scholarly journals Stem cell therapy for bone repair: a systematic review and meta-analysis of preclinical studies with large animal models

2014 ◽  
Vol 78 (4) ◽  
pp. 718-726 ◽  
Author(s):  
Yun Liao ◽  
Xiao-Long Zhang ◽  
Ling Li ◽  
Fu-Ming Shen ◽  
Ming-Kang Zhong
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Bone Repair ◽  
Meta Analysis ◽  
Large Animal ◽  
Preclinical Studies ◽  
Large Animal Models

scholarly journals Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease

2011 ◽  
Vol 91 (4) ◽  
pp. 649-658 ◽  
Author(s):  
T. I. G. van der Spoel ◽  
S. J. Jansen of Lorkeers ◽  
P. Agostoni ◽  
E. van Belle ◽  
M. Gyongyosi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Heart Disease ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models

scholarly journals CLINICAL RELEVANCE OF ISCHEMIC LARGE ANIMAL MODELS IN STEM CELL THERAPY; AN OVERVIEW AND META-ANALYSIS.

2011 ◽  
Vol 57 (14) ◽  
pp. E1011
Author(s):  
Tycho Van der Spoel ◽  
Sanne Jansen of Lorkeers ◽  
Pierfrancesco Agostoni ◽  
Eric Van Belle ◽  
Joost Sluijter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Relevance ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Effect of Stem Cell Therapy on Bone Mineral Density: A Meta-Analysis of Preclinical Studies in Animal Models of Osteoporosis

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149400 ◽  
Author(s):  
Feng Li ◽  
Changlin Zhou ◽  
Liang Xu ◽  
Shuqing Tao ◽  
Jingyi Zhao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Bone Mineral ◽  
Stem Cell Therapy ◽  
Meta Analysis ◽  
Preclinical Studies ◽  
Mineral Density

A Review of Stem Cell Therapy for Spinal Cord Injury: Large Animal Models and the Frontier in Humans

2017 ◽  
Vol 98 ◽  
pp. 438-443 ◽  
Author(s):  
Brandon C. Gabel ◽  
Erik I. Curtis ◽  
Martin Marsala ◽  
Joseph D. Ciacci
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Large Animal ◽  
Large Animal Models ◽  
Cord Injury

scholarly journals Large animal models for stem cell therapy

2013 ◽  
Vol 4 (2) ◽  
pp. 23 ◽  
Author(s):  
John Harding ◽  
R Roberts ◽  
Oleg Mirochnitchenko
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Stem Cells as Therapy for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis of Preclinical Studies

2020 ◽  
Vol 8 ◽  
Author(s):  
Eduardo Villamor-Martinez ◽  
Tamara Hundscheid ◽  
Boris W. Kramer ◽  
Carlijn R Hooijmans ◽  
Eduardo Villamor
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Necrotizing Enterocolitis ◽  
Stem Cell Therapy ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Intestinal Injury

Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal condition among very and extremely preterm infants. Stem cell therapy has shown some promising protective effects in animal models of intestinal injury, including NEC, but no systematic review has yet evaluated the preclinical evidence of stem cell therapy for NEC prevention or treatment.Methods: PubMed and EMBASE databases were searched for studies using an animal model of NEC with stem cells or their products. The SYRCLE tool was used for the assessment of risk of bias. A random-effects model was used to pool odds ratios (ORs) and 95% confidence interval (CI).Results: We screened 953 studies, of which nine (eight rat and one mouse models) met the inclusion criteria. All animal models induced NEC by a combination of hypothermia, hypoxia, and formula feeding. Risk of bias was evaluated as unclear on most items for all studies included. Meta-analysis found that both mesenchymal and neural stem cells and stem cell-derived exosomes reduced the incidence of all NEC (OR 0.22, 95% CI 0.16–0.32, k = 16), grade 2 NEC (OR 0.41, 95% CI 0.24–0.70, k = 16), and grade 3–4 NEC (OR 0.28, 95% CI 0.19–0.42, k = 16). k represents the number of independent effect sizes included in each meta-analysis. The effect of the exosomes was similar to that of the stem cells. Stem cells and exosomes also improved 4-day survival (OR 2.89 95% CI 2.07–4.04, k = 9) and 7-day survival (OR 3.96 95% CI 2.39–6.55, k = 5) after experimental NEC. Meta-analysis also found that stem cells reduced other indicators of intestinal injury.Conclusion: The data from this meta-analysis suggest that both stem cells and stem cell-derived exosomes prevented NEC in rodent experimental models. However, unclear risk of bias and incomplete reporting underline that poor reporting standards are common and hamper the reliable interpretation of preclinical evidence for stem cell therapy for NEC.

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