A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Na v 1.8 inhibitor, in healthy adults

Clinical and Translational Science ◽

10.1111/cts.13215 ◽

2021 ◽

Author(s):

Hemme J. Hijma ◽

Emilie M. J. Brummelen ◽

Pieter S. Siebenga ◽

Geert Jan Groeneveld

Keyword(s):

Phase I ◽

Dose Escalation ◽

Multiple Dose ◽

Healthy Adults ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Pharmacokinetics, Safety, and Tolerability of Intravenous Felbinac Trometamol in Healthy Chinese Volunteers: A First-in-Human Single- and Multiple-Dose Escalation Phase I Study with a Randomized, Double-Blind, Placebo-Controlled Design

CNS Drugs ◽

10.1007/s40263-020-00739-z ◽

2020 ◽

Vol 34 (8) ◽

pp. 867-877

Author(s):

Min Wu ◽

Cuiyun Li ◽

Hong Zhang ◽

Jixuan Sun ◽

Xiaoxue Zhu ◽

...

Keyword(s):

Phase I ◽

Dose Escalation ◽

Phase I Study ◽

Multiple Dose ◽

Double Blind ◽

Double Blind Placebo ◽

Healthy Chinese

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Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study

Clinical and Translational Science ◽

10.1111/cts.12929 ◽

2020 ◽

Cited By ~ 1

Author(s):

Ravi Shankar P. Singh ◽

Vivek Pradhan ◽

Erika S. Roberts ◽

Matthew Scaramozza ◽

Elizabeth Kieras ◽

...

Keyword(s):

Phase I ◽

Dose Escalation ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Erratum: A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

Molecular Psychiatry ◽

10.1038/mp.2016.140 ◽

2016 ◽

Vol 21 (10) ◽

pp. 1483-1484 ◽

Cited By ~ 5

Author(s):

M Fava ◽

K Johe ◽

L Ereshefsky ◽

L G Gertsik ◽

B A English ◽

...

Keyword(s):

Dose Escalation ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Depressed Patients ◽

Phase 1B

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A Randomized, Double‐Blind, Placebo‐Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX‐02 in Healthy Subjects

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.914 ◽

2021 ◽

Author(s):

Andi Leubitz ◽

Frederic Vanhoutte ◽

Ming‐yi Hu ◽

Kaela Porter ◽

Efrat Gordon ◽

...

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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A randomized, double-blind, placebo-controlled, single, and multiple dose-escalation Phase I clinical trial to investigate the safety, pharmacokinetic, and pharmacodynamic profiles of oral S086, a novel angiotensin receptor-neprilysin inhibitor, in healthy Chinese volunteers

Expert Opinion on Investigational Drugs ◽

10.1080/13543784.2021.1985464 ◽

2021 ◽

Author(s):

Yue Hu ◽

Hong Zhang ◽

Xiaojiao Li ◽

Jiajia Mai ◽

Lizhi Yang ◽

...

Keyword(s):

Clinical Trial ◽

Phase I ◽

Dose Escalation ◽

Multiple Dose ◽

Phase I Clinical Trial ◽

Angiotensin Receptor ◽

Double Blind ◽

Double Blind Placebo ◽

Neprilysin Inhibitor ◽

Angiotensin Receptor Neprilysin Inhibitor

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Phase I, randomized, double-blind, placebo-controlled, single-dose escalation study of the recombinant factor VIIa variant BAY 86-6150 in hemophilia

Journal of Thrombosis and Haemostasis ◽

10.1111/j.1538-7836.2012.04667.x ◽

2012 ◽

Vol 10 (5) ◽

pp. 773-780 ◽

Cited By ~ 31

Author(s):

J. N. MAHLANGU ◽

M. J. COETZEE ◽

M. LAFFAN ◽

J. WINDYGA ◽

T. T. YEE ◽

...

Keyword(s):

Single Dose ◽

Phase I ◽

Dose Escalation ◽

Recombinant Factor Viia ◽

Factor Viia ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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493 Safety Profile and Signal of Efficacy of a Non-Fcr-Binding, Fully Human Anti-Cd3 Monoclonal Antibody in Patients with Moderate to Severe Crohn's Disease- Results of a Phase I/Iia, Double Blind, Placebo-Controlled, Randomized, Dose Escalation Study

Gastroenterology ◽

10.1016/s0016-5085(08)60317-0 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-67 ◽

Cited By ~ 2

Author(s):

Christien J. van der Woude ◽

Pieter C. Stokkers ◽

Ad A. van Bodegraven ◽

Gert A. Van Assche ◽

Zbigniew Hebzda ◽

...

Keyword(s):

Monoclonal Antibody ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Phase I ◽

Dose Escalation ◽

Safety Profile ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Tolerability, pharmacokinetics and pharmacodynamics of the once-daily human GLP-1 analog liraglutide in Japanese healthy subjects: a randomized, double-blind, placebo-controlled dose-escalation study

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cpp46273 ◽

2008 ◽

Vol 46 (06) ◽

pp. 273-279 ◽

Cited By ~ 25

Author(s):

S. Irie ◽

Y. Matsumura ◽

M. Zdravkovic ◽

L.V. Jacobsen ◽

S. Kageyama

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Double Blind ◽

Once Daily ◽

Double Blind Placebo

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Pharmacokinetics and Safety Profile of Bleselumab (ASKP1240) in Patients With Moderate-To-Severe Plaque Psoriasis: Results from a Phase 2A, Randomized, Double-Blind, Placebo-Controlled, Sequential, Multiple-Dose Escalation Study

Clinical Therapeutics ◽

10.1016/j.clinthera.2017.05.208 ◽

2017 ◽

Vol 39 (8) ◽

pp. e68 ◽

Cited By ~ 1

Author(s):

M.S.A. Kumar ◽

R. Tainaka ◽

T. Zhu ◽

X. Wang ◽

J. Montgomery ◽

...

Keyword(s):

Dose Escalation ◽

Plaque Psoriasis ◽

Safety Profile ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Severe Plaque Psoriasis

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Faculty Opinions recommendation of A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13409136.14780164 ◽

2011 ◽

Author(s):

John Laffey ◽

Mairead Hayes

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Dose Escalation ◽

Human Mesenchymal Stem Cells ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adult Human

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