Therapeutic Effect of Corneal Crosslinking on Fungal Keratitis: Efficacy of Corneal Collagen Crosslinking as an Adjuvant Therapy for Fungal Keratitis in a Tertiary Eye Hospital in South India

2020 ◽  
pp. 1-8
Author(s):  
Vimalin Jeyalatha Mani ◽  
Durgadevi Parthasarathy ◽  
Prema Padmanabhan ◽  
Niveditha Narayanan ◽  
Meena Lakshmipathy ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Therapeutic Effect ◽  
South India ◽  
Fungal Keratitis ◽  
Collagen Crosslinking ◽  
Corneal Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

Experimental and morphological reasoning for the use of corneal crosslinking during keratoplasty in small domestic animals

2020 ◽  
Vol 1 (12) ◽  
pp. 12-21
Author(s):  
N. A. Slesarenko ◽  
◽  
A. G. Shilkin ◽  
U. E. Lukashina ◽  
◽  
...  
Keyword(s):  
Postoperative Period ◽  
Clinical Observation ◽  
Corneal Stroma ◽  
Collagen Matrix ◽  
Domestic Animals ◽  
Demarcation Line ◽  
Collagen Crosslinking ◽  
Corneal Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

The article reflects the influence of corneal collagen crosslinking on changes in the morphofunctional signs of the corneal stroma. Data on changes in the anterior layers of the stroma, which are expressed by a compact packing of fibers without signs of even minimal edema, as well as a demarcation line separating the area of impact from the indifferent zone, are scientifically substantiated. Clinical observation of cats and dogs after keratoplasty using a crosslinking modified cornea showed the most favorable course of the postoperative period which was expressed in an increase in the resistance of the collagen matrix of the donor tissue to collagenases which is especially important when using large and giant transplants.

scholarly journals Corneal Crosslinking in Progressive Keratoconus: Comparison of Dextran-Based and Hydroxypropyl Methylcellulose-Based Riboflavin Solutions Differences in demarcation line depth and 1 yaear outcomes

2019 ◽  
Vol 70 (4) ◽  
pp. 1152-1156
Author(s):  
Miruna Gabriela Burcel ◽  
Catalina Corbu ◽  
Valeria Coviltir ◽  
Vasile Potop ◽  
Mihaela Constantin ◽  
...  
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Anterior Segment ◽  
Demarcation Line ◽  
Collagen Crosslinking ◽  
Corneal Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Myopic Astigmatism ◽  
Line Depth ◽  
Corneal Collagen ◽  
Corneal Thinning

Keratoconus is a progressive ectatic disorder characterised by irregular myopic astigmatism and loss of visual acuity due to corneal thinning. Corneal collagen crosslinking is the treatment recognised to stop the progression of keratoconus. Our study evaluates and compares visibility and depth of the stromal demarcation line after corneal collagen crosslinking using anterior segment optical coherence tomography between two groups:crosslinking with dextran-based and hydroxypropyl methylcellulose-based riboflavin solutions. Our work proved a better visibility and a deeper demarcation line when we used HPMC-based riboflavin. Also the study revealed that HPMC-based riboflavin is associated with better biomechanical outcomes than dextran-based riboflavin.

scholarly journals Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Deepa Viswanathan ◽  
Nikhil L. Kumar ◽  
John J. Males
Keyword(s):  
Young Patients ◽  
Ultraviolet A ◽  
Effective Treatment Option ◽  
Collagen Crosslinking ◽  
Paediatric Patients ◽  
Corneal Grafting ◽  
Minimum Angle ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.Methods. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min).Results. The mean patient age was 14.3 ± 2.4 years (range 8–17) and mean followup duration was 20.1 ± 14.25 months (range 6–48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D (P=0.03) and 49.34 D (P=0.005), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (P=0.89) and topometric astigmatism reduced from mean 3.50 D to 3.25 D (P=0.51).Conclusions. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.

scholarly journals Intrastromal corneal rings and corneal collagen crosslinking for progressive keratoconus: comparison of two sequences

Eye ◽  
2014 ◽  
Vol 29 (2) ◽  
pp. 294-295 ◽  
Author(s):  
N Saib ◽  
S Bonnel ◽  
J-R Fenolland ◽  
M Abrieu ◽  
C Rambaud ◽  
...  
Keyword(s):  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

Evaluation of changes in corneal biomechanics in eyes with keratectasia

2021 ◽  
pp. 179-187
Author(s):  
B.E. Malugin ◽  
◽  
E.G. Solodkova ◽  
S.V. Balalin ◽  
V.S. Kulikov ◽  
...  
Keyword(s):  
Corneal Thickness ◽  
Corneal Biomechanics ◽  
Corvis St ◽  
Collagen Crosslinking ◽  
The Third ◽  
Corneal Rigidity ◽  
Corneal Collagen Crosslinking ◽  
Early Features ◽  
Healthy Persons ◽  
Corneal Collagen

Purpose. To make a comparative analysis of topographic, tomographic and biomechanical values, measured by Pentacam HR and Corvis ST, in healthy multirefractive cohort versus patients with keratectasia of various severity. Material and methods. The prospective study comprised 237 patients aged from 18 to 47 years, subdivided into three groups. The first group included 174 healthy persons with various refraction (174 eyes). The second and the third group embraced 63 patients with keratoconus: 36 patients (36 eyes) with keratoconus of the I degree and 27 eyes with keratoconus of the II and III degrees. Besides the conventional comprehensive ocular examination the following studies were performed in all the patients: evaluation of topographic, tomographic and biomechanical corneal properties with application of Pentacam HR and Corvis ST (OCULUS Optikgerate GmbH; Wetzlar, Germany). Results. It was revealed that the following biomechanical values, assessed by means of Pentacam HR and Corvis ST, exhibited statistically significant changes (p<0,001) in all degrees of ketatoconus: a relative corneal thickness by Ambrosio, inverted radius of applanation curvature (IntRadius), DA Ratio Coefficient, values of corneal rigidity – SP-A 1 and SSI. Conclusion. The detected parameters may be applied as indicators, allowing to evaluate corneal biomechanics, to define early features of ectatic process, to assess effectiveness of the performed corneal collagen crosslinking and intralamellar keratoplasty with implantation of corneal segments. Key words: keratoconus, corneal biomechanics, pachymetry, index of pachymetric progression, corneal viscoelasticity.

scholarly journals Combined small-incision lenticule extraction and intrastromal corneal collagen crosslinking to treat mild keratoconus: Long-term follow-up

2015 ◽  
Vol 41 (11) ◽  
pp. 2524-2532 ◽  
Author(s):  
Enrique O. Graue-Hernandez ◽  
Gabriela L. Pagano ◽  
Guillermo Garcia-De la Rosa ◽  
Arturo Ramirez-Miranda ◽  
Jesus Cabral-Macias ◽  
...  
Keyword(s):  
Small Incision Lenticule Extraction ◽  
Collagen Crosslinking ◽  
Small Incision ◽  
Long Term Follow Up ◽  
Lenticule Extraction ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen
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