Status of
            Helicobacter pylori
            infection and gastric mucosal atrophy in patients with gastric cancer: Analysis based on the Japan Endoscopy Database

Abstract Background Serum pepsinogen (PG) levels correlate with the degree of gastric mucosal inflammation and atrophy, which correlate with gastric cancer risk, in patients infected with Helicobacter pylori (H. pylori). Serum PG levels change after eradication of H. pylori, but it is not known if there are corresponding changes in the gastric mucosa. We examined whether the degree of gastric atrophy correlated with PG levels measured after eradication of H. pylori. Methods We retrospectively examined the relationship between gastric atrophy and serum levels of PG I, PG II and PG I/II ratios measured after eradication of H. pylori. The degree of gastric mucosal atrophy before H. pylori eradication was scored (0, 1, 2) according to the Kyoto classification of gastritis. Results A total of 430 treated patients were enrolled. Serum levels of PG I (ρ = − 0.362 and P < 0.001), PG II (ρ = − 0.158 and P = 0.001) and PG I/II ratio (ρ = − 0.337 and P < 0.001) all correlated negatively with atrophy scores. When PG I/II was less than 3.4, 5.4 or 6.7, the probability of the open type of gastric atrophy was estimated to be 75%, 50%, or 25%, respectively. Conclusion Our results suggest that serum PG levels measured after H. pylori eradication can be used to estimate the degree of gastric mucosal atrophy and are useful for selecting individuals with a high risk of gastric cancer after H. pylori eradication.

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A Possible Link between Gastric Mucosal Atrophy and Gastric Cancer after Helicobacter pylori Eradication

PLoS ONE ◽

10.1371/journal.pone.0163700 ◽

2016 ◽

Vol 11 (10) ◽

pp. e0163700 ◽

Cited By ~ 6

Author(s):

Tomomitsu Tahara ◽

Tomoyuki Shibata ◽

Noriyuki Horiguchi ◽

Tomohiko Kawamura ◽

Masaaki Okubo ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Helicobacter Pylori Eradication ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy

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Tu1307 Possible Link Between Gastric Mucosal Atrophy and Gastric Cancer After Helicobacter pylori Eradication

Gastroenterology ◽

10.1016/s0016-5085(16)32933-x ◽

2016 ◽

Vol 150 (4) ◽

pp. S870-S871

Author(s):

Tomomitsu Tahara ◽

Tomoyuki Shibata ◽

Noriyuki Horiguchi ◽

Tomohiko Kawamura ◽

Masaaki Okubo ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Helicobacter Pylori Eradication ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy

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Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer

Journal of Medical Microbiology ◽

10.1099/jmm.0.060905-0 ◽

2013 ◽

Vol 62 (10) ◽

pp. 1571-1578 ◽

Cited By ~ 19

Author(s):

Seiji Shiota ◽

Varocha Mahachai ◽

Ratha-korn Vilaichone ◽

Thawee Ratanachu-ek ◽

Lotay Tshering ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Negative Group ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy ◽

High Prevalence ◽

Group A ◽

H Pylori ◽

Group B ◽

Group D

Gastric cancer is the second leading cause of cancer-related mortality in the world. Recently, serum Helicobacter pylori antibodies and pepsinogen (PG) have been used for gastric cancer screening. The incidence of gastric cancer in Bhutan is reported to be quite high compared with that in neighbouring countries. In this study, 381 subjects from three areas of Bhutan were assessed for gastric mucosal atrophy and serological parameters. Anti-H. pylori IgG, PG I, PG II and cytotoxin-associated gene A (CagA) antibodies were measured using ELISA. Subjects were classified into four groups according to H. pylori and PG seropositivity: Group A (H. pylori-negative/PG-negative), Group B (H. pylori-positive/PG-negative), Group C (H. pylori-positive/PG-positive) and Group D (H. pylori-negative/PG-positive). The prevalence of H. pylori in the 381 subjects was 71.1 % (271/381), with high infection rates found in rural areas. The PG I/II ratio was significantly inversely correlated with the atrophy score in the antrum and the corpus (P<0.001). Multivariate analysis showed that the PG status was significantly associated with the presence of atrophy in the corpus. The prevalence of the PG-positive status was significantly higher among H. pylori-positive subjects than among H. pylori-negative subjects (P<0.001). Based on the ABC method, Group B was the most dominant, followed by Group A, Group C and Group D. The high incidence of gastric cancer in Bhutan can be attributed to the high prevalence of H. pylori infection and gastric mucosal atrophy.

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