scholarly journals C 3 dysregulation due to factor H deficiency is mannan‐binding lectin‐associated serine proteases ( MASP )‐1 and MASP ‐3 independent in vivo

2014 ◽  
Vol 176 (1) ◽  
pp. 84-92 ◽  
Author(s):  
M. M. Ruseva ◽  
M. Takahashi ◽  
T. Fujita ◽  
M. C. Pickering
Keyword(s):  
Serine Proteases ◽  
Factor H ◽  
Factor H Deficiency ◽  
Mannan Binding Lectin ◽  
Binding Lectin

C3 dysregulation due to factor H deficiency is MASP-1/3 independent in vivo

2013 ◽  
Vol 56 (3) ◽  
pp. 253
Author(s):  
M.M. Ruseva ◽  
M. Takahashi ◽  
T. Fujita ◽  
M.C. Pickering
Keyword(s):  
Factor H ◽  
Factor H Deficiency

scholarly journals Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control

2015 ◽  
Vol 180 (2) ◽  
pp. 227-232 ◽  
Author(s):  
L. Jenny ◽  
R. Ajjan ◽  
R. King ◽  
S. Thiel ◽  
V. Schroeder
Keyword(s):  
Type 1 Diabetes ◽  
Glycaemic Control ◽  
Plasma Levels ◽  
Serine Proteases ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals The Two Major Oligomeric Forms of Human Mannan-Binding Lectin: Chemical Characterization, Carbohydrate-Binding Properties, and Interaction with MBL-Associated Serine Proteases

2005 ◽  
Vol 174 (5) ◽  
pp. 2870-2877 ◽  
Author(s):  
Florence Teillet ◽  
Bernard Dublet ◽  
Jean-Pierre Andrieu ◽  
Christine Gaboriaud ◽  
Gérard J. Arlaud ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Chemical Characterization ◽  
Carbohydrate Binding ◽  
Binding Properties ◽  
Mannan Binding Lectin ◽  
Binding Lectin ◽  
Oligomeric Forms

scholarly journals Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Esben Axelgaard ◽  
Jakob Appel Østergaard ◽  
Steffen Thiel ◽  
Troels Krarup Hansen
Keyword(s):  
Diabetic Nephropathy ◽  
Complement System ◽  
Knockout Mice ◽  
Ex Vivo ◽  
Lectin Pathway ◽  
Urine Albumin ◽  
Mannan Binding Lectin ◽  
The Complement System ◽  
Binding Lectin

Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or to altered self-tissue. Our group have previously shown direct effects of MBL on diabetes-induced kidney damage, and we hypothesized that MBL may cause autoactivation of the complement system via binding to neoepitopes induced by hyperglycemia. In the present study, we induced diabetes in MBL knockout mice and in wild type C57BL/6J mice by low-dose streptozotocin injection and measured blood glucose and urine albumin-to-creatinine ratio to monitor development of diabetes. After 24 weeks, fluorescently labelled recombinant MBL was injected intravenously in diabetic MBL knockout mice after which the distribution was investigated using in vivo fluorescence imaging. Mice were subjected to in vivo and ex vivo imaging 24 hours after injection. MBL was found to accumulate in the kidneys of diabetic mice as compared to healthy control mice (p<0.0001). These findings support the hypothesis of a significant role of MBL and the complement system in the pathophysiology of diabetic nephropathy.

scholarly journals Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

2018 ◽  
Vol 3 (2) ◽  
pp. 426-438 ◽  
Author(s):  
Nicholas R. Medjeral-Thomas ◽  
Anne Troldborg ◽  
Nicholas Constantinou ◽  
Hannah J. Lomax-Browne ◽  
Annette G. Hansen ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Serine Protease ◽  
Factor H ◽  
Related Protein ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Identification of the Site of Human Mannan-Binding Lectin Involved in the Interaction with Its Partner Serine Proteases: The Essential Role of Lys55

2007 ◽  
Vol 178 (9) ◽  
pp. 5710-5716 ◽  
Author(s):  
Florence Teillet ◽  
Monique Lacroix ◽  
Steffen Thiel ◽  
Dietmar Weilguny ◽  
Teit Agger ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Essential Role ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation

2014 ◽  
Vol 59 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Katalin Paréj ◽  
Ágnes Hermann ◽  
Nóra Donáth ◽  
Péter Závodszky ◽  
Péter Gál ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Association Studies ◽  
Interaction Domains ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Characterization of the Interaction Between L-Ficolin/P35 and Mannan-Binding Lectin-Associated Serine Proteases-1 and -2

2002 ◽  
Vol 169 (10) ◽  
pp. 5735-5743 ◽  
Author(s):  
Sandor Cseh ◽  
Loanys Vera ◽  
Misao Matsushita ◽  
Teizo Fujita ◽  
Gérard J. Arlaud ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

2013 ◽  
Vol 288 (13) ◽  
pp. 8922-8934 ◽  
Author(s):  
Márton Megyeri ◽  
Veronika Harmat ◽  
Balázs Major ◽  
Ádám Végh ◽  
Júlia Balczer ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Lectin Pathway ◽  
Quantitative Characterization ◽  
Mannan Binding Lectin ◽  
Binding Lectin
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