Painful diabetic peripheral neuropathy: role of oxidative stress and central sensitisation

2021 ◽  
Author(s):  
Di Ye ◽  
Timothy J. Fairchild ◽  
Lechi Vo ◽  
Peter D. Drummond
Keyword(s):  
Oxidative Stress ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Central Sensitisation ◽  
Painful Diabetic Peripheral Neuropathy

scholarly journals Long Non-coding RNA XIST Attenuates Diabetic Peripheral Neuropathy by Inducing Autophagy Through MicroRNA-30d-5p/sirtuin1 Axis

2021 ◽  
Vol 8 ◽  
Author(s):  
Bei-Yan Liu ◽  
Lin Li ◽  
Li-Wei Bai ◽  
Chang-Shui Xu
Keyword(s):  
Oxidative Stress ◽  
Peripheral Neuropathy ◽  
Schwann Cells ◽  
Diabetic Peripheral Neuropathy ◽  
Beclin 1 ◽  
Diabetic Mice ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Long Non Coding Rna

Diabetic peripheral neuropathy (DPN) is a prevalent diabetes mellitus (Feldman et al., 2017) complication and the primary reason for amputation. Meanwhile, long non-coding RNAs (lncRNAs) are a type of regulatory non-coding RNAs (ncRNAs) that broadly participate in DPN development. However, the correlation of lncRNA X-inactive specific transcript (XIST) with DPN remains unclear. In this study, we were interested in the role of XIST in the modulation of DPN progression. Significantly, our data showed that the expression of XIST and sirtuin1 (SIRT1) was inhibited, and the expression of microRNA-30d-5p (miR-30d-5p) was enhanced in the trigeminal sensory neurons of the diabetic mice compared with the normal mice. The levels of LC3II and Beclin-1 were inhibited in the diabetic mice. The treatment of high glucose (HG) reduced the XIST expression in Schwann cells. The apoptosis of Schwann cells was enhanced in the HG-treated cells, but the overexpression of XIST could block the effect in the cells. Moreover, the levels of LC3II and Beclin-1 were reduced in the HG-treated Schwann cells, while the overexpression of XIST was able to reverse this effect. The HG treatment promoted the production of oxidative stress, while the XIST overexpression could attenuate this result in the Schwann cells. Mechanically, XIST was able to sponge miR-30d-5p and miR-30d-5p-targeted SIRT1 in the Schwann cells. MiR-30d-5p inhibited autophagy and promoted oxidative stress in the HG-treated Schwann cells, and SIRT1 presented a reversed effect. MiR-30d-5p mimic or SIRT1 depletion could reverse XIST overexpression-mediated apoptosis and autophagy of the Schwann cells. Thus, we concluded that XIST attenuated DPN by inducing autophagy through miR-30d-5p/SIRT1 axis. XIST and miR-30d-5p may be applied as the potential targets for DPN therapy.

Role of Mechanoinsensitive Nociceptors in Painful Diabetic Peripheral Neuropathy

2021 ◽  
Vol 18 ◽  
Author(s):  
Mikhail I. Nemenov ◽  
Robinson J. Singleton ◽  
Louis S. Premkumar
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Small Diameter ◽  
Clinical Settings ◽  
Fiber Types ◽  
Axon Reflex ◽  
Pain Thresholds ◽  
C Fibers ◽  
Painful Diabetic Peripheral Neuropathy

: The cutaneous mechanisms that trigger spontaneous neuropathic pain in diabetic peripheral neuropathy (PDPN) are far from clear. Two types of nociceptors are found within the epidermal and dermal skin layers. Small-diameter lightly myelinated Aδ and unmyelinated C cutaneous mechano and heat sensitive (AMH and CMH) and C mechanoinsensitive (CMi) nociceptors transmit pain from the periphery to central nervous system. AMH and CMH fibers are mainly located in the epidermis and CMi fibers are distributed in the dermis. In DPN, dying back intra-epidermal AMH and CMH fibers leads to reduced pain sensitivity and the patients exhibit significantly increased pain thresholds to acute pain, when tested using traditional methods. The role of CMi fibers in painful neuropathies has not been fully explored. Microneurography has been the only tool to access CMi fibers and differentiate AMH, CMH and CMi fiber types. Due to the complexity, its use is impractical in clinical settings. In contrast, a newly developed diode laser fiber selective stimulation (DLss) technique allows to safely and selectively stimulate Aδ and C fibers in the superficial and deep skin layers. DLss data demonstrate that patients with painful DPN have increased Aδ fiber pain thresholds, while C-fiber thresholds are intact because in these patients CMi fibers are abnormally spontaneously active. It is also possible to determine the involvement of CMi fibers by measuring the area of DLss-induced neurogenic axon reflex flare. The differences in AMH, CMH and CMi fibers allow to identify patients with painful and painless neuropathy. In this review, we will discuss the role of CMi fibers in PDPN.

Molecular Basis of Diabetic Peripheral Neuropathy: Role of Oxidative Stress

2015 ◽  
Vol 3 (2) ◽  
pp. 123-124
Author(s):  
Nisha Rani Jamwal ◽  
◽  
Senthil P Kumar. ◽  
Keyword(s):  
Oxidative Stress ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Molecular Basis

scholarly journals Surgical Decompression of Painful Diabetic Peripheral Neuropathy: The Role of Pain Distribution

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109827 ◽  
Author(s):  
Chenlong Liao ◽  
Wenchuan Zhang ◽  
Min Yang ◽  
Qiufeng Ma ◽  
Guowei Li ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Surgical Decompression ◽  
Painful Diabetic Peripheral Neuropathy ◽  
Pain Distribution

scholarly journals What is the role of oxidative stress in the development of diabetic peripheral neuropathy?

2021 ◽  
Vol 5 (5) ◽  
pp. 408-411
Author(s):  
Tekin YILDIRIM ◽  
Ramazan ÖNALAN
Keyword(s):  
Oxidative Stress ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy

Role of Topiramate for the Treatment of Painful Diabetic Peripheral Neuropathy

2004 ◽  
Vol 24 (9) ◽  
pp. 1186-1193 ◽  
Author(s):  
Dana G. Carroll ◽  
Kristina M. Kline ◽  
Karen F. Malnar
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Painful Diabetic Peripheral Neuropathy
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