Allergic contact dermatitis caused by topical ketoconazole: a relevant issue? Review of ketoconazole-positive patch tests

2018 ◽  
Vol 78 (3) ◽  
pp. 234-236 ◽  
Author(s):  
Rosana Lazzarini ◽  
Mariana F. S. Hafner ◽  
Barbara A. F. Miguel ◽  
Nathalia T. Kawakami ◽  
Beatriz H. Y. Nakagome
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Relevant Issue ◽  
Patch Tests ◽  
Allergic Contact

scholarly journals Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between 2004 and 2017

2020 ◽  
Vol 95 (6) ◽  
pp. 696-701
Author(s):  
Mariana de Figueiredo Silva Hafner ◽  
Ana Carolina Rodrigues ◽  
Rosana Lazzarini
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Retrospective Analysis ◽  
Patch Tests ◽  
Allergic Contact

ENVIRONMENTAL DERMATITIS: PATCH TESTS IN 1,000 CASES OF ALLERGIC CONTACT DERMATITIS

1973 ◽  
Vol 2 (14) ◽  
pp. 681-685 ◽  
Author(s):  
John N. Burry ◽  
John Kirk ◽  
John G. Reid ◽  
Tom Turner
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Tests ◽  
Allergic Contact

Patch Tests in Patients without History of Allergic Contact Dermatitis

Dermatitis ◽  
2007 ◽  
Vol 18 (2) ◽  
pp. 107
Author(s):  
Ida Duarte ◽  
Ohalis Luanda Fernanda Nunez ◽  
Rutsnei Schmitz
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Tests ◽  
History Of ◽  
Allergic Contact

Evaluating the Inclusiveness of Common Allergens in Expanded Series Patch Tests for Children in the Pediatric Allergic Contact Dermatitis Registry

2021 ◽  
Author(s):  
Reid W. Collis ◽  
Idy Tam ◽  
Alan Snyder ◽  
John Plante ◽  
Eric Grisham ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Tests ◽  
Allergic Contact

The development of allergic contact dermatitis in females during the comparison of two predictive patch tests

1977 ◽  
Vol 3 (1) ◽  
pp. 19-26 ◽  
Author(s):  
William P. Jordan ◽  
Sarah E. King
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Tests ◽  
Allergic Contact

scholarly journals Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine

2016 ◽  
Vol 82 (6) ◽  
pp. 645 ◽  
Author(s):  
Hyun-Chang Ko ◽  
Hyun-Joo Lee ◽  
Won-Jeong Kim ◽  
Jun-Young Kim ◽  
Hoon-Soo Kim ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Hair Dye ◽  
Patch Tests ◽  
Allergic Contact

scholarly journals Patch and Photo-Patch Testing are Important in Patients with Idiopathic Photodermatoses

2018 ◽  
Vol 75 (4) ◽  
pp. 327-328
Author(s):  
An Goossens ◽  
Maria Margarida Gonçalo
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Testing ◽  
European Society ◽  
False Negative ◽  
Uv Filters ◽  
Thiourea Derivatives ◽  
Patch Tests ◽  
Chronic Actinic Dermatitis ◽  
Allergic Contact

This number of the Revista da Sociedade Portuguesa de Dermatologia e Venereologia contains two articles dedicated to idiopathic photodermatoses, for which autoimmune reactions to an unknown endogenous chromophore are suspected to be involved – polymorphous light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis, and solar urticarial.1,2 Many of these and other photodermatoses have a very clear clinical presentation, while others may mimic allergic contact dermatitis (ACD) or photo-allergic contact dermatitis (PhACD), a classical T cell-mediated or delayed type IV hypersensitivity reaction to an exogenous chromophore applied on the skin in the presence of, or followed by exposure to ultraviolet (UV) or visible light.3,4 Allergic contact reactions can be followed by persistent photosensitivity and chronic actinic dermatitis, such as in cases of chronic ACD from certain plants, e.g., Compositae that are rich in sesquiterpene lactones,5 fragrances, lichens, and colophony,4 or in PhACD or photo-aggravated ACD from drugs like ketoprofen, etofenamate, and chlorproethazine, or even other contact allergens, such as tosylamide/formaldehyde resin, fragrances, and thiourea derivatives.4The long persistence of these chemicals in the epidermis (for up to at least 17 days in the case of ketoprofen),6 or the formation of endogenous photosensitizers might perhaps explain the progression to chronic actinic dermatitis.4In patients with idiopathic photodermatoses the use of sunscreens is mandatory, however, the sensitization risk from these chemicals may be enhanced by the previous skin inflammation and the need for repeated application for long periods.7 UV filters, which are chromophores that capture UV light, are among the most frequent causes of PhACD,8-11 namely benzophenones, dibenzoylmethane derivatives, octocrylene, and cinammates.9,10,12-14 Although more recent UV filters seem to be more photostable and less prone to induce PhACD,3 a few cases have been described,9 for example, from polysilicone-15 (Parsol®SLX).15 With regard to methylene bis-benzotriazolyl tetramethylbutylphenol (syn. bisoctrizole or Tinosorb® M), ACD from it is due to the surfactant decyl glucoside, in particular, which is added in order to stabilize the sunscreen molecule.16,17Topical drugs, such as the non-steroidal anti-inflammatory ketoprofen, piketoprofen, suprofen, etofenamate, piroxicam, and benzydamine,18 as well as phenothiazine derivatives, i.e., promethazine or chlorproethazine, and isothipendyl chlorhydrate19 are frequent causes of ACD/PhACD, either by direct application or by transfer from other individuals in close contact (consort or connubial dermatitis). Moreover, some of these chemicals, particularly ketoprofen, exhibit cross-reactions with UV filters, i.e., benzophenone(s) and octocrylene, the latter containing benzophenone residues. Also fenofibrate, a systemic drug, shares the benzophenone ring and can cross react with ketoprofen and related molecules.3,20 Furthermore, patients with PhACD from ketoprofen present with concomitant reactions to the perfume ingredient cinnamic alcohol, reactions that at present are difficult to explain by cross-reactivity.21Therefore, patch and photo-patch testing are highly recommended in patients with idiopathic and autoimmune photodermatoses, as well as in all other diseases aggravated by sunlight, in order to detect and avoid exposure to possible aggravating factors, and particularly to UV filters. Recently, recommendations for diagnostic patch testing have been issued by the European Society of Contact Dermatitis (ESCD),22 and in a cooperative effort of the ESCD and European Society of Photodermatology (ESPD), an agreement was not only reached regarding standardized protocols for photo-patch testing,23 but also on the list of 20 allergens to be included in the European baseline photo-patch tests series and an additional extended series including certain classical photo-allergens.24 Last but not least, photo-patch tests with all the patient’s own topical products and systemic photosensitizers to which the patients is exposed are strongly recommended as well, since the outcome may further contribute to the relevance of positive reactions observed, or avoid “false”- negative reactions obtained by testing standardized allergens only.24

Sign in / Sign up

Export Citation Format

Share Document