Unloading and Veno-Arterial Extracorporeal Life Support Management in a Porcine Cardiogenic Shock Model.

2020 ◽  
Author(s):  
Paolo Meani ◽  
Mikulas Mlcek ◽  
Mariusz Kowalewski ◽  
Giuseppe Maria Raffa ◽  
Federica Jiritano ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Cardiogenic Shock ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Blood Stasis ◽  
Left Ventricular ◽  
Circulatory Support ◽  
Stroke Work ◽  
Organ Perfusion ◽  
Suction Device

Abstract Background The use of peripheral veno-arterial extracorporeal life support (V-A ECLS) as a mechanical circulatory support in cardiogenic shock has increased dramatically over the last years. However, increased afterload may jeopardize left ventricle (LV) recovery and cause blood stasis and pulmonary edema. Therefore, several LV unloading techniques have been developed and used with limited understanding of the actual difference among them. The aim of the present study was to compare a trans-aortic suction device (Impella) and pulmonary artery (PA) drainage, for LV unloading and V-A ECLS management as well as efficacy in a porcine cardiogenic shock (CS) model Methods A dedicated CS model compared included twelve female swine (21± 1,8-weeks old and weighing 54,3 ± 4,6 kg) supported with V-A ECLS and randomized to Impella or PA-related LV drainage. LV unloading and end-organ perfusion were evaluated through the pulmonary artery catheter and the LV pressure/volume analysis. All the variables were collected at baseline, profound CS, V-A ECLS support with maximum flow and when Impella or PA cannula run on top. Results CS was successfully induced in all twelve animals. Impella resulted in a marked drop of LVEDV compared to a slight decrease in the PA cannula group, resulting in an overall stroke work (SW) and Pressure-Volume Area (PVA) reductions with both techniques. However, SW reduction was significant in the Impella CP group (VA ECMO 3998.82027.6 mmHg x mL vs VAECMO + Impella 1796.9±1033.9 mmHg x ml, p value 0,016), leading to a more consistent PVA reduction (Impella reduction 34,7% vs PA cannula reduction 9,7%) In terms of end organ perfusion, central and mixed O 2 saturation improved with V-A ECLS, and subsequently, remaining unchanged with either Impella or PA cannula as unloading strategy Conclusions Trans-aortic suction and PA drainage provided effective LV unloading during V-A ECLS while maintaining adequate end-organ perfusion. Trans-aortic suction device provides a greater LV unloading effect and reduces more effectively the total LV stroke work.

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