Novel peptidomimetic peptide deformylase (PDF) inhibitors of Mycobacterium tuberculosis

2020 ◽  
Vol 97 (1) ◽  
pp. 148-156
Author(s):  
Kunal M. Gokhale ◽  
Vikas N. Telvekar
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Peptide Deformylase

scholarly journals Glycine in the conserved motif III modulates the thermostability and oxidative stress resistance of peptide deformylase in Mycobacterium tuberculosis

2011 ◽  
Vol 320 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Sai Shyam Narayanan ◽  
Pandian Sokkar ◽  
Murugesan Ramachandran ◽  
Kesavan Madhavan Nampoothiri
Keyword(s):  
Oxidative Stress ◽  
Mycobacterium Tuberculosis ◽  
Stress Resistance ◽  
Peptide Deformylase ◽  
Conserved Motif ◽  
Oxidative Stress Resistance ◽  
And Oxidative Stress

Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results

2008 ◽  
Vol 18 (24) ◽  
pp. 6568-6572 ◽  
Author(s):  
Arkadius Pichota ◽  
Jeyaraj Duraiswamy ◽  
Zheng Yin ◽  
Thomas H. Keller ◽  
Jenefer Alam ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Peptide Deformylase ◽  
Structural Investigations

scholarly journals Identification of Regions Involved in Enzymatic Stability of Peptide Deformylase of Mycobacterium tuberculosis

2005 ◽  
Vol 187 (23) ◽  
pp. 8216-8220 ◽  
Author(s):  
Rahul Saxena ◽  
Pradip K. Chakraborti
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Sequence Analysis ◽  
Peptide Deformylase ◽  
Deletion Mutants ◽  
Oxidizing Agents ◽  
Enzymatic Stability ◽  
Carboxy Terminal

ABSTRACT Sequence analysis of peptide deformylase of Mycobacterium tuberculosis revealed the presence of insertions (residues 74 to 85) and an unusually long carboxy-terminal end (residues 182 to 197). Our results with deletion mutants indicated the contribution of these regions in maintaining enzymatic stability. Furthermore, we showed that the region spanning the insertions was responsible for maintaining resistance to oxidizing agents, like H2O2.

Targeting the Peptide Deformylase of Mycobacterium tuberculosis Leads to Drug Discovery

2009 ◽  
Vol 6 (7) ◽  
pp. 487-493 ◽  
Author(s):  
Vijai Singh ◽  
Pallavi Somvanshi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Drug Discovery ◽  
Peptide Deformylase

scholarly journals BB-3497, a peptide deformylase inhibitor, is active against Mycobacterium tuberculosis

2004 ◽  
Vol 53 (2) ◽  
pp. 403-b-405 ◽  
Author(s):  
M. H. Cynamon
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Peptide Deformylase

Discovery of Inhibitors for Mycobacterium Tuberculosis Peptide Deformylase Based on Virtual Screening in Silico

2021 ◽  
pp. 2100002
Author(s):  
Xinpeng Li ◽  
Qihua Jiang ◽  
Xiaolan Yang
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Virtual Screening ◽  
In Silico ◽  
Peptide Deformylase

In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv

2009 ◽  
Vol 34 (3) ◽  
pp. 226-230 ◽  
Author(s):  
Anshika Sharma ◽  
Sadhna Sharma ◽  
G.K. Khuller ◽  
A.J. Kanwar
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Ex Vivo ◽  
Tuberculosis H37rv ◽  
Peptide Deformylase ◽  
Mycobacterium Tuberculosis H37rv
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