Standard corneal collagen crosslinking versus transepithelial iontophoresis‐assisted corneal crosslinking, 24 months follow‐up: randomized control trial

Purpose. To study morphological changes in the cornea by confocal microscopy of simultaneous MyoRing implantation with corneal crosslinking in patients with keratoconus. Material and methods. The clinical study included 15 patients (16 eyes) with progressive keratoconus. All patients underwent a combination treatment: implantation of MyoRing intrastromal corneal rings (Dioptex GmBH, Linz, Austria) in combination with corneal crosslinking. The number of cells and quality indicators in each layer of the cornea were compared before and during 36 months after surgery. Results. Qualitative analysis of the cornea showed transient disturbances of the subepithelial nerve plexus, an increase in the reflectivity of stromal keratocytes, and moderate fibroplasia in the middle parts of the stroma in the area of the intrastromal pocket. During the follow-up period of 12 months or more after surgery, no significant changes in the corneal ultrastructure were detected in the dynamics. There was no significant decrease in endothelial cell density in the postoperative period. Conclusion. Analysis of morphological changes confirms the safety of a combination of simultaneous implantation of the MyoRing intrastromal ring and corneal crosslinking in stage II-III keratoconus by confocal microscopy and allows dynamic observation of changes in the corneal structure during intrastromal surgery. Key words: keratoconus, confocal microscopy, intrastromal corneal rings, MyoRing, corneal crosslinking.

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Experimental and morphological reasoning for the use of corneal crosslinking during keratoplasty in small domestic animals

Veterinariya, Zootekhniya i Biotekhnologiya ◽

10.36871/vet.zoo.bio.202012002 ◽

2020 ◽

Vol 1 (12) ◽

pp. 12-21

Author(s):

N. A. Slesarenko ◽

◽

A. G. Shilkin ◽

U. E. Lukashina ◽

◽

...

Keyword(s):

Postoperative Period ◽

Clinical Observation ◽

Corneal Stroma ◽

Collagen Matrix ◽

Domestic Animals ◽

Demarcation Line ◽

Collagen Crosslinking ◽

Corneal Crosslinking ◽

Corneal Collagen Crosslinking ◽

Corneal Collagen

The article reflects the influence of corneal collagen crosslinking on changes in the morphofunctional signs of the corneal stroma. Data on changes in the anterior layers of the stroma, which are expressed by a compact packing of fibers without signs of even minimal edema, as well as a demarcation line separating the area of impact from the indifferent zone, are scientifically substantiated. Clinical observation of cats and dogs after keratoplasty using a crosslinking modified cornea showed the most favorable course of the postoperative period which was expressed in an increase in the resistance of the collagen matrix of the donor tissue to collagenases which is especially important when using large and giant transplants.

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Accelerated (9 mW/cm2) Corneal Collagen Crosslinking for Keratoconus—A 1-Year Follow-up

Cornea ◽

10.1097/ico.0000000000000299 ◽

2015 ◽

Vol 34 (1) ◽

pp. e1-e2 ◽

Cited By ~ 3

Author(s):

Uri Elbaz ◽

Carl Shen ◽

Alejandro Lichtinger ◽

Noa Avni Zauberman ◽

Yakov Goldich ◽

...

Keyword(s):

Collagen Crosslinking ◽

Corneal Collagen Crosslinking ◽

Corneal Collagen

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Comparative Results Between “Epi-Off” Accelerated and “Epi-Off” Standard Corneal Collagen Crosslinking-UVA in Progressive Keratoconus – 7 Years of Follow-Up

Therapeutics and Clinical Risk Management ◽

10.2147/tcrm.s321410 ◽

2021 ◽

Vol Volume 17 ◽

pp. 975-988

Author(s):

Cristina Ariadna Nicula ◽

Anca Maria Rednik ◽

Ariadna Patricia Nicula ◽

Adriana Elena Bulboaca ◽

Dorin Nicula ◽

...

Keyword(s):

Collagen Crosslinking ◽

Corneal Collagen Crosslinking ◽

Comparative Results ◽

Corneal Collagen

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Silicone Hydrogel Miniscleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia

International Journal of Keratoconus and Ectatic Corneal Diseases ◽

10.5005/jp-journals-10025-1092 ◽

2014 ◽

Vol 3 (3) ◽

pp. 127-129

Author(s):

Boris Severinsky

Keyword(s):

Contact Lens ◽

Contact Lenses ◽

Visual Outcome ◽

Visual Rehabilitation ◽

Collagen Crosslinking ◽

Silicone Hydrogel ◽

Corneal Collagen Crosslinking ◽

Corneal Collagen

ABSTRACT Purpose To report successful visual rehabilitation of post refractive surgery keratoectasia shortly after corneal collage crosslinking (CXL) procedure achieved with silicone hydrogel mini-scleral (SHmS) contact lens. Materials and methods A 29-year-old woman attended to our clinic with complaints on decreased vision in her left eye. Twelve years earlier she underwent bilateral laser-assisted in situ keratomileusis (LASIK) procedure for myopia correction. Corneal topography revealed bilateral central keratoectasia with maximal keratometry values of 55.4 Diopter (D) for her right eye and 59.7 D for the left, corneal thicknesses were 422 and 443 respectively. The patient underwent an uneventful CXL procedure in her left eye and was fitted with SHmS lens 5 weeks later. The lens was designed to rest over the patients’ sclera and perilimbal cornea and vault the central cornea with minimal support over it. Results SHmS lens fitting resulted in significant subjective improvement in visual acuity (from 20/200, unaided to 20/25, contact lens corrected). The patient was able to wear the lens upto 10 hours a day with stable contact lens corrected vision. No contact lens related complications, such as edema or neovascularization were observed during 3 months follow-up period. As a result of successful restoration of vision in the CXL-treated eye, the patient was scheduled for the procedure in her other eye. Conclusion SHmS contact lens should be considered as an option for the visual rehabilitation of corneas shortly after collagen corneal crosslinking procedure. This novel contact lens modality made from flexible and highly gas permeable material minimizes contact lens influence on corneal recovery after CXL and provides an excellent visual outcome. How to cite this article Severinsky B. Silicone Hydrogel Mini-scleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia. Int J Kerat Ect Cor Dis 2014;3(3):127-129.

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Long-term results of corneal collagen crosslinking with ectatic forms of corneal dystrophy

Ophthalmology journal ◽

10.17816/ov18510 ◽

2020 ◽

Vol 12 (4) ◽

pp. 29-34 ◽

Cited By ~ 1

Author(s):

Oleg A. Frolov ◽

Sergey Yu. Astakhov ◽

Sergey A. Novikov ◽

Sergey A. Novikov

Keyword(s):

Corneal Dystrophy ◽

Treatment Method ◽

Long Term Results ◽

Corneal Surface ◽

Collagen Crosslinking ◽

Corneal Ectasia ◽

Corneal Collagen Crosslinking ◽

Corneal Collagen

Corneal collagen crosslinking is one of the most effective methods of prophylactics and treatment of progressive corneal ectasias. In the literature, there are occasional data related to remote results concerning only the most common form of ectasias keratoconus. In published studies, no remote results are met concerning the efficacy of corneal collagen crosslinking in other forms of corneal ectasias, which are now on the rise, including secondary ectasias that became more frequent with refractive surgery. The number of diagnosed cases of pellucid marginal degeneration increased as well. The literature shows no data on comparative analysis of remote results concerning the efficacy of this method in treatment of various forms of corneal ectasias. The aim of the investigation was to evaluate the efficacy of corneal collagen crosslinking based on the analysis of long-term results of this treatment method for various forms of corneal ectasias. Materials and methods. The results of corneal collagen crosslinking in patients with various forms of corneal ectasia 6 years after surgery were analyzed. The nosological structure of the study included patients with keratoconus, pellucid marginal degeneration, and secondary ectasia. The group of patients with keratoconus included 30 patients (30 eyes), that with pellucid marginal degeneration 30 patients (30 eyes), and that with secondary ectasia 30 patients (30 eyes). Corneal collagen crosslinking was performed by the same specialist, during the first or the second year of follow-up. Then changes in the state of the cornea and visual functions were monitored for 6 years. To assess the efficacy, preoperative examination results and interim data were used. Results. In all groups, there was an increase in the best corrected visual acuity, a decrease in the index of asymmetry of the corneal surface and its refractive power in the center of ectasia. However, best corneal collagen crosslinking results were obtained in groups of patients with keratoconus and secondary corneal ectasia.

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