scholarly journals Comparison of immune response between Escherichia coli ‐derived recombinant subunit vaccine and formol‐inactivated whole particle vaccine against viral haemorrhagic septicaemia virus (VHSV) in rainbow trout

2021 ◽  
Author(s):  
Cuneyt Tamer ◽  
Harun Albayrak ◽  
Semra Gumusova
Keyword(s):  
Escherichia Coli ◽  
Immune Response ◽  
Rainbow Trout ◽  
Subunit Vaccine ◽  
Haemorrhagic Septicaemia ◽  
Recombinant Subunit Vaccine ◽  
Viral Haemorrhagic Septicaemia Virus

Functional nutrition modulates the early immune response against viral haemorrhagic septicaemia virus (VHSV) in rainbow trout

2019 ◽  
Vol 94 ◽  
pp. 769-779 ◽  
Author(s):  
Esther Leal ◽  
María Camino Ordás ◽  
Irene Soleto ◽  
Carlos Zarza ◽  
Charles McGurk ◽  
...  
Keyword(s):  
Immune Response ◽  
Rainbow Trout ◽  
Haemorrhagic Septicaemia ◽  
Early Immune Response ◽  
Viral Haemorrhagic Septicaemia Virus

scholarly journals Protection against Lethal Leptospirosis after Vaccination with LipL32 Coupled or Coadministered with the B Subunit of Escherichia coli Heat-Labile Enterotoxin

2012 ◽  
Vol 19 (5) ◽  
pp. 740-745 ◽  
Author(s):  
André A. Grassmann ◽  
Samuel R. Félix ◽  
Carolina Ximendes dos Santos ◽  
Marta G. Amaral ◽  
Amilton C. P. Seixas Neto ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Immune Response ◽  
Subunit Vaccine ◽  
Lethal Dose ◽  
Control Group ◽  
Hamster Model ◽  
Content Type ◽  
B Subunit ◽  
Heat Labile ◽  
A Subunit

ABSTRACTLeptospirosis, a worldwide zoonosis, lacks an effective, safe, and cross-protective vaccine. LipL32, the most abundant, immunogenic, and conserved surface lipoprotein present in all pathogenic species ofLeptospira, is a promising antigen candidate for a recombinant vaccine. However, several studies have reported a lack of protection when this protein is used as a subunit vaccine. In an attempt to enhance the immune response, we used LipL32 coupled to or coadministered with the B subunit of theEscherichia coliheat-labile enterotoxin (LTB) in a hamster model of leptospirosis. After homologous challenge with 5× the 50% lethal dose (LD50) ofLeptospira interrogans, animals vaccinated with LipL32 coadministered with LTB and LTB::LipL32 had significantly higher survival rates (P< 0.05) than animals from the control group. This is the first report of a protective immune response afforded by a subunit vaccine using LipL32 and represents an important contribution toward the development of improved leptospirosis vaccines.

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