ID2 controls differentiation of enteroendocrine cells in mouse small intestine

2022 ◽  
Author(s):  
Valeriya V Zinina ◽  
Frank Ruehle ◽  
Patricia Winkler ◽  
Lisa Rebmann ◽  
Hanna Lukas ◽  
...  
Keyword(s):  
Small Intestine ◽  
Enteroendocrine Cells ◽  
Mouse Small Intestine

scholarly journals Enteroendocrine Cells Are Specifically Marked by Cell Surface Expression of Claudin-4 in Mouse Small Intestine

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90638 ◽  
Author(s):  
Takahiro Nagatake ◽  
Harumi Fujita ◽  
Nagahiro Minato ◽  
Yoko Hamazaki
Keyword(s):  
Small Intestine ◽  
Cell Surface ◽  
Surface Expression ◽  
Enteroendocrine Cells ◽  
Cell Surface Expression ◽  
Mouse Small Intestine

Phenotypic characterization of taste cells of the mouse small intestine

2007 ◽  
Vol 292 (5) ◽  
pp. G1420-G1428 ◽  
Author(s):  
Kate Sutherland ◽  
Richard L. Young ◽  
Nicole J. Cooper ◽  
Michael Horowitz ◽  
L. Ashley Blackshaw
Keyword(s):  
Nitric Oxide ◽  
Small Intestine ◽  
Nitric Oxide Synthase ◽  
Epithelial Cells ◽  
Neuronal Nitric Oxide Synthase ◽  
Enteroendocrine Cells ◽  
Brush Cells ◽  
Cell Markers ◽  
Mouse Small Intestine ◽  
Oxide Synthase

Nutrient-evoked gastrointestinal reflexes are likely initiated by specialized epithelial cells located in the small intestine that detect luminal stimuli and release mediators that activate vagal endings. The G-protein α-gustducin, a key signal molecule in lingual taste detection, has been identified in mouse small intestine, where it may also subserve nutrient detection; however, the phenotype of α-gustducin cells is unknown. Immunohistochemistry was performed throughout the mouse small intestine for α-gustducin, enteroendocrine cell markers 5-HT and glucagon-like peptide-1 (GLP-1), and brush cell markers neuronal nitric oxide synthase and Ulex europaeus agglutinin-1 (UEA-1) lectin binding, singly, and in combination. α-Gustducin was expressed in solitary epithelial cells of the mid to upper villus, which were distributed in a regional manner with most occurring within the midjejunum. Here, 27% of α-gustducin cells colabeled for 5-HT and 15% for GLP-1; 57% of α-gustducin cells colabeled UEA-1, with no triple labeling. α-Gustducin cells that colabeled for 5-HT or GLP-1 were of distinct morphology and exhibited a different α-gustducin immunolabeling pattern to those colabeled with UEA-1. Neuronal nitric oxide synthase was absent from intestinal epithelium despite strong labeling in the myenteric plexus. We conclude that subsets of enteroendocrine cells in the midjejunum and brush cells (more generally distributed) are equipped to utilize α-gustducin signaling in mice. Intestinal taste modalities may be signaled by these enteroendocrine cells via the release of 5-HT, GLP-1, or coexpressed mediators or by brush cells via a nonnitrergic mediator in distinct regions of the intestine.

scholarly journals In Vivo Imaging of Enteric Neurogenesis in the Deep Tissue of Mouse Small Intestine

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e54814 ◽  
Author(s):  
Kei Goto ◽  
Go Kato ◽  
Isao Kawahara ◽  
Yi Luo ◽  
Koji Obata ◽  
...  
Keyword(s):  
Small Intestine ◽  
In Vivo Imaging ◽  
Deep Tissue ◽  
Mouse Small Intestine

scholarly journals Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine

2018 ◽  
Vol 30 (9) ◽  
pp. e13429
Author(s):  
F. Bianco ◽  
S. T. Eisenman ◽  
M. G. Colmenares Aguilar ◽  
E. Bonora ◽  
P. Clavenzani ◽  
...  
Keyword(s):  
Small Intestine ◽  
Myenteric Neurons ◽  
Mouse Small Intestine ◽  
Human And Mouse
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