Bilateral activation of retinal microglia: quantitative analysis of the area the retina occupied by IBA‐1 +  cells in the nerve fiber layer‐ganglion cell layer at different time points after laser‐induced ocular hypertension in mice

The objectives of the present study are to determine the effects of alcohol use on the retinal nerve fiber layer (RNFL) thickness and macular thickness of abstinent patients with alcohol use disorders (AUD) and to assess whether it correlates with alcohol consumption and/or cognitive impairment. This was a prospective, observational study that included 21 patients (42 eyes) and 21 controls (42 eyes). Patients met the criteria for early remission AUD at the moment of inclusion. We used optical coherence tomography to assess retinal thickness. Macular thickness in the group of AUD patients was lower in all quadrants (p < 0.05), with the exception of the peripheral and central. Regarding the nerve fiber layer in the macular and papilla areas, we found no significant differences. At the retina ganglion cell layer and in the nerve fiber of the macula, we found significant differences in all quadrants (p < 0.05), with the exception of the superior and superior nasal area, for the right eye. For the left eye, the only differences were found in the lower quadrant. Finally, when comparing the AUD patients to the controls, we found significant reductions in the ganglion cell layer of the macula in all quadrants in the former. There was a significant correlation between these findings and cognitive impairment (measured with the Test de Detección de Deterioro Cognitivo en Alcoholismo (TEDCA)), but not with alcohol consumption. Alcohol consumption is correlated with retinal harm and related cognitive decline.

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Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer

Journal of Neuro-Ophthalmology ◽

10.1097/wno.0000000000000422 ◽

2016 ◽

Vol 36 (4) ◽

pp. 417-438 ◽

Cited By ~ 21

Author(s):

John J. Chen ◽

Randy H. Kardon

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Ganglion Cell ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Ganglion Cell Layer ◽

Cell Layer ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Tomography Analysis

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Retinal Ganglion Cell Layer Thinning Followed By Retinal Nerve Fiber Layer Thinning In Patients with Uveitis

Journal of Clinical & Experimental Immunology ◽

10.33140/jcei/01/02/00005 ◽

2016 ◽

Vol 1 (2) ◽

Keyword(s):

Optic Nerve ◽

Ganglion Cell ◽

Nerve Fiber ◽

Retinal Ganglion Cell ◽

Ganglion Cell Layer ◽

Cell Layer ◽

Retinal Ganglion ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Retinal Ganglion Cell Layer

In the model of experimentally induced ischemia- reperfusion injury, retinal ganglion cells (RGC) expressing the gene AP-1 result apoptosis. The inflammation mediators, such as TNF-α, IL-1β, etc. lead RGC to apoptosis, that may lead the thinning of the retinal ganglion cell layer (RGCL) followed by the optic nerve fiber layer (RNFL) thinning. In his study we observed retinal ganglion cell and optic nerve fiber layer thinning in patients with various uveitis, that the pathological features appear obliterative vasculitis, using the optical coherence tomography (OCT) imaging analyses. Subjects were 182 eyes of 91 uveitis patients without glaucoma. Comparison were patients with normal tension glaucoma (NTG). Image analyses were conducted with 3D OCT-2000. As a result average RGCL thickness values in the patients with uveitis were significantly(p<0.01) thinner than those in healthies. Cycle scan findings of RNFL around the optic disc in the patients with uveitis showed significant thinning especially at nasal side. The retinal ganglion cell layer thinning followed by the retinal nerve fiber thinning in the patients with various uveitis was observed, and the thinning was similar to that in patients with glaucoma. The observation of RGCL and RNFL thickness may be useful for the diagnosis and the follow-up of uveitis.

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