Tolerability, pharmacokinetics and pharmacodynamics of the once-daily human GLP-1 analog liraglutide in Japanese healthy subjects: a randomized, double-blind, placebo-controlled dose-escalation study

S. Irie; Y. Matsumura; M. Zdravkovic; L.V. Jacobsen; S. Kageyama

doi:10.5414/cpp46273

Tolerability, pharmacokinetics and pharmacodynamics of the once-daily human GLP-1 analog liraglutide in Japanese healthy subjects: a randomized, double-blind, placebo-controlled dose-escalation study

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cpp46273 ◽

2008 ◽

Vol 46 (06) ◽

pp. 273-279 ◽

Cited By ~ 25

Author(s):

S. Irie ◽

Y. Matsumura ◽

M. Zdravkovic ◽

L.V. Jacobsen ◽

S. Kageyama

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Double Blind ◽

Once Daily ◽

Double Blind Placebo

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A Randomized, Double‐Blind, Placebo‐Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX‐02 in Healthy Subjects

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.914 ◽

2021 ◽

Author(s):

Andi Leubitz ◽

Frederic Vanhoutte ◽

Ming‐yi Hu ◽

Kaela Porter ◽

Efrat Gordon ◽

...

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Na v 1.8 inhibitor, in healthy adults

Clinical and Translational Science ◽

10.1111/cts.13215 ◽

2021 ◽

Author(s):

Hemme J. Hijma ◽

Emilie M. J. Brummelen ◽

Pieter S. Siebenga ◽

Geert Jan Groeneveld

Keyword(s):

Phase I ◽

Dose Escalation ◽

Multiple Dose ◽

Healthy Adults ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Faculty Opinions recommendation of A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13409136.14780164 ◽

2011 ◽

Author(s):

John Laffey ◽

Mairead Hayes

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Dose Escalation ◽

Human Mesenchymal Stem Cells ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adult Human

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A Randomized Dose-Escalation Study on the Safety, Tolerability, Immunogenicity, Pharmacokinetics and Pharmacodynamics of a Novel Recombinant Human Albumin in Healthy Subjects

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2021.105923 ◽

2021 ◽

pp. 105923

Author(s):

Cuiyun Li ◽

Wei Xiang ◽

Min Wu ◽

Hong Zhang ◽

Jianqiu Cheng ◽

...

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Human Albumin ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Recombinant Human Albumin

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Relationship Between Absolute Neutrophil Count Profiles and Pharmacokinetics of DA-3031, a Pegylated Granulocyte Colony-Stimulating Factor (Pegylated-G-CSF): A Dose Block-Randomized, Double-Blind, Dose-Escalation Study in Healthy Subjects

Clinical Drug Investigation ◽

10.1007/s40261-013-0130-9 ◽

2013 ◽

Vol 33 (11) ◽

pp. 817-824 ◽

Cited By ~ 5

Author(s):

Li Young Ahn ◽

Kwang-Hee Shin ◽

Kyoung Soo Lim ◽

Tae-Eun Kim ◽

Hyewon Jeon ◽

...

Keyword(s):

Absolute Neutrophil Count ◽

Neutrophil Count ◽

Dose Escalation ◽

Healthy Subjects ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Dose Escalation Study ◽

Double Blind ◽

Stimulating Factor

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A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction

Yearbook of Cardiology ◽

10.1016/s0145-4145(10)79814-2 ◽

2010 ◽

Vol 2010 ◽

pp. 389-391 ◽

Cited By ~ 3

Author(s):

B.J. Gersh

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Dose Escalation ◽

Human Mesenchymal Stem Cells ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adult Human

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First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica

PLoS ONE ◽

10.1371/journal.pone.0125034 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125034 ◽

Cited By ~ 16

Author(s):

Paul E. Rolan ◽

Gilmore O’Neill ◽

Eve Versage ◽

Jitesh Rana ◽

Yongqiang Tang ◽

...

Keyword(s):

Family Member ◽

Cell Line ◽

Glial Cell ◽

Dose Escalation ◽

Neurotrophic Factor ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study

Clinical and Translational Science ◽

10.1111/cts.12929 ◽

2020 ◽

Cited By ~ 1

Author(s):

Ravi Shankar P. Singh ◽

Vivek Pradhan ◽

Erika S. Roberts ◽

Matthew Scaramozza ◽

Elizabeth Kieras ◽

...

Keyword(s):

Phase I ◽

Dose Escalation ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp203535 ◽

2020 ◽

Vol 58 (03) ◽

pp. 155-165

Author(s):

Chengxiao Fu ◽

Xingfei Zhang ◽

Qi Pei ◽

Chengxian Guo ◽

Xiaoyan Yang ◽

...

Keyword(s):

Single Dose ◽

Receptor Antagonist ◽

Muscarinic Receptor ◽

Dose Escalation ◽

Healthy Subjects ◽

Phase 1 ◽

Dose Escalation Study ◽

Double Blind ◽

Muscarinic Receptor Antagonist

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Safety and Immunogenicity of a Plant-Produced Recombinant Hemagglutinin-Based Influenza Vaccine (HAI-05) Derived from A/Indonesia/05/2005 (H5N1) Influenza Virus: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study in Healthy Adults

Viruses ◽

10.3390/v4113227 ◽

2012 ◽

Vol 4 (11) ◽

pp. 3227-3244 ◽

Cited By ~ 48

Author(s):

Jessica Chichester ◽

R. Jones ◽

Brian Green ◽

Mark Stow ◽

Fudu Miao ◽

...

Keyword(s):

Influenza Virus ◽

Influenza Vaccine ◽

Dose Escalation ◽

Phase 1 ◽

H5n1 Influenza Virus ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

H5n1 Influenza ◽

Recombinant Hemagglutinin

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