Prognostic significance of lymph node yield after long-course preoperative radiotherapy in patients with rectal cancer: a systematic review

2013 ◽  
Vol 15 (4) ◽  
pp. 394-403 ◽  
Author(s):  
G. E. H. Awwad ◽  
S. I. H. Tou ◽  
N. A. Rieger
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Preoperative Radiotherapy ◽  
Prognostic Significance ◽  
Lymph Node Yield ◽  
Long Course ◽  
Node Yield

scholarly journals Lymph node yield after rectal resection in patients treated with neoadjuvant radiation for rectal cancer: A systematic review and meta-analysis

2017 ◽  
Vol 72 ◽  
pp. 84-94 ◽  
Author(s):  
Robert Mechera ◽  
Tibor Schuster ◽  
Robert Rosenberg ◽  
Benjamin Speich
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Rectal Resection ◽  
Meta Analysis ◽  
Lymph Node Yield ◽  
Node Yield

Prognostic significance of lymph node yield in ypN0 rectal cancer

2016 ◽  
Vol 103 (12) ◽  
pp. 1731-1737 ◽  
Author(s):  
M. Raoof ◽  
R. A. Nelson ◽  
V. N. Nfonsam ◽  
J. Warneke ◽  
R. S. Krouse
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Significance ◽  
Lymph Node Yield ◽  
Node Yield

Lymph node yield during surgery after neoadjuvant therapy compared to surgery without neoadjuvant therapy in patients with esophageal, gastric, pancreatic, or rectal carcinoma: systematic review and meta-analysis (Preprint)

2021 ◽  
Author(s):  
Ulrich Ronellenfitsch ◽  
Nika Maximov ◽  
Juliane Friedrichs ◽  
Jorg Kleeff
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Neoadjuvant Therapy ◽  
Meta Analysis ◽  
Neoadjuvant Treatment ◽  
Surrogate Marker ◽  
Lymph Node Yield ◽  
Gastrointestinal Carcinomas ◽  
Node Yield

BACKGROUND The lymph node yield is an important surrogate parameter for assessing the oncological radicality of the resection of gastrointestinal carcinomas and a prognostic factor in these diseases. It remains unclear if and to what extent neoadjuvant chemotherapy, radiotherapy or chemoradiotherapy, which have become established treatments for carcinoma of the esophagus, stomach, and rectum and are increasingly used in pancreatic carcinoma, affect the lymph node yield. OBJECTIVE This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the oncological surrogate marker lymph node yield in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant treatment compared to those operated without neoadjuvant therapy. METHODS Studies comparing oncological resection of esophageal, stomach, pancreatic and rectal carcinoma with and without prior neoadjuvant therapy are eligible for inclusion regardless of study design. Publications will be identified with a defined search strategy in the electronic databases PubMed and Cochrane Library. The primary endpoint of the analysis is the number of lymph nodes identified in the resected specimen. Secondary endpoints include number of harvested metastatic lymph nodes, operation time, postoperative complications, pTNM staging, and overall and recurrence-free survival time. Using suitable statistical methods, the endpoints between patients with and without neoadjuvant therapy as well as in defined subgroups (neoadjuvant chemotherapy, neoadjuvant radiotherapy, neoadjuvant chemoradiotherapy, and esophageal, gastric, pancreatic, and rectal cancer) will be compared. RESULTS As of October 2021, we started with the data collection. CONCLUSIONS This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the oncological surrogate marker lymph node yield in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant treatment compared to those operated without neoadjuvant therapy. CLINICALTRIAL This systematic review is registered at PROSPERO, ID: 218459.

scholarly journals Can Ex Vivo Magnetic Resonance Imaging of Rectal Cancer Specimens Improve the Mesorectal Lymph Node Yield for Pathological Examination?

2019 ◽  
Vol 54 (10) ◽  
pp. 645-652 ◽  
Author(s):  
Rutger Stijns ◽  
Bart Philips ◽  
Carla Wauters ◽  
Johannes de Wilt ◽  
Iris Nagtegaal ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Magnetic Resonance ◽  
Ex Vivo ◽  
Pathological Examination ◽  
Resonance Imaging ◽  
Lymph Node Yield ◽  
Mesorectal Lymph Node ◽  
Node Yield

Lymph node yield in rectal cancer surgery: Effect of preoperative chemoradiotherapy

2010 ◽  
Vol 36 (4) ◽  
pp. 345-349 ◽  
Author(s):  
B. Morcos ◽  
B. Baker ◽  
M. Al Masri ◽  
H. Haddad ◽  
S. Hashem
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Preoperative Chemoradiotherapy ◽  
Cancer Surgery ◽  
Rectal Cancer Surgery ◽  
Lymph Node Yield ◽  
Node Yield

Lymph node yield is an independent predictor of survival in rectal cancer regardless of receipt of neoadjuvant therapy

2016 ◽  
Vol 70 (7) ◽  
pp. 584-592 ◽  
Author(s):  
Zhaomin Xu ◽  
Mariana E Berho ◽  
Adan Z Becerra ◽  
Christopher T Aquina ◽  
Bradley J Hensley ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Neoadjuvant Therapy ◽  
Neoadjuvant Treatment ◽  
Neoadjuvant Chemoradiation ◽  
Mixed Effects ◽  
Patient Factors ◽  
Lymph Node Yield ◽  
Factors Associated ◽  
Node Yield

AimsLymph node yield (LNY) is used as a marker of adequate oncological resection. The American Joint Committee on Cancer (AJCC) currently recommends that at least 12 nodes are necessary to confirm node-negative disease for rectal cancer. A LNY of 12 is not always achieved, particularly in patients who have undergone neoadjuvant treatment. This study attempts to examine factors associated with LNY and its prognostic impact following neoadjuvant chemoradiation in rectal cancer.MethodsThe 2006–2011 National Cancer Data Base was queried for patients with clinical stage I–III rectal cancer who underwent a proctectomy. Suboptimal LNY was defined as <12 lymph nodes examined. A mixed-effects multinomial logistic regression model was used to identify independent factors associated with LNY. Mixed-effects Cox proportional hazards models were used to estimate the adjusted effect of LNY on 5-year overall survival.Results25 447 patients met inclusion criteria. Overall, 62% of the cohort received neoadjuvant chemoradiation and 32% had suboptimal LNY. The median LNY for patients who received neoadjuvant therapy was 13 (IQR: 9–18) and for patients who did not receive neoadjuvant therapy was 15 (IQR: 12–21). After risk adjustment, there was a 3.5-fold difference in the rate of suboptimal LNY among individual hospitals (27%–95%). Suboptimal LNY was independently associated with an 18% increased hazard of death among patients who did not receive neoadjuvant treatment and a 20% increased hazard of death among those who did receive neoadjuvant treatment when controlled for adjuvant treatment, staging, proximal/distal margins and other patient factors.ConclusionsSuboptimal LNY is independently associated with worse overall survival regardless of neoadjuvant therapy, pathological staging and patient factors in rectal cancer. This finding underlies the importance and challenge of an optimal lymph node evaluation for prognostication, especially for patients receiving neoadjuvant therapy.

scholarly journals Lower lymph node yield following neoadjuvant therapy for rectal cancer has no clinical significance

2018 ◽  
Vol 10 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Dedrick Kok Hong Chan ◽  
Ker-Kan Tan
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Neoadjuvant Therapy ◽  
Clinical Significance ◽  
Lymph Node Yield ◽  
Node Yield

scholarly journals Increased lymph node yield indicates improved survival in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

2019 ◽  
Vol 8 (10) ◽  
pp. 4615-4625 ◽  
Author(s):  
Yaqi Wang ◽  
Menglong Zhou ◽  
Jianing Yang ◽  
Xiaoyang Sun ◽  
Wei Zou ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiotherapy ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Lymph Node Yield ◽  
Node Yield

Preoperative Radiotherapy Decreases Lymph Node Yield of Neck Dissections for Head and Neck Cancer

2012 ◽  
Vol 147 (2) ◽  
pp. 278-280 ◽  
Author(s):  
Peter A. S. Johnstone ◽  
Eric D. Miller ◽  
Michael G. Moore
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Node ◽  
Head And Neck ◽  
Neck Cancer ◽  
Preoperative Radiotherapy ◽  
Lymph Node Yield ◽  
Node Yield

Prognostic influence of the lymph node yield in locally advanced rectal cancer treated with preoperative radiochemotherapy

2013 ◽  
Vol 18 ◽  
pp. S222-S223
Author(s):  
J. Gomez-millan Barrachina ◽  
M. Delgado Gil ◽  
L. Perez Villa ◽  
A. Román Jobacho ◽  
J. Rico Perez ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Preoperative Radiochemotherapy ◽  
Lymph Node Yield ◽  
Node Yield
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