The Hendra virus vaccine: perceptions regarding the role of antibody titre testing

2021 ◽  
Author(s):  
RS Barrett ◽  
A Wiethoelter ◽  
K Halpin
Keyword(s):  
Antibody Titre ◽  
Virus Vaccine ◽  
Hendra Virus

scholarly journals Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children

2008 ◽  
Vol 15 (7) ◽  
pp. 1042-1053 ◽  
Author(s):  
Bruce D. Forrest ◽  
Michael W. Pride ◽  
Andrew J. Dunning ◽  
Maria Rosario Z. Capeding ◽  
Tawee Chotpitayasunondh ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Young Children ◽  
Immune Responses ◽  
Virus Vaccine ◽  
Elispot Assay ◽  
Influenza Virus Vaccine ◽  
The Philippines ◽  
Influenza Viruses ◽  
Ifn Γ

ABSTRACT The highly sensitive gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISPOT) assay permits the investigation of the role of cell-mediated immunity (CMI) in the protection of young children against influenza. Preliminary studies of young children confirmed that the IFN-γ ELISPOT assay was a more sensitive measure of influenza memory immune responses than serum antibody and that among seronegative children aged 6 to <36 months, an intranasal dose of 107 fluorescent focus units (FFU) of a live attenuated influenza virus vaccine (CAIV-T) elicited substantial CMI responses. A commercial inactivated influenza virus vaccine elicited CMI responses only in children with some previous exposure to related influenza viruses as determined by detectable antibody levels prevaccination. The role of CMI in actual protection against community-acquired, culture-confirmed clinical influenza by CAIV-T was investigated in a large randomized, double-blind, placebo-controlled dose-ranging efficacy trial with 2,172 children aged 6 to <36 months in the Philippines and Thailand. The estimated protection curve indicated that the majority of infants and young children with ≥100 spot-forming cells/106 peripheral blood mononuclear cells were protected against clinical influenza, establishing a possible target level of CMI for future influenza vaccine development. The ELISPOT assay for IFN-γ is a sensitive and reproducible measure of CMI and memory immune responses and contributes to establishing requirements for the future development of vaccines against influenza, especially those used for children.

Response of Australian veterinarians to the announcement of a Hendra virus vaccine becoming available

2013 ◽  
Vol 91 (8) ◽  
pp. 328-331 ◽  
Author(s):  
D Mendez ◽  
P Büttner ◽  
R Speare
Keyword(s):  
Virus Vaccine ◽  
Hendra Virus

Examination of the role of histidine residues proximal to the cleavage site on cathepsin L processing of the Hendra virus fusion protein

2008 ◽  
Vol 22 (S2) ◽  
pp. 223-223
Author(s):  
Everett C Smith ◽  
Rachel M Schowalter ◽  
Rebecca Ellis Dutch
Keyword(s):  
Fusion Protein ◽  
Cleavage Site ◽  
Cathepsin L ◽  
Hendra Virus ◽  
Histidine Residues ◽  
Virus Fusion

scholarly journals Critical Role of TLR7 Signaling in the Priming of Cross-Protective Cytotoxic T Lymphocyte Responses by a Whole Inactivated Influenza Virus Vaccine

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63163 ◽  
Author(s):  
Natalija Budimir ◽  
Aalzen de Haan ◽  
Tjarko Meijerhof ◽  
Simke Waijer ◽  
Louis Boon ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Lymphocyte ◽  
Virus Vaccine ◽  
Cytotoxic T Lymphocyte ◽  
Critical Role ◽  
Influenza Virus Vaccine ◽  
Lymphocyte Responses

scholarly journals Role of N-Linked Glycosylation of the Hendra Virus Fusion Protein

2005 ◽  
Vol 79 (12) ◽  
pp. 7922-7925 ◽  
Author(s):  
James Richard Carter ◽  
Cara Theresia Pager ◽  
Stephen Derrick Fowler ◽  
Rebecca Ellis Dutch
Keyword(s):  
Protein Folding ◽  
Fusion Protein ◽  
Hendra Virus ◽  
Heptad Repeat ◽  
F Protein ◽  
Virus Fusion ◽  
Protein Mutants

ABSTRACT The Hendra virus fusion (F) protein contains five potential sites for N-linked glycosylation in the ectodomain. Examination of F protein mutants with single asparagine-to-alanine mutations indicated that two sites in the F2 subunit (N67 and N99) and two sites in the F1 subunit (N414 and N464) normally undergo N-linked glycosylation. While N-linked modification at N414 is critical for protein folding and transport, F proteins lacking carbohydrates at N67, N99, or N464 remained fusogenically active. As N464 lies within heptad repeat B, these results contrast with those seen for several paramyxovirus F proteins.

scholarly journals “Why won’t they just vaccinate?” Horse owner risk perception and uptake of the Hendra virus vaccine

2017 ◽  
Vol 13 (1) ◽  
Author(s):  
J. Manyweathers ◽  
H. Field ◽  
N. Longnecker ◽  
K. Agho ◽  
C. Smith ◽  
...  
Keyword(s):  
Risk Perception ◽  
Virus Vaccine ◽  
Hendra Virus ◽  
Horse Owner

scholarly journals Beyond Anchoring: the Expanding Role of the Hendra Virus Fusion Protein Transmembrane Domain in Protein Folding, Stability, and Function

2012 ◽  
Vol 86 (6) ◽  
pp. 3003-3013 ◽  
Author(s):  
E. C. Smith ◽  
M. R. Culler ◽  
L. M. Hellman ◽  
M. G. Fried ◽  
T. P. Creamer ◽  
...  
Keyword(s):  
Protein Folding ◽  
Fusion Protein ◽  
Transmembrane Domain ◽  
Hendra Virus ◽  
Virus Fusion ◽  
And Function

The role of T cells in protection by an inactivated infectious bursal disease virus vaccine

2002 ◽  
Vol 89 (3-4) ◽  
pp. 159-167 ◽  
Author(s):  
Silke Rautenschlein ◽  
H.-Y Yeh ◽  
J.M Sharma
Keyword(s):  
T Cells ◽  
Disease Virus ◽  
Virus Vaccine ◽  
Infectious Bursal Disease Virus ◽  
Infectious Bursal Disease ◽  
Bursal Disease
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