Rosiglitazone lowers resting and blood pressure response to exercise in men with type 2 diabetes: A 1‐year randomized study

2018 ◽  
Vol 20 (7) ◽  
pp. 1740-1750 ◽  
Author(s):  
Marie‐Eve Piché ◽  
Anne‐Sophie Laberge ◽  
Patrice Brassard ◽  
Benoit J. Arsenault ◽  
Olivier F. Bertrand ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Pressure Response ◽  
Randomized Study ◽  
Pressure Response ◽  
Response To Exercise

scholarly journals Hemodynamic abnormalities during muscle metaboreflex activation in patients with type 2 diabetes mellitus

2019 ◽  
Vol 126 (2) ◽  
pp. 444-453 ◽  
Author(s):  
Silvana Roberto ◽  
Raffaele Milia ◽  
Azzurra Doneddu ◽  
Virginia Pinna ◽  
Girolamo Palazzolo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiac Output ◽  
Systemic Vascular Resistance ◽  
Vascular Resistance ◽  
Blood Pressure Response ◽  
Pressure Response

Metaboreflex is a reflex triggered during exercise or postexercise muscle ischemia (PEMI) by metaboreceptor stimulation. Typical features of metaboreflex are increased cardiac output (CO) and blood pressure. Patients suffering from metabolic syndrome display hemodynamic abnormalities, with an exaggerated systemic vascular resistance (SVR) and reduced CO response during PEMI-induced metaboreflex. Whether patients with type 2 diabetes mellitus (DM2) have similar hemodynamic abnormalities is unknown. Here we contrast the hemodynamic response to PEMI in 14 patients suffering from DM2 (age 62.7 ± 8.3 yr) and in 15 age-matched controls (CTLs). All participants underwent a control exercise recovery reference test and a PEMI test to obtain the metaboreflex response. Central hemodynamics were evaluated by unbiased operator-independent impedance cardiography. Although the blood pressure response to PEMI was not significantly different between the groups, we found that the SVR and CO responses were reversed in patients with DM2 as compared with the CTLs (SVR: 392.5 ± 549.6 and −14.8 ± 258.9 dyn·s−1·cm−5; CO: −0.25 ± 0.63 and 0.46 ± 0.50 l/m, respectively, in DM2 and in CTL groups, respectively; P < 0.05 for both). Of note, stroke volume (SV) increased during PEMI in the CTL group only. Failure to increase SV and CO was the consequence of reduced venous return, impaired cardiac performance, and augmented afterload in patients with DM2. We conclude that patients with DM2 have an exaggerated vasoconstriction in response to metaboreflex activation not accompanied by a concomitant increase in heart performance. Therefore, in these patients, blood pressure response to the metaboreflex relies more on SVR increases rather than on increases in SV and CO. NEW & NOTEWORTHY The main new finding of the present investigation is that subjects with type 2 diabetes mellitus have an exaggerated vasoconstriction in response to metaboreflex activation. In these patients, blood pressure response to the metaboreflex relies more on systemic vascular resistance than on cardiac output increments.

The Blood Pressure Response to Exercise in Youth with Impaired Glucose Tolerance and Type 2 Diabetes

2015 ◽  
Vol 27 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Jane E. Yardley ◽  
Jacqueline Hay ◽  
Freya MacMillan ◽  
Kristy Wittmeier ◽  
Brandy Wicklow ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Pressure Response ◽  
Healthy Weight ◽  
Cross Sectional ◽  
Increased Risk ◽  
Graded Exercise ◽  
Consumption Rates ◽  
Response To Exercise

Type 2 diabetes is associated with hypertension and an increased risk of cardiovascular disease. In adults, blood pressure (BP) responses to exercise are predictive of these complications. To determine if the hemodynamic response to exercise is exaggerated in youth with dysglycemia (DG) compared with normoglycemic overweight/obese (OB) and healthy weight (HW) controls a cross-sectional comparison of BP and heart rate (HR) responses to graded exercise to exhaustion in participants was performed. DG and OB youth were matched for age, BMI z-score, height and sex. Systolic (SBP) and diastolic BP (DBP) were measured every 2 min, and HR was measured every 1 min. SBP was higher in OB and DG compared with HW youth at rest (p > .001). Despite working at lower relative workloads compared with HW, the BP response was elevated during exercise in OB and DG. For similar HR and oxygen consumption rates, BP responses to exercise were slightly higher in OB and DG compared with HW. OB and DG youth both display elevated resting and exercise BP relative to HW peers. Obesity may play a greater role than dysglycemia in the exaggerated BP response to exercise in youth.

scholarly journals Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes

Diabetologia ◽  
2010 ◽  
Vol 53 (7) ◽  
pp. 1295-1303 ◽  
Author(s):  
E. I. Ekinci ◽  
G. Thomas ◽  
R. J. MacIsaac ◽  
C. Johnson ◽  
C. Houlihan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Hypertensive Patients

Exaggerated blood pressure response to exercise in athletes

2012 ◽  
Vol 17 (5) ◽  
pp. 184-192 ◽  
Author(s):  
Julie Turmel ◽  
Valérie Bougault ◽  
Louis-Philippe Boulet ◽  
Paul Poirier
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Response To Exercise

Physiological characteristics and hormonal profile of young normotensive men with exaggerated blood pressure response to exercise

1997 ◽  
Vol 17 (1) ◽  
pp. 1-18 ◽  
Author(s):  
K. Nazar ◽  
H. Kaciuba-Uscilko ◽  
W. Ziemba ◽  
H. Krysztofiak ◽  
E. Wójcik-Ziólkowska ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Physiological Characteristics ◽  
Hormonal Profile ◽  
Response To Exercise

Exaggerated Blood Pressure Response to Exercise – A New Portent of Masked Hypertension

2010 ◽  
Vol 32 (8) ◽  
pp. 560-568 ◽  
Author(s):  
Mehmet Kayrak ◽  
Ahmet Bacaksiz ◽  
Mehmet Akif Vatankulu ◽  
Selim S. Ayhan ◽  
Zeynettin Kaya ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Masked Hypertension ◽  
Response To Exercise
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