scholarly journals Evaluation of Moxifloxacin in Canine and Non‐Human Primate Telemetry Assays: Comparison of QTc Interval Prolongation by Timepoint and Concentration‐QTc Analysis

2021 ◽  
Author(s):  
Ray W. Chui ◽  
Joel Baublits ◽  
Fiona A. Chandra ◽  
Zack W. Jones ◽  
Michael J. Engwall ◽  
...  
Keyword(s):  
Qtc Interval ◽  
Interval Prolongation ◽  
Qtc Interval Prolongation ◽  
Human Primate

scholarly journals Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mille K. Lyhne ◽  
Andreas Vegge ◽  
Gro Klitgaard Povlsen ◽  
Rita Slaaby ◽  
Jonas Kildegaard ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fold Increase ◽  
Diabetic Group ◽  
Large Animal ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Hyperinsulinaemic Hypoglycaemia ◽  
Large Animal Models ◽  
Qtc Interval Prolongation ◽  
Electrocardiographic Recordings

AbstractThe potentially fatal cardiovascular effects of hypoglycaemia are not well understood and large animal models of the counter-regulatory responses and cardiovascular consequences of insulin-induced hypoglycaemia are needed to understand the mechanisms in humans. The aim of this study was to develop a human-like minipig model of hypoglycaemia including healthy and diabetic pigs to investigate endocrine, electrocardiographic and platelet effects. Hypoglycaemia was induced using a hyperinsulinaemic, hypoglycaemic clamp and an insulin bolus protocol. Plasma glucose, glucagon, C-peptide, insulin, epinephrine and platelet aggregation responses were measured before, during and after hypoglycaemia. Continuous electrocardiographic recordings were obtained. Hypoglycaemia at a plasma glucose concentration of 0.8–1.0 mM in the clamp induced 25-fold increase in epinephrine and sixfold and threefold increase in glucagon for healthy and diabetic pigs, respectively. The hypoglycaemic clamp induced QTc-interval prolongation and increase in cardiac arrhythmias. In the bolus approach, the non-diabetic group reached plasma glucose target of 1.5 mM and QTc-interval was prolonged after insulin injection, but before glucose nadir. The diabetic group did not reach hypoglycaemic target, but still demonstrated QTc-interval prolongation. These results demonstrate effects of hyperinsulinaemic hypoglycaemia closely resembling human physiology, indicating the minipig as a translational animal model of counter-regulatory endocrine and myocardial effects of hypoglycaemia.

QTc interval prolongation in systemic sclerosis: Correlations with clinical variables

2015 ◽  
Vol 182 ◽  
pp. 20-22 ◽  
Author(s):  
E. Rosato ◽  
A. Gigante ◽  
M. Liberatori ◽  
M.L. Gasperini ◽  
L. Sardo ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Clinical Variables ◽  
Qtc Interval Prolongation

Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin

2002 ◽  
Vol 51 (3) ◽  
pp. 264-265 ◽  
Author(s):  
Benjamin A. Furst ◽  
Katherine M. Champion ◽  
Joseph M. Pierre ◽  
Donna A. Wirshing ◽  
William C. Wirshing
Keyword(s):  
Qtc Interval ◽  
Interval Prolongation ◽  
Qtc Interval Prolongation

Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development

2008 ◽  
Vol 44 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Giuseppe Curigliano ◽  
Gianluca Spitaleri ◽  
Howard J. Fingert ◽  
Filippo de Braud ◽  
Cristiana Sessa ◽  
...  
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Drug Induced ◽  
Qtc Interval Prolongation ◽  
Anticancer Drug Development

QTc interval prolongation in children with Turner syndrome: the results of exercise testing and 24-h ECG

2008 ◽  
Vol 168 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Robert Dalla Pozza ◽  
Susanne Bechtold ◽  
Simon Urschel ◽  
Heinrich Netz ◽  
Hans-Peter Schwarz
Keyword(s):  
Turner Syndrome ◽  
Exercise Testing ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Qtc Interval Prolongation

Translating the gap in the evaluation of drug-induced QTc-interval prolongation from in vivo to the clinic

2014 ◽  
Vol 70 (3) ◽  
pp. 324
Author(s):  
Vincent F.S. Dubois ◽  
Piet van der Graaf ◽  
Derek Leishman ◽  
David Gallacher ◽  
Nick McMahon ◽  
...  
Keyword(s):  
Qtc Interval ◽  
Interval Prolongation ◽  
Drug Induced ◽  
Qtc Interval Prolongation

QTc interval prolongation and hepatic encephalopathy in patients candidates for liver transplantation: A valid inference?

2015 ◽  
Vol 188 ◽  
pp. 43-44 ◽  
Author(s):  
Vincenzo Marafioti ◽  
Valentina Benetti ◽  
Umberto Montin ◽  
Vincenzo Carbone ◽  
Alfredo Petrosino ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatic Encephalopathy ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Valid Inference ◽  
Qtc Interval Prolongation
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