Chronotherapy as a potential approach to hypertensive patients with elevated heart rate?

1. Average supine circulating total catecholamine concentrations were found to be higher than the normal range in about 50% of patients with labile hypertension and in about 30% of patients with sustained essential hypertension. 2. These higher resting concentrations were mainly due to an increase in adrenaline in labile hypertension and to an increase in noradrenaline in sustained hypertension. 3. Patients with elevated catecholamine concentrations were also characterized by a higher heart rate, by an increased myocardial contractility and by greater hypotensive response after treatment with β-adrenoreceptor blocking agents. 4. These studies suggest the existence of subgroups of hypertensive patients with increased sympathetic tone.

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Associations of Daytime, Nighttime, and 24-Hour Heart Rate With Four Distinct Markers of Inflammation in Hypertensive Patients: The Styrian Hypertension Study

Journal of Clinical Hypertension ◽

10.1111/jch.12420 ◽

2014 ◽

Vol 16 (12) ◽

pp. 856-861 ◽

Cited By ~ 8

Author(s):

Bríain ó Hartaigh ◽

Martin Gaksch ◽

Katharina Kienreich ◽

Martin R. Grübler ◽

Nicolas Verheyen ◽

...

Keyword(s):

Heart Rate ◽

Hypertensive Patients ◽

Markers Of Inflammation

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Ramadan and blood pressure: importance of chronotherapy

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.154 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

MA Bejar ◽

I Zairi ◽

I Ben Mrad ◽

B Besbes ◽

K Mzoughi ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Dual Therapy ◽

Average Heart Rate ◽

Hypertensive Patients ◽

Mean Values ◽

Funding Sources ◽

Cardiology Department ◽

Group 2 ◽

And Gender

Abstract Funding Acknowledgements Type of funding sources: None. Background During Ramadan, alterations in the daily patterns of sleep, activities and medication timing might contribute to changes in blood pressure (BP) and heart rate among hypertensive patients. The aim of this study was to examine the effect of medication timing during Ramadan on blood pressure and heart rate in hypertensive subjects taking their treatment once daily. Methods The study prospectively recruited 44 hypertensive patients between April and June 2019, followed up at the cardiology department of our Hospital. A 24-hour pressure monitoring was carried out during two periods: prior to Ramadan and during the last ten days of Ramadan. Results We studied 29 women and 15 men, mean age was 58.7 years. 34% of the patients were diabetics and 16% had coronaropathy. 46% of the patients were on monotherapy, 43% on dual therapy and 11% on a triple antihypertensive therapy. During Ramadan, 57% of the patients took their treatment during the dinner (group1), whereas 43% took their treatment during the Shour (group 2). Average 24hour blood pressure in the whole group was 129 ± 18/74 ± 10 mmHg before Ramadan and 129 ± 19/74 ± 10 mmHg during Ramadan (p > 0.05). Daytime and nighttime mean values of systolic and diastolic blood pressure as well as mean values of heart rate were not different between both periods regardless of age and gender. However, during Ramadan, those who took their treatment after dinner had significant higher values of 24 hour systolic BP, awake systolic and diastolic BP, asleep systolic and diastolic BP than those who took their treatment with the shour (p < 0.05). Conclusion In this study, there were no significant changes in systolic and diastolic blood pressures as well as heart rate during the 2 periods. However, during Ramadan, a slight superiority of taking the treatment with the shour is observed. Average values of BP and heart rate Group 1 Group 2 p 24 hour SBP (mmHg) 134 ± 23 122 ± 6 0.017 24 hour DBP (mmHg) 76 ± 12 70 ± 5 0.052 Awake SBP (mmHg) 138 ± 23 125 ± 6 0.012 Awake DBP (mmHg) 79 ± 12 73 ± 5 0.044 Asleep SBP (mmHg) 127 ± 26 114 ± 12 0.030 Asleep DBP (mmHg) 71 ± 13 65 ± 7 0.045 24 hour average heart rate (bpm) 71 ± 7 70 ± 6 0.524 Awake average heart rate (bpm) 76 ± 7 74 ± 7 0.322 Asleep average heart rate (bpm) 65 ± 7 65 ± 7 0.931 Average values of blood pressure and heart rate in both groups Abstract Figure. 24hour course of blood pressure

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Heart rate recovery after physical exertion tests in elderly hypertensive patients undergoing resistance training

Fisioterapia em Movimento ◽

10.1590/0103-5150.029.001.ao05 ◽

2016 ◽

Vol 29 (1) ◽

pp. 53-60

Author(s):

Murillo Jales Lins de Lira ◽

Ivan Daniel Bezerra Nogueira ◽

Juliana Fernandes de Souza ◽

Flávio Emanoel Souza de Melo ◽

Ingrid Guerra Azevedo ◽

...

Keyword(s):

Heart Rate ◽

Resistance Training ◽

Cardiorespiratory Fitness ◽

Elderly Women ◽

Heart Rate Recovery ◽

Walk Test ◽

Resistance Training Program ◽

Hypertensive Patients ◽

Elderly Hypertensive ◽

Elderly Hypertensive Patients

Abstract Introduction: Heart rate recovery after exercise is a valuable variable, associated with prognosis and it has been used as an indicator of cardiorespiratory fitness, especially in patients with heart disease, as hypertensive patients. Objective: This study aimed to analyze the response of heart rate recovery in elderly hypertensive patients undergoing a resistance training program. Methods: Sample was composed for 10 elderly women with a mean age of 70.7 ± 7.4 years. Exercise test and six-minute walk test were developed and we checked heart rate recovery in the 1st and 2nd minute post tests, before and after resistance training. Results: There was an increase in mean heart rate recovery in the analyzed minutes in both tests, but only in the 1st minute after six minutes walk test we found a significant increase (p = 0.02). Conclusion: The results suggest the efficacy of resistance training to improve cardiorespiratory fitness of elderly hypertensive patients.

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