scholarly journals Bone Formation with Deproteinized Bovine Bone Mineral or Biphasic Calcium Phosphate in the Presence of Autologous Platelet Lysate: Comparative Investigation in Rabbit

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Carole Chakar ◽  
Nada Naaman ◽  
Emmanuel Soffer ◽  
Nicolas Cohen ◽  
Nada El Osta ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Substitutes ◽  
Platelet Lysate ◽  
Bovine Bone ◽  
Residual Material ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Autologous Platelet ◽  
Deproteinized Bovine Bone

Bone substitutes alone or supplemented with platelet-derived concentrates are widely used to promote bone regeneration but their potency remains controversial. The aim of this study was, therefore, to compare the regenerative potential of preparations containing autologous platelet lysate (APL) and particles of either deproteinized bovine bone mineral (DBBM) or biphasic calcium phosphate (BCP), two bone substitutes with different resorption patterns. Rabbit APL was prepared by freeze-thawing a platelet suspension. Critical-size defects in rabbit femoral condyle were filled with DBBM or DBBM+APL and BCP or BCP+APL. Rabbits were sacrificed after six weeks and newly formed bone and residual implanted material were evaluated using nondemineralized histology and histomorphometry. New bone was observed around particles of all fillers tested. In the defects filled with BCP, the newly formed bone area was greater (70%;P<0.001) while the residual material area was lower (60%;P<0.001) than that observed in those filled with DBBM. New bone and residual material area of defects filled with either APL+DBBM or APL+BCP were similar to those observed in those filled with the material alone. In summary, osteoconductivity and resorption of BCP were greater than those of DBBM, while APL associated with either DBBM or BCP did not have an additional benefit.

scholarly journals Minocycline Hydrochloride as a Potential Adjuvant to Improve Osteoconductive and Osteoinductive Properties of Bone Substitutes in an Extra-Skeletal Bone Augmentation Model: Preliminary Observations in Rats

2021 ◽  
Vol 2 (01) ◽  
pp. 1-5
Author(s):  
Bob Biewer ◽  
Dorien Van Hede ◽  
Eric Rompen ◽  
Michel Mittelbronn ◽  
Pascale Quatresooz ◽  
...  
Keyword(s):  
Bone Substitutes ◽  
The Other ◽  
Bovine Bone ◽  
Bone Augmentation ◽  
Control Groups ◽  
Minocycline Hydrochloride ◽  
Skeletal Bone ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Deproteinized Bovine Bone

Abstract Objectives The present study was performed to determine if minocycline HCl could influence the behavior of deproteinized bovine bone mineral (DBBM) and bioactive glass (BG) particles when used as filler material for new bone generation in a guided bone augmentation model. Materials and Methods Two occlusive titanium caps were placed on the rat calvaria. One filled with BG particles, the second with DBBM particles, both previously mixed with blood (control). In minocycline HCl loaded groups (experimental), grafts were additionally placed into a minocycline solution. Samples were harvested after 4, 8, and 16 weeks. Half of the samples were embedded in methylmethacrylate for undecalcified histology and the other half was fixed, decalcified, and embedded in paraffin for classical histologic analysis. Results The control groups highlighted osteoconductive and osteoinductive responses associated to BG particles, as well as an osteoconductive reaction, in DBBM sections. The addition of minocycline HCl to BG particles had no measurable influence on the result. In minocycline HCl loaded DBBM sections; however, areas of spontaneous ossification could be observed after 8 and 16 weeks. Conclusion Our observations suggest that minocycline HCl may add some osteoinductive properties to DBBM within the limitations of this study design. Further investigations are needed to refine the present results.

Ridge preservation with the use of deproteinized bovine bone mineral

2013 ◽  
Vol 25 (7) ◽  
pp. 786-790 ◽  
Author(s):  
Jan Lindhe ◽  
Denis Cecchinato ◽  
Mauro Donati ◽  
Cristiano Tomasi ◽  
Birgitta Liljenberg
Keyword(s):  
Bone Mineral ◽  
Ridge Preservation ◽  
Bovine Bone ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Deproteinized Bovine Bone

scholarly journals Assessment of Bone Healing in Rabbit Calvaria Grafted with Three Different Biomaterials

2014 ◽  
Vol 25 (5) ◽  
pp. 379-384 ◽  
Author(s):  
Carlos Alberto Yoshihiro Takauti ◽  
Fabio Futema ◽  
Rui Barbosa de Brito Junior ◽  
Aline Corrêa Abrahão ◽  
Claudio Costa ◽  
...  
Keyword(s):  
New Zealand ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Parietal Bone ◽  
The Other ◽  
Bovine Bone ◽  
Bone Induction ◽  
Induction Process ◽  
New Zealand White Rabbits ◽  
Deproteinized Bovine Bone

This study evaluated the bone regeneration process in rabbit calvaria induced by three types of biomaterials: two xenogenous, consisting of deproteinized bovine bone, while the other was alloplastic, based on biphasic calcium phosphate. Five New Zealand white rabbits weighing between 2,900 and 3,500 g were submitted to four standard 8 mm-diameter perforations at the parietal bone. Three perforations were filled with three grafts and biomaterials, two of them received bovine Bio-Oss(r) and Endobon(r) Xenograft Granules, and the other consisted of fully alloplastic Straumann(r) Bone Ceramic. The fourth remaining cavity was used as control with coagulum. After eight weeks, the animals were sacrificed, and the samples were prepared for morphometric and qualitative analysis. The cavities filled with alloplastic biomaterials showed higher percentages of newly formed bone (p<0.05), while the cavities with xenogenous biomaterials showed higher amount of residual graft (p<0.05). Although the results showed greater bone formation with Straumann(r) Bone Ceramic, further studies are required to prove which is the more effective biomaterial for bone induction process.

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