Experimental and morphological reasoning for the use of corneal crosslinking during keratoplasty in small domestic animals

2020 ◽  
Vol 1 (12) ◽  
pp. 12-21
Author(s):  
N. A. Slesarenko ◽  
◽  
A. G. Shilkin ◽  
U. E. Lukashina ◽  
◽  
...  
Keyword(s):  
Postoperative Period ◽  
Clinical Observation ◽  
Corneal Stroma ◽  
Collagen Matrix ◽  
Domestic Animals ◽  
Demarcation Line ◽  
Collagen Crosslinking ◽  
Corneal Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

The article reflects the influence of corneal collagen crosslinking on changes in the morphofunctional signs of the corneal stroma. Data on changes in the anterior layers of the stroma, which are expressed by a compact packing of fibers without signs of even minimal edema, as well as a demarcation line separating the area of impact from the indifferent zone, are scientifically substantiated. Clinical observation of cats and dogs after keratoplasty using a crosslinking modified cornea showed the most favorable course of the postoperative period which was expressed in an increase in the resistance of the collagen matrix of the donor tissue to collagenases which is especially important when using large and giant transplants.

scholarly journals Corneal Crosslinking in Progressive Keratoconus: Comparison of Dextran-Based and Hydroxypropyl Methylcellulose-Based Riboflavin Solutions Differences in demarcation line depth and 1 yaear outcomes

2019 ◽  
Vol 70 (4) ◽  
pp. 1152-1156
Author(s):  
Miruna Gabriela Burcel ◽  
Catalina Corbu ◽  
Valeria Coviltir ◽  
Vasile Potop ◽  
Mihaela Constantin ◽  
...  
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Anterior Segment ◽  
Demarcation Line ◽  
Collagen Crosslinking ◽  
Corneal Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Myopic Astigmatism ◽  
Line Depth ◽  
Corneal Collagen ◽  
Corneal Thinning

Keratoconus is a progressive ectatic disorder characterised by irregular myopic astigmatism and loss of visual acuity due to corneal thinning. Corneal collagen crosslinking is the treatment recognised to stop the progression of keratoconus. Our study evaluates and compares visibility and depth of the stromal demarcation line after corneal collagen crosslinking using anterior segment optical coherence tomography between two groups:crosslinking with dextran-based and hydroxypropyl methylcellulose-based riboflavin solutions. Our work proved a better visibility and a deeper demarcation line when we used HPMC-based riboflavin. Also the study revealed that HPMC-based riboflavin is associated with better biomechanical outcomes than dextran-based riboflavin.

scholarly journals Anterior and posterior corneal stroma elasticity after corneal collagen crosslinking treatment

2013 ◽  
Vol 116 ◽  
pp. 58-62 ◽  
Author(s):  
Janice Dias ◽  
Vasilios F. Diakonis ◽  
Vardhaman P. Kankariya ◽  
Sonia H. Yoo ◽  
Noël M. Ziebarth
Keyword(s):  
Corneal Stroma ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

Corneal Densitometry Changes after Epithelium-Off Corneal Collagen Crosslinking

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Karim N Abbas ◽  
Raafat A. El Sayed ◽  
Mouamen M Mostafa
Keyword(s):  
Prospective Observational Study ◽  
Corneal Stroma ◽  
Collagen Matrix ◽  
Significant Elevation ◽  
The Past ◽  
Corneal Densitometry ◽  
Post Surgery ◽  
Corneal Collagen Crosslinking ◽  
Stromal Layer ◽  
Corneal Collagen

Abstract Background Keratoconus is a progressive non-inflammatory, degenerative disease that affects the integrity of the collagen matrix within the corneal stroma. Corneal cross-linking (CXL) has been described as the only modality in halting the disease progression over the past decade. Aim of the Work To compare the change in corneal densitometry before and 6 months after CXL using our unique protocol. Patients and Methods A prospective observational study was conducted on 30 eyes of 30 patients with progressive keratoconus. Epitheliumoff CXL was done with application of Riboflavin (VibeX RapidTM) for 6 minutes at a rate of 1 drop/ minute. UVA was delivered using the Avedro KXL machine (Avedro, Waltham, MA, USA) using the following parameters: 7.2 joules, 12 milli watt/ minute and 10 minutes of accelerated continuous UV delivery. Results Within the anterior (120 um) stromal layer, the concentric zones (0 to 2 mm) and (2 to 6 mm) showed a significant elevation of mean densitometry 6 months post-surgery (P = 0.020) and (P = 0.023) respectively compared to the baseline, However the concentric zones (6 to 10 mm) and (10 to 12 mm) showed a non-significant elevation of mean densitometry 6 months post-surgery (P = 0.167) and (P = 0.234) respectively compared to the baseline. Conclusion There is a significant increase in corneal densitometry 6 months postsurgery of the anterior stromal layer within the central 6 mm zone.

scholarly journals MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus

2020 ◽  
Author(s):  
Mehrdad Mohammadpour ◽  
Ahmad Masoumi ◽  
Mahmoud Dehghan ◽  
Mohammad Nasser Hashemian ◽  
Shahab Addin Karami ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Corneal Stroma ◽  
Safety And Efficacy ◽  
Collagen Crosslinking ◽  
Randomized Controlled ◽  
Uncorrected Distance Visual Acuity ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose: To evaluate the safety and efficacy of femtosecond laser-assisted MyoRing implantation with concurrent corneal collagen crosslinking (CXL) compared to MyoRing alone for the treatment of progressive keratoconus. Methods: A total of 60 patients were enrolled in this randomized controlled trial. The patients were randomly allocated into two groups. In the first group, MyoRing was implanted, while in the second, it was inserted in the corneal stroma using the same technique, along with simultaneous CXL. Visual, refractive, topographic, and abberometric outcomes were measured preoperatively and at every postoperative visit. Results: Data of 47 patients were available at the end of the study; 28 in the MyoRing group and 19 in the MyoRing + CXL group. The mean uncorrected distance visual acuity (UDVA) improved from 0.79 ± 0.39 logMAR to 0.52 ± 0.31 logMAR (P < 0.05) in the MyoRing + CXL group and from 0.65 ± 0.38 logMAR to 0.62 ± 0.23 logMAR (P = 0.70) in the MyoRing group. CDVA changed from 0.33 ± 0.19 logMAR to 0.25 ± 0.16 logMAR (P = 0.10) in the MyoRing + CXL group and 0.32 ± 0.22 logMAR to 0.33 ± 0.17 logMAR (P > 0.5) in the MyoRing group. The mean keratometry (Km) decreased from 47.5 ± 2.7 D to 43.8 ± 3.2 D (P < 0.001) in the MyoRing group and 49.3 ± 3.4 D to 45.1 ± 3.0 D (P < 0.001) in the MyoRing + CXL group. Besides, horizontal coma was significantly lower in the MyoRing + CXL group (P = 0.022). Conclusion: MyoRing insertion combined with CXL is a safe and effective method for the treatment of keratoconus. The visual and topographic outcomes were comparable to that for MyoRing insertion after 10 months; however, horizontal coma was significantly lower in the MyoRing + CXL group.

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