Osteoclast-like cells on deproteinized bovine bone mineral and biphasic calcium phosphate: light and transmission electron microscopical observations

2014 ◽  
Vol 26 (8) ◽  
pp. 859-864 ◽  
Author(s):  
Simon S. Jensen ◽  
Reinhard Gruber ◽  
Daniel Buser ◽  
Dieter D. Bosshardt
2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Carole Chakar ◽  
Nada Naaman ◽  
Emmanuel Soffer ◽  
Nicolas Cohen ◽  
Nada El Osta ◽  
...  

Bone substitutes alone or supplemented with platelet-derived concentrates are widely used to promote bone regeneration but their potency remains controversial. The aim of this study was, therefore, to compare the regenerative potential of preparations containing autologous platelet lysate (APL) and particles of either deproteinized bovine bone mineral (DBBM) or biphasic calcium phosphate (BCP), two bone substitutes with different resorption patterns. Rabbit APL was prepared by freeze-thawing a platelet suspension. Critical-size defects in rabbit femoral condyle were filled with DBBM or DBBM+APL and BCP or BCP+APL. Rabbits were sacrificed after six weeks and newly formed bone and residual implanted material were evaluated using nondemineralized histology and histomorphometry. New bone was observed around particles of all fillers tested. In the defects filled with BCP, the newly formed bone area was greater (70%;P<0.001) while the residual material area was lower (60%;P<0.001) than that observed in those filled with DBBM. New bone and residual material area of defects filled with either APL+DBBM or APL+BCP were similar to those observed in those filled with the material alone. In summary, osteoconductivity and resorption of BCP were greater than those of DBBM, while APL associated with either DBBM or BCP did not have an additional benefit.


2013 ◽  
Vol 25 (7) ◽  
pp. 786-790 ◽  
Author(s):  
Jan Lindhe ◽  
Denis Cecchinato ◽  
Mauro Donati ◽  
Cristiano Tomasi ◽  
Birgitta Liljenberg

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