scholarly journals Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain

2016 ◽  
Vol 173 (21) ◽  
pp. 3134-3144 ◽  
Author(s):  
James J Burston ◽  
Paul I Mapp ◽  
Sarir Sarmad ◽  
David A Barrett ◽  
Micah J Niphakis ◽  
...  
Keyword(s):  
Monoacylglycerol Lipase ◽  
Osteoarthritis Pain ◽  
Lipase Inhibition

scholarly journals Monoacylglycerol lipase inhibition attenuates acute and anticipatory nausea in rats

SURG Journal ◽  
2014 ◽  
Vol 7 (3) ◽  
pp. 21-29
Author(s):  
Rachel I. Downey ◽  
Cheryl L. Limebeer ◽  
Heather I. Morris ◽  
Linda A. Parker
Keyword(s):  
Receptor Antagonist ◽  
Receptor Activation ◽  
Cb1 Receptor ◽  
Monoacylglycerol Lipase ◽  
Anticipatory Nausea ◽  
Acute Nausea ◽  
Sr 141716 ◽  
Cb1 Receptor Antagonist ◽  
Lipase Inhibition

This study investigates the role of the endocannabinoid 2-arachidonyl glycerol (2-AG) in regulating acute and anticipatory nausea in rats using the conditioned gaping model. The animals were systemically pretreated with MJN110, a selective monoacylglycerol lipase (MAGL) inhibitor, to enhance endogenous levels of 2-AG. Acute nausea was assessed using the taste reactivity model in which a flavour, saccharin, was paired with the administration of the emetic agent, lithium chloride (LiCl). Anticipatory nausea was assessed using a model of contextually elicited conditioned gaping in which a context was paired with the emetic agent, LiCl. Results indicated that MJN110 at the 10.0 mg kg-1 and 20.0 mg kg-1 dosage significantly attenuated acute and anticipatory nausea, as displayed by the significant reduction in mean number of gapes. This suppression was mediated by CB1 receptor activation as displayed by reversal of such effects when MJN110 was coadministered with the CB1 receptor antagonist, SR 141716. The results suggest that enhancement of endogenous 2-AG levels by MAGL inhibition may have anti-emetic potential. Keywords: 2-arachidonyl glycerol; monoacylglycerol lipase; endocannabinoid; nausea; conditioned gaping; CB1 receptor

Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice

2006 ◽  
Vol 211 (1) ◽  
pp. 78-83 ◽  
Author(s):  
Gary B. Quistad ◽  
Rebecka Klintenberg ◽  
Pierluigi Caboni ◽  
Shannon N. Liang ◽  
John E. Casida
Keyword(s):  
Organophosphorus Compounds ◽  
Monoacylglycerol Lipase ◽  
Lipase Inhibition

scholarly journals Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12‐Week, Randomized, Controlled Study

2021 ◽  
Author(s):  
Kirsten R. Müller‐Vahl ◽  
Carolin Fremer ◽  
Chan Beals ◽  
Jelena Ivkovic ◽  
Henrik Loft ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Monoacylglycerol Lipase ◽  
Randomized Controlled ◽  
Lipase Inhibition

Endocannabinoids and sleep: impact of monoacylglycerol lipase inhibition in rodent models

2019 ◽  
Vol 64 ◽  
pp. S99
Author(s):  
C. Dugovic ◽  
S. Yun ◽  
T. Lovenberg ◽  
P. Bonaventure
Keyword(s):  
Monoacylglycerol Lipase ◽  
Rodent Models ◽  
Lipase Inhibition

Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis

2019 ◽  
Vol 131 ◽  
pp. 109321
Author(s):  
Anu Chinnadurai ◽  
Geraint Berger ◽  
Ian Burkovskiy ◽  
Juan Zhou ◽  
Ashley Cox ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Monoacylglycerol Lipase ◽  
Potential Treatment ◽  
Lipase Inhibition
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